⏰ URGENT! ⏰ Into structural modeling, design, integration with experiments, evolution, or platforms? Join our conference, share your work, and see what’s hot! Only 4 days left to submit your abstract! 👇
Join us at #EMBOComp3D to explore cutting-edge breakthroughs in computational structural biology, AI, drug design, and innovative software! 💻
Find out about molecular modelling to systems-level analyses and evolution, and more.
Submit your abstract by 26 Aug ➡️ s.embl.org/csb25-01-bl
One month remaining to register for our conference!
Have a look at the outstanding speakers and programme, and use the link to join the 2nd edition of the Computational Structural Biology Conference in Heidelberg!
Check out HMFF and Mosaic on GitHub: (7/n)
🔗 github.com/KosinskiLab/...
HMFF comes with Mosaic, a software ecosystem for membrane segmentation, refinement, HMFF simulations, and morphometrics. (6/n) 🔗https://github.com/KosinskiLab/mosaic
For example, it allows building models like this filamentous influenza A virion ⬇️ (5/n)
HMFF aids in on-membrane particle picking, supports multiscale modeling, and allows backmapping to atomic detail (4/n)
This enables physically realistic and complete membrane models of cells, organelles, and viruses, consistent with experimental data (3/n)
Helfrich Monte Carlo Flexible Fitting (HMFF) optimizes membrane models directly in electron microscopy densities (2/n)
New method toward modeling cells and viruses! HMFF enables integrative membrane modeling and simulation guided by electron microscopy data. Created by Valentin Maurer and Marc Siggel @embl.org @cssbhamburg.bsky.social, in collaboration with @WPezeshkian lab (1/n) www.biorxiv.org/content/10.1...
Are you a postdoc ready for transition to an independent position? You connect infection biology with cutting-edge structural biology or multimodal imaging? Are you aware of such a colleague?
I am seeking speakers for "The Next Generation in Infection Biology" microsymposium on June 6 2025.
28 children spent the day at CSSB for Girls' and Boys' Day yesterday! The kids built microscopes, conducted chemistry and chromatography experiments, tried VR goggles and much more.
@carobarisch.bsky.social @landaulabcssb.bsky.social @jankosinski.bsky.social @topf-lab.bsky.social
Great work led by our PhD student Iuliia Kotova in collaboration with Fan Liu @fan-liu.bsky.social, Boris Bogdanow, Lars Mühlberg, and Olivier Duss @olivierduss.bsky.social and Guelsah Gabriel labs. Structural analysis by our PhD student Konstantin Gilep.
www.biorxiv.org/content/10.1...
We captured a snapshot of in-cell protein contact sites during influenza A virus infection. In-cell crosslinking, AlphaFold modeling, and functional follow-ups revealed new host factors and mechanisms. A step toward modeling the infected cell.
Sorry Albert, I can't have coffee with you today because time is relative, and mine just ran out. #chatgpt4o
yeah, it went bananas
Draw a ribbon representation of a protein structure shaped like a banana, with alpha-helices, beta-sheets, and loops clearly visible, maintaining realistic molecular geometry and coloring styles typical for protein visualizations.
Join us in Heidelberg for the 2nd edition of #EMBOComp3D! 🧬
Explore cutting-edge AI-driven innovations and classical methods in biomolecular research, new sessions on drug design, and make contacts during the job fair. Submit your abstract by 26 Aug 👉 s.embl.org/csb25-01-bl
⏰ You have until 3 March to submit your abstract and be part of #EESInfection ➡️ https://s.embl.org/ees25-04-bl
🦠 🍄 This symposium will bring together researchers working on different pathogens and pave the way for new strategies to overcome current challenges in the treatment of infections 💡
"We demonstrate that current co-folding approaches largely memorise ligand poses from their training data, hindering their use for de novo drug design."
PDB-IHM (formerly PDB-Dev) is for integrative structures.
Intergrative structures = from multiple experimental & computational methods.
Since mid-2024 assigned PDB ids & DOIs.
Access via wwPDB archive or
PDB-IHM - pdb-ihm.org
👉 https://www.wwpdb.org/news/news?year=2025#677880ea44a8c95814022eb9
The legendary EMBO Integrative Modeling Course is back! If you want to be in this picture in the 2025 edition, just go ahead and register at meetings.embo.org/event/25-bio...
Organized by myself & @amjjbonvin.bsky.social & @arneelof.bsky.social & @lindorfflarsen.bsky.social
"Challenges along the way, but it worked out in the end" youtu.be/HnT1VWzdFWc?...
Perhaps this is not the only time this picture will be shown during a Nobel Prize lecture 😉
Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr
Conclusion for ligand session in #casp16, without a template methods fail
bsky.app/profile/jank...
Does anyone know of published test cases I can use to evaluate the approach? Ideally, the test case would feature a structure published after 30 September 2021, fail with AlphaFold3, and include real crosslinking data.
We still need to see how it generalizes and compares to other tools, but it feels promising, also from looking at results in our running projects!
