GEARs

Please join us on November 20th! We are very grateful for our first sponsorship - Molecular Instrument!

ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program Mutations in the chromatin reader and tumor suppressor ZMYND11 are the cause of ZMYND11-related syndromic intellectual disability (ZRSID), a disorder characterized by symptoms such as language and mot...

Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...

Much appreciate the spotlight on our (‪@adelmanlab.bsky.social‬) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology

Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!

You can register at: us06web.zoom.us/webinar/regi...

Farnung Lab

Outstanding work from Allison James who will graduate next month! If you like our work, consider applying to the Farnung Lab. More info: farnunglab.com


🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...

Excited to see everyone tonight at Whitehead Institute for the 2nd GEARS seminar, featuring three talks from Harleen Saini, Vikram Agarwal, and Ava Carter!

Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation A major challenge in human evolutionary biology is to pinpoint genetic differences that underlie human-specific traits, such as increased neuron number and differences in cognitive behaviors. We used ...

What contributes to human specific neural specification? Check out these two wonderful preprints from a wonderful scientist Ava carter! 1. www.biorxiv.org/content/10.1...; 2. www.biorxiv.org/content/10.1...

Stay tuned! third preprint is on its way!

🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...

🎆Next #FragileNucleosome meeting is less than a week away! We are delighted to host @manucazottes.bsky.social, @robertadolling1.bsky.social & @leandrosboukas.bsky.social ! We will discuss evolution of XIST regulatory network, cancer epigenetics, and MDEMs!
🗓️ us06web.zoom.us/webinar/regi...

After a long break, GEARs is back! We will feature three speakers on Feb 27th, 6PM in Goldenson 122. Please register via docs.google.com/forms/d/e/1F... so we can get enough food and drinks. You can nominate speaker sor volunteer for our future seminars through docs.google.com/forms/d/e/1F....