The first image is the broken experiment, the second image is the disordered prediction from AlphaFold. It's disordered, so we have flexibility with what we do with the tails
I'll probably just run a little coarse-grained simulation when you get close.. they'll be a flailing blur.
WIP: Trying to do something more interesting with the disordered regions of synaptophysin (green) in the syp-vamp2 complex of this synaptic vesicle. I have this bug at the moment, a little nightmarish, but cool looking. Flailing tentacles...
The synaptophysin disordered regions have misleading C6 symmetry from the AlphaFold prediction, so I'll do something with those too.
Almost there. I need to double check principal axes and offsets, tweak some things, add a membrane.
For the VAMP2 cytoplasmic SNARE domains I did some randomized rigid body transforms, and took a bit of license to spread out the dangly bits (disorganized regions from the AlphaFold prediction).
WIP: modelled the synaptophysin-VAMP2 complex for our synaptic vesicle. This complex is involved in vesicle fusion.
SYP forms a hexamer with 12 copies of VAMP2, a key part of the fusion machinery.
No membrane. Need VAMP complex, etc. Principal axis for many proteins isn't set yet, nor transmembrane offset.
Glutamate charging works like this: The ATPase uses ATP to create a proton gradient, and VGluT uses the gradient to exchange glutamate (from outside) with protons (from inside). It's really quite cool how they work together.
Lazy morning building a synaptic vesicle from scratch. Super WIP and not correct. Much to do.
But it has the coolest guys imho:
- Amber: Vesicular glutamate transporter (VGluT)
- Red: V-ATPase
No membrane. Need VAMP complex, etc.
#screenshotsunday
I don't know anything about CloudXR.. I wonder if it can be hosted/implemented locally, or is tied to NVIDIA's cloud?
Still reading the API.. and digging into it. CloudXR, OpenXR. Looks like perhaps "gaze regions" are sent to the server (not exact gaze rays)..
Very interesting. Hoping gaze regions come to CompositorServices.
HIV model:
Johnson et al. (2014) pubs.rsc.org/en/content/a...
WIP: Updated CellWalk's editor for macOS. I love how liquid glass adapts to the scene's colour palette.
We're looking at an HIV model the folks at Scripps Research
(this is just our dev tool)
@dreamwieber.bsky.social just released a beautiful video exploring my app CellWalk on the M5 Apple Vision Pro. Totally made my day. Thanks for the support Gregory! :)
I don't have an M5, so I was conservative with the parameters I just shipped. We can push it way up once I have one. Please share your experience and I'll vicariously 😁
I just updated CellWalk for the M5 Apple Vision Pro! This app really pushes the GPU (entire cells with billions of atoms) and it's a great way to test the M5.
CellWalk on M5 increases resolution and detail 1.5x over M2! Huge. It's super sharp and detailed. Apple Intelligence is also way faster.
I quietly released new features for Apple Vision Pro in the last update: Widgets and on-device AI explanations powered by Apple Intelligence.
I don't have an M5 yet, has anyone tried CellWalk on the M5 Apple Vision Pro?! How is it? more resolution (it should get more by default)?!
The clips feature the incredible scientific work of @martinamaritan.bsky.social and @ludovicautin.bsky.social et al.
www.sciencedirect.com/science/arti...
Oh! and a Liquid Glass redesign:
Concept chains: Tap and dive deep into unfamiliar terms and concepts. It's pretty cool.. because now everything in the app is interactive, from the visuals to the text itself.
CellWalk is featured in Apple's new article on Apple Intelligence and Foundation Models.
It's a really fun new way to learn about concepts and terms in the app, and I really enjoyed building it.
Concept chains: Tap and dive deep into unfamiliar terms and concepts. It's pretty cool.. because now everything in the app is interactive, from the visuals to the text itself.
Getting ready for my talk tomorrow on "Thoughtful Spatial Design" at KWDC25 tomorrow!
Hanging out at Fritz Coffee in Gangnam, Seoul. I love this location, nostalgic vibe.
🦠 NEW VIDEO 🦠
The molecular biology of how Mycobacterium Tuberculosis evades the immune system so well.
Starting with this simulation of a full outer envelope of m.TB--let's explore how the deadliest & most persistent human pathogen completely hacks our immune response. #molecularbiology
This is brilliant, thanks for sharing. It does everything, sound, fun and interactive tools. Long "hmmmmm" and chin scratching
"Synaptic gap" by L. Alves da Silva, K. Ozvoldik, & E. Krieger / YASARA Biosciences. Sourced from PetWorld. License CC BY-SA 4.0.
The video and app display two incredible models:
"Model of the presynaptic bouton" by B. Rammner, K. Ozvoldik, & E. Krieger / YASARA Biosciences. Sourced from PetWorld. License CC BY-SA 4.0.
Check it out! The @ucalgary.bsky.social
where I did my PhD just published an article about my app,
@cellwalk.bsky.social
being a Finalist in the 2025 Apple Design Awards. Super cool.
www.ucalgary.ca/news/ucalgar...
#wwdc25
