Hubert Salvail

Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH | mSphere To cause disease, pathogens must express their virulence genes at the right time and in proper levels. Here, we establish that a small RNA (sRNA) restricts the activation of a regulator critical for t...

Check out our new article! Congrats to Michelle Prophete, Alex Mabel and Payton Bowman for their great work!

Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH | mSphere journals.asm.org/doi/10.1128/...

From lab reagent to metabolite: the riboswitch ligand guanidine as a relevant compound in bacterial physiology | Journal of Bacteriology More than two decades ago, the first naturally occurring mRNA elements regulating gene expression by directly binding target ligands, termed riboswitches, were discovered in bacteria (1–4). Since then, more than 55 classes of riboswitches have been characterized (5, 6), advancing our general knowledge of gene regulation and stress response, but also unveiling unexpected biological roles for compounds whose relevance had remained elusive. A notable example is the discovery of riboswitches recognizing c-di-AMP and c-AMP-GMP (7, 8), which hinted at important biological functions for the two molecules that were later revealed to act as second messengers in key cellular processes such as biofilm formation, chemotaxis, sporulation, and virulence (9–11).

Check out our new review on guanidine biology! Stay tuned for more exciting findings on guanidine from our group.

From lab reagent to metabolite: the riboswitch ligand guanidine as a relevant compound in bacterial physiology | Journal of Bacteriology journals.asm.org/doi/10.1128/...

I’m excited to share some of the results of my postdoctoral work @yalemicropath.bsky.social, where we reveal how a mechanism of nutritional immunity deployed by macrophages against Salmonella governs their metabolic behavior inside host cells, just published @pnas.org: www.pnas.org/doi/10.1073/...

Reposting for the new year: register for the Mechanisms of Microbial Transcription GRC and GRS!

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo Solar UVB light causes damage to the outermost layer of skin. This insult induces rapid local responses, such as dermal inflammation, keratinocyte cel…

sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...

Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature Microbiology Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

Enjoying this deep dive into the link between coffee and the microbiome

They found a microbe (Lawsonibacter asaccharolyticus) that is 4- to 8-fold more abundant in coffee drinkers, and correlates with coffee intake in worldwide populations

www.nature.com/articles/s41...

The Department of Medical Microbiology and Immunology at the University of California Davis, School of Medicine, invites applications for a full-time faculty position in Microbiome Sciences. Apply by December 11th at:

recruit.ucdavis.edu/JPF06847

Thank you!

Hi! Could you please add me to the list? Thanks much!

Starter pack to help the #MicrobialRNA community find each other!

#RNAsky #Microsky

The list is from complete right now: I made it quickly and I expect more folks will be coming over to the sky…

So please comment or message me if you’d like to add yourself or others! 🙌 🧬 🦠

go.bsky.app/Nmh86cu

Repost for all the new #MicroSky friends that arrived in the last few days. We are super excited and hope to see many of you in Spain next year 😍. Thanks for reposting 🔁