I want to thank my co-authors Hélène Eltchaninoff, Elaine Tseng & Vinod Thourani, who argue pros and cons for this interesting vignette in our latest #NEJM Clinical Decisions. Read the full discussion below and cast your vote. @nejm.org @ai.nejm.org
#GLP1s have transformed #obesity care, but can they compete with surgery? #AMichaelLincoff & #ScottShikora argue the pros and cons of #semaglutide vs #bariatricsurgery for a man with obesity in our @nejm.org Clinical Decisions www.nejm.org/doi/full/10....
Congratulations to Dr Christos Kotanidis who has been awarded the 2025 ESC Young Investigator Award in Preventative Cardiology at the European Society of Cardiology Congress in Madrid.
Read more 👇
shorturl.at/KU2Be
#ZakKohane on #AI in #PeerReview: the surge in scientific publication is straining the conventional review system beyond capacity. @ai.nejm.org piloting AI-augmented fast track review: manuscripts w high prior of being good gets assigned to #GPT5 + a human, disposition reviewed by editorial team!
Our comparisons of submitted and published abstracts suggest that peer review and editorial processes result in substantial revision of research reports. The findings reinforce the importance of editorial oversight in scientific publishing, highlighting its role in refining study design communication, reporting of outcomes, and overall clarity in research dissemination.
Comparing submitted vs published RCT abstracts eval'd at @nejm.org in 4 domains (design, outcome, AEs, conclusions). published abstracts improved in a mean 0.9 domains. More improvements observed in leading gen med vs 433 other journals (72 % vs 48%) www.acpjournals.org/...
@cpkotanidis.bsky.social
Well done @cpkotanidis.bsky.social ! Also check out our manuscript in @annalsofim.bsky.social url.us.m.mimecastprotect.com/s/kNYpCDkAO2...
Excited to present our work tomorrow on a novel #AI #metabolomics score to predict #cardiovascular risk in #psoriasis at the #ESCCongress #WCCardio 2025 Young Investigator Award session in Preventive Cardiology. #PreventiveCardiology #CardioRheumatology #YIA
Four Original Articles were simultaneously published in NEJM and presented earlier today at this year’s #ESCCongress in Spain.
@escardio.bsky.social
The #1 cause of death in women is heart disease. A new report makes the case for treating women with statins who have a high inflammation marker (hs-CRP) but no traditional risk factors academic.oup.com/eurheartj/ad...
🎥 Snackable Science from #ESCCongress 2025 in Madrid!
Roxana Mehran & Michael Gibson break down the new Focus Update of the 2019 #ESCGuidelines on #dyslipidaemias with the latest recommendations you need to know 👇
Clinical Decisions Managing Obesity Christos P. Kotanidis, M.D., D.Phil., A. Michael Lincoff, M.D., and Scott A. Shikora, M.D. An illustration of the man walking his dog
For a man with #obesity, would you recommend the initiation of semaglutide therapy or bariatric and metabolic surgery? Read the case vignette and essays on both treatment options and cast your vote: nej.md/3HiAnJz
#MedSky #EndoSky
The win ratio method is gaining traction in #RCTs. Is it just a trend or a smarter way to look at composite hierarchical outcomes? We break it down in our latest Stats, STAT!📊 in NEJM Evidence. youtube.com/watch?v=jKtF... #stats @nejm.org @sarahgorey.bsky.social @chardin.bsky.social @ai.nejm.org
1/ 🚨 NEW #BeyondJournalClub w/ @nejm.org: REDUCE-AMI
What is the long term benefit of beta blockers in patients with preserved EF following an MI?
🖥️: www.coreimpodcast.com/2025/06/25/b...
Early Invasive or Conservative Strategies for Older Patients With Acute Coronary Syndromes
In older patients with acute coronary syndrome, an early invasive strategy did not reduce all-cause mortality but decreased recurrent myocardial infarction and repeated revascularization. https://ja.ma/40hDK9G
What is it like to be an NEJM editorial fellow for a year? This year’s fellows discuss what they have learned, how their experience will help their career, and what surprised them. Apply for the 2026–27 NEJM editorial fellowship by August 1. Learn more: nej.md/3cCQajB
#MedSky #MedEd
60-Second Journal Club: The SUMMIT trial examined cardiovascular outcomes of treatment with tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Read the full trial results: nej.md/4hRGaTY
#MedSky #CardioSky @cpkotanidis.bsky.social
Aspiration Thrombectomy for Coronary Stent Thrombosis Panel A: Coronary angiography revealing a large thrombus in the LAD artery stent. Panel B: The thrombus that was removed with the use of an aspiration catheter. Panel C: The stent that was dilated with a balloon at high pressure, which resulted in improved flow.
A 73-year-old woman presented with severe chest pain. She had undergone multivessel percutaneous coronary intervention 2.5 years earlier. Angiography revealed a large thrombus in an LAD artery stent (shown in videos). Read the full case details: nej.md/4jC2aSa
#MedSky #CardioSky
Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏
New research alert: Our latest report highlights a significant reduction in coronary #inflammation and residual inflammatory risk as captured by #CCTA imaging using CaRi-Heart AI in women with #BreastCancer 2 years post-RT
#AI #CardioOncology #CardioEd #EHJ
@escardio.bsky.social
Presented at #ACC25:
In the PROTECT-TAVI trial, the routine use of cerebral embolic protection during TAVI did not reduce the incidence of stroke within 72 hours or before discharge from the hospital (if discharge occurred sooner). Full trial results: nej.md/41RONXi
@accintouch.bsky.social
Ever wondered how interim analyses work in #RCTs? 📊 Check out our Stats, STAT! video at NEJM Evidence: @nejm.org @ai.nejm.org @sarahgorey.bsky.social evidence.nejm.org/doi/full/10.... #MedStats #ClinicalTrials
Tirzepatide was previously shown to provide sustained weight reductions in adults with #obesity. Longer-term findings in adults with both obesity and prediabetes are summarized in a new Quick Take video. youtu.be/c9uazgSdDJc
#MedSky #EndoSky
🫀New research🫀 Across 6 #RCTs (n=2,257) early invasive management in #female patients with #NSTEACS did not reduce all-cause mortality or MI risk at 6 months vs. delayed management. #AHAJournals @drroxmehran.bsky.social @vijaykunadian.bsky.social
www.ahajournals.org/doi/10.1161/...
In the HELIOS-B trial, researchers assessed the efficacy and safety of vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy. NEJM Editorial Fellow Christos Kotanidis, MD, DPhil, summarizes the results. Full trial: nej.md/3X5nl5Q
#MedSky #CardioSky @cpkotanidis.bsky.social
EDITORIAL “What can we do to counter the current chaos? At the least, we can try to maintain order. In our roles as editors, this means continuing to do what we think makes a difference: publishing the highest-quality research, analysis, opinion, and educational content that can improve patient health.” “Order out of Chaos” by NEJM Editor-in-Chief Eric J. Rubin, M.D., Ph.D.
In a new editorial, NEJM Editor-in-Chief Eric J. Rubin, MD, PhD, comments on the effects of the raft of executive orders from the current administration on scientific research and public health. Read the full editorial: nej.md/4gXeRFW
#MedSky
🤔Recurrent severe abdominal pain with no clear cause? In the latest #NEJMDoubleTake we unpack a perplexing case with a broad differential, key clinical clues, and a surprising diagnosis. 🎥🩺 🏥🔬 nejm.org/doi/full/10.... @nejm.org
