TaylorLab-Chembio

Cation–Cation Photosensitization for Protein Ligation and Intracellular Catalysis We report here a photosensitized strategy for protein labeling in which N-substituted pyridinium salts are activated using a 2,4-diaryl-N-methyl quinolinium scaffold. Structure–reactivity relationship...

Check out the final version of our work on photocatalytic protein ligation in @jacs.acspublications.org. Using a matched pair of simple aromatic cations, we show rapid labelling at the peptide, protein, and intracellular level. Great work by Vishal, Hieu, and Sam!

pubs.acs.org/doi/abs/10.1...

Check out our latest preprint in @biorxivpreprint.bsky.social. Like charges usually repel each other, but here we show the right pair of aromatic cations can actually be sensitize each other for protein labelling, even inside a cell. Congrats to Vishal Hieu and Sam!
www.biorxiv.org/content/10.1...

Facile Trifluoromethylation of Arenes and Heterocycles via a Bench Stable Photocaged Trifluoromethylation Reagent Herein we report a simple radical aromatic trifluoromethylation process that utilizes a cationic, aromatic sulfonate ester as a trifluoromethyl radical photocage. This chemistry allows for the rapid a...

Check out our 2nd preprint of the week! It was a privilege to collaborate with @gustafsonlabsbu.bsky.social to demonstrate that our recently developed radical photocages enable quick and simple photo-induced trifluoromethylation of small molecule organics and API's.

chemrxiv.org/engage/chemr...

Check out our latests work in collaboration with @taylorlab-chembio.bsky.social! We evaluated their biomolecular photocaged trifluormethylation reagent on small molecules, finding it effected rapid trifluoromethylation of diverse aromatics, including several APIs.
chemrxiv.org/engage/chemr...

A pleasure collaborating with you Jeff!

Designer Aromatic Cations for Photo-Induced Protein Ligation, Imaging, and Intracellular Labelling at Extended Wavelengths Photo-induced protein labelling strategies have become essential tools in chemical biology, but most strategies require high energy wavelengths of light as input to drive reactivity. Recently, we repo...

Happy to share our preprint in @biorxivpreprint.bsky.social on designed aromatic cations for photochemical protein ligation. We show intracellular labelling w/ green light, wash-free imaging, and mechanistic insights. Congrats to Pranab, Pooja, Sanwaye, and Vishal! www.biorxiv.org/content/10.1...

Hey Organic Asst Profs coming up for tenure (and your senior colleagues) — it is nomination season for the ACS DOC Young Academic Investigators Symposium. Deadline is Feb. 6, 2025. The website has last year’s date 😳 but the other info is right. #ChemSky www.organicdivision.org/meetingsuppo...

Traceless Chemoenzymatic Peptide Synthesis at University of Nottingham on FindAPhD.com PhD Project - Traceless Chemoenzymatic Peptide Synthesis at University of Nottingham, listed on FindAPhD.com

I have an AstraZeneca-funded PhD position available (4 years), based in my lab (School of Chemistry, University of Nottingham); start date Oct 2025!

Traceless Chemoenzymatic Peptide Synthesis

Application deadline: 6 Jan 2025. Get in touch!!!

www.findaphd.com/phds/project...

Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7

Nice work Ross and colleagues!

A Pyridinium Ylide-Alkylation Strategy for the Structural Diversification of N-Carbamoylpyridinium Salts A pyridinium ylide-alkylation strategy has been developed for selectively accessing N,N-disubstituted pyridinium salts from monosubstituted pyridinium salts possessing ambident nucleophiles. The metho...

Here's the link to the paper! pubs.acs.org/doi/10.1021/...

Thanks for bringing together the #chembio community on bluesky by creating this list! If you create a 2nd one, would love to be added to it!

📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.

Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj

Let's make ChemBioSky even greater again!

#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

What better way to open our acct on bsky than by announcing a new paper! Check out the final version of our pyridinium-ylide alkylation approach for accessing highly bespoke #chembio pyridinium probes in JOC/@amerchemsociety.bsky.social! Congrats to authors Ash and Ben on the great work!