Leon-Samuel Icking's Avatar

Leon-Samuel Icking

@lsi

PhD student from the Kalmbach Lab in NeuchΓ’tel flowerpunk 🏡️ + solarpunk β˜€ Anything SynBio (and Plants πŸ‘€)! iGEM Freiburg Ultra🀘 Chaotic neutral

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04.09.2023
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Latest posts by Leon-Samuel Icking @lsi

The science is as over-hyped and borderline fraudulent as the ethics are thorny (and that doesn't even count the George Church, friend of Epstein angle)

05.03.2026 17:53 πŸ‘ 42 πŸ” 14 πŸ’¬ 6 πŸ“Œ 0

Oh no what did BC do...

05.03.2026 18:04 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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🧬 Just pushed new updates to #OpenCloning Assembler based on user feedback!

✍️ Now supports #GoldenBraid and Plant #MoClo

πŸš€ You can edit assembly product names, view a full syntax overview, and enjoy cleaner visuals.

πŸ‘‰ Try it out (link in comments) β€” feedback welcome!

04.03.2026 16:46 πŸ‘ 6 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0
Wave-like contamination on a 1/2 MS plate

Wave-like contamination on a 1/2 MS plate

@contamclub.bsky.social

03.03.2026 08:25 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Since people are liking the Bocchi colors, I have a whole collection of color palettes on my GitHub: github.com/cxli233/Colo...

You will find the hex code, the preview, and the inspiration for each color palette. I hope some of them will be used.

#DataVis

28.02.2026 20:55 πŸ‘ 43 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0
Addgene: OpenPlant Kit Use the OpenPlant toolkit for genetic engineering of the plant synthetic biology model Marchantia polymorpha.

The OpenPlant kit is finally available from Addgene as... a kit :)
www.addgene.org/kits/haselof...
@addgene.bsky.social #marchantia #synbio

26.02.2026 01:08 πŸ‘ 25 πŸ” 10 πŸ’¬ 0 πŸ“Œ 1
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Unmasking Academe’s Gilded Boys’ Club The Epstein files reveal an elite, chummy, and venal scholarly network.

β€œ...the old conferences did not care about diversity. I suggest you not either,” Epstein wrote to Brockman. β€œThe women are all weak, and a distraction sorry.” πŸ˜‘πŸ‘©πŸ»β€πŸ”¬ #AcademicSky

26.02.2026 16:54 πŸ‘ 13 πŸ” 7 πŸ’¬ 2 πŸ“Œ 0

New Ed Yong book in April 2027 let's gooooo

25.02.2026 22:04 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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We teamed up with OpenFlower (@nickdesnoyer.bsky.social), a nonprofit creating designer flowers for art & education, to release 3 limited edition postcards! These flowers were powered by Whole Plasmid Sequencing from Plasmidsaurus.

Want one? Just fill out the form!
tinyurl.com/plasmidsauru...

23.02.2026 16:43 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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πŸš€ Excited to launch the #OpenCloning Assembler!

🧬 Built to demystify Golden Gate for beginners and save time for experts -> MoClo assembly blazing fast ⚑

✍️ Use existing syntaxes or design your own!

#SynBio #GoldenGate #MoClo #OpenSource #Biotech

πŸ‘‰ Try it: app.opencloning.org

Feedback welcome!

20.02.2026 12:54 πŸ‘ 32 πŸ” 14 πŸ’¬ 4 πŸ“Œ 4
Dennis nedry jurrasic park "see nobody cares" meme reads

Hey everybody, this guy still posts on X!

See? Everyone is horrified and disappointed. They feel it speaks directly to your values.

Dennis nedry jurrasic park "see nobody cares" meme reads Hey everybody, this guy still posts on X! See? Everyone is horrified and disappointed. They feel it speaks directly to your values.

18.02.2026 20:13 πŸ‘ 18808 πŸ” 3703 πŸ’¬ 150 πŸ“Œ 30
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The mechanical properties of Arabidopsis thaliana roots adapt dynamically during development and to stress Brillouin microscopy reveals in vivo dynamics of mechanical properties during plant development and response to stress.

Our work now on its final version. We mapped the mechanical properties of roots at tissue and single cell levels using Brillouin microscopy and molecular rotors. Additional mutants and stress measurements from what we previously showed in the preprint are included.
www.science.org/doi/10.1126/...

18.02.2026 20:22 πŸ‘ 58 πŸ” 32 πŸ’¬ 5 πŸ“Œ 3

DeepL seems to have updated and has removed the "thesaurus" feature. Does anybody know a good alternative to DeepL?

19.02.2026 10:19 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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A dual role of Arabidopsis PAL nuclear localization in fine tuning flavonoid biosynthesis PAL’s dual localization links metabolism with transcription, revealing feedback that fine-tunes phenylpropanoid regulation.

Interesting paper: Metabolic enzyme PAL can go into the nucleus in response to high product build up and sequester an activating TF of the pathway, thus acting as a feedback inhibition loop.

From: www.science.org/doi/full/10....
#PlantScience

18.02.2026 13:04 πŸ‘ 17 πŸ” 13 πŸ’¬ 0 πŸ“Œ 0
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Very nice genetic dissection of the roles of BSK kinases in brassinosteroid signaling by Wenqiang Tang's lab. bsk-u (ko for BSK1 1, 2, 3, 4, 5, 6, 7, 8, 10, 11 & 12) really looks like a bri1 null mutant and can be rescued by over-expressing BSK3. nph.onlinelibrary.wiley.com/doi/epdf/10....

17.02.2026 13:42 πŸ‘ 16 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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iGEM Registry The iGEM Registry is a community-curated collection of standardised genetic parts used to design, build and share synthetic biology devices and systems.

Oops, I think this part got all the documentation: registry.igem.org/parts/bba-25.... Or ask Nicole, she'll definetly know

16.02.2026 21:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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iGEM Registry The iGEM Registry is a community-curated collection of standardised genetic parts used to design, build and share synthetic biology devices and systems.

You could try the one the iGEM team made this year (registry.igem.org/parts/bba-25...), should still be in the Signalhaus. to use it it not as an intermedia but rather as primary, you just have to change the epitope I guess πŸ‘

16.02.2026 21:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm!

elifesciences.org/articles/88794

colab.research.google.com/github/Masaa...

15.02.2026 03:04 πŸ‘ 101 πŸ” 34 πŸ’¬ 8 πŸ“Œ 2

Transcription terminators can be strong promoters https://www.biorxiv.org/content/10.64898/2026.02.12.705533v1

14.02.2026 10:21 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Thanks Rita, it's not urgent :)

14.02.2026 12:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The role of pectate lyases in development and stress tolerance in plants - Molecular Biology Reports Pectate lyases (PLs) are a class of pectin-degrading enzymes that catalyze the β-elimination of de-esterified homogalacturonan in a Ca²⁺-dependent manner, releasing unsaturated oligogalacturonides and...

Does anybody have access to this article?
link.springer.com/article/10.1...

14.02.2026 12:08 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
a photo of a fat yellow beetle grub writhing on concrete

a photo of a fat yellow beetle grub writhing on concrete

does anyone know what kind of beetle this is? inaturalist is just suggesting some kind of scarab. I saw it in the adirondacks by tupper lake in july

13.02.2026 16:05 πŸ‘ 19 πŸ” 5 πŸ’¬ 16 πŸ“Œ 0
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A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Why hasn't this paper gotten more attention?

13.02.2026 01:40 πŸ‘ 34 πŸ” 15 πŸ’¬ 5 πŸ“Œ 1

πŸ”΅mTurquoise2-based glucose biosensors TINGL and THINGL from @joachimgoedhart.bsky.social and the Teusink Lab!
Find the plasmids here: www.addgene.org/browse/artic...

12.02.2026 21:03 πŸ‘ 20 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0
University of Freiburg

PhD opening
Join a collaborative, interdisciplinary project the Excellence Cluster Future Forests @uni-freiburg.de, working on CRISPR/Cas in poplar to understand how trees cope with climate stress.
Apply here: uni-freiburg.de/en/job/00004...
@dompsfr.bsky.social @biologyunifreiburg.bsky.social

11.02.2026 09:57 πŸ‘ 26 πŸ” 32 πŸ’¬ 0 πŸ“Œ 2

We're recruiting a PhD student to try and understand stress memory and gene function, using gene editing, in trees! #plantscience

11.02.2026 10:02 πŸ‘ 12 πŸ” 13 πŸ’¬ 0 πŸ“Œ 1
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Exclusive | OpenAI Executive Who Opposed β€˜Adult Mode’ Fired for Sexual Discrimination Ryan Beiermeister, who served as the vice president leading OpenAI’s product policy team, had raised concerns about the upcoming launch of erotic content.

OpenAI fired a VP who opposed their erotica rollout (and had started a company-wide peer mentorship program for women), allegedly telling her it was because she discriminated against a man πŸ€” www.wsj.com/tech/ai/open...

11.02.2026 12:03 πŸ‘ 799 πŸ” 301 πŸ’¬ 15 πŸ“Œ 47

Why do some scientists say "Bluesky is dead. I have no engagement. I have more engagement on X"? My TL is full of cool science, queer art, weird history facts, politics and whimsy. You're just not doing it right, man. Plus the fascism

10.02.2026 20:10 πŸ‘ 145 πŸ” 10 πŸ’¬ 14 πŸ“Œ 2

Anyone ever tried super glue (cyanoacrylate) for mounting coverslips with stained mammalian cells, to be used for fluorescence microscopy?
I'm looking for ways to conserve microscopy samples for a looooooong time...

07.02.2026 19:40 πŸ‘ 17 πŸ” 10 πŸ’¬ 8 πŸ“Œ 3