Cermav - UPR 5301 (@cermav)

"Antiadhesive glycoconjugate metal complexes targeting pathogens Pseudomonas aeruginosa and Candida albicans"

Open access 💪 hal.science/hal-05145635v1

@cnrs.fr
@glyco-alps.bsky.social
@labexarcane.bsky.social

05.03.2026 09:24 👍 0 🔁 0 💬 0 📌 0

Antiadhesive glycoconjugate metal complexes targeting pathogens Pseudomonas aeruginosa and Candida albicans Glycoconjugate metal complexes target bacterial and fungal proteins for antiadhesive effects.

New publication from @anneimb.bsky.social, E. Gillon, and collaborators from School of Biological and Chemical Sciences, Trinity College, Technological University, Maynooth Univ. & Univ. of Manchester.

05.03.2026 09:24 👍 0 🔁 0 💬 0 📌 1

Lectins in the sweet strategy of lung pathogens: from structural glycobiology to design of glycomimetic pathoblockers Glycan epitopes exposed on the host cell surface serve as receptors for a wide range of proteins expressed by microorganisms. Among these, lectins that are produced by viruses, bacteria, and fungi in either soluble or surface-attached forms, play key roles in infection processes. The fine specificity that many of these glycan-binding proteins display toward human glycan epitopes is the result of long-term co-evolution. Structural insights into lectin architecture, their binding sites, and the atomic details of their interactions with glycans are crucial for designing antimicrobial agents capable of competing with infectious processes and potentially supplementing antibiotics in the current fight against antimicrobial resistance. This review highlights how structural lectinology can serve as a starting point for fruitful collaborations with synthetic carbohydrate chemists in the design, synthesis, and characterization of glycomimetics acting as pathoblockers. Various strategies have been developed to target lectins, exemplified here by soluble lectins from the lung pathogens Pseudomonas aeruginosa and members of the Burkholderia cepacia complex. The affinity for monosaccharide ligands has been enhanced through heterocyclic functionalization using classical medicinal chemistry approaches, with the best results obtained by mimicking natural glycan receptors. Alternatively, the oligomeric nature of lectins allows the design of divalent or multivalent ligands, which exhibit much stronger affinity due to the cluster effect. Covalent inhibitors and non-carbohydrate glycomimetics also represent promising leads for future strategies to combat antimicrobial resistance.

New review from @anneimb.bsky.social

"Lectins in the sweet strategy of lung pathogens: from structural glycobiology to design of glycomimetic pathoblockers"

Open access 👍 hal.science/hal-05388018v1

@cnrs.fr
@glyco-alps.bsky.social
@labexarcane.bsky.social

05.03.2026 09:21 👍 0 🔁 0 💬 0 📌 0

@cnrs.fr
@agencerecherche.bsky.social
@labexarcane.bsky.social

05.03.2026 09:19 👍 0 🔁 0 💬 0 📌 0

The Parkinson's disease drug Tolcapone and analogues are potent glycomimetic lectin inhibitor of Pseudomonas aeruginosa LecA The notorious pathogen Pseudomonas aeruginosa relies on the lectin LecA for host cell adhesion, invasion, and biofilm formation. Motivated by the pressing need for new antiinfective therapies caused by antimicrobial resistance, inhibitors of LecA are under investigation. Complementary to the use of carbohydrate-based inhibitors, we have previously identified catechols as weak but specific ligands of LecA, constituting a novel class of noncarbohydrate glycomimetics. Here, we present the catechol Tolcapone and derivatives as a new class of potent glycomimetics. By growing the initial millimolar fragment hits, we identified Tolcapone as a promising compound. To gain insight into the structure-activity relationship (SAR) of catechols as LecA binders more than 3,200 compounds of the Roche in-house library were experimentally screened in a competitive binding assay at three concentrations. Of these, 48 compounds were chosen for further investigation, resulting in compounds equipotent to aryl galactosides, the current epithome of LecA inhibition. X-ray crystallography and saturation transfer difference NMR spectroscopy revealed conserved interactions of the catechol moiety in the glycan binding site of LecA and rationalized the observed SAR. Our findings demonstrate that it is possible to develop potent non-carbohydrate glycomimetic lectin inhibitors, paving the way for a new avenue of research that could yield innovative antiinfective drugs.

New publication from A. Varrot and collaborators from HIPS, UKS, DZIF, Mahidol University and Roche Pharma :

"The Parkinson's disease drug Tolcapone and analogues are potent glycomimetic lectin inhibitor of Pseudomonas aeruginosa LecA"

Open access 👍 hal.science/hal-05345236

05.03.2026 09:19 👍 0 🔁 0 💬 0 📌 1

@cnrs.fr
@labexarcane.bsky.social

05.03.2026 09:16 👍 0 🔁 0 💬 0 📌 0

Glycosynthase-Based Synthesis of Peptidoglycan Oligosaccharides to Address Bacterial Cell-Wall Elongation Processes Most antibiotics used in human medicine inhibit the biosynthesis of peptidoglycan (PG), a vital component of the bacterial cell wall. However, the rapid rise in antimicrobial resistance (AMR) represents a major global health threat. Gaining deeper insight into PG metabolism is a crucial step in combating AMR, an objective achievable only through the use of welldefined molecular probes. In this study, we developed a chemo-enzymatic method to synthesize PG oligosaccharides using a lysozyme-derived glycosynthase. To prevent unwanted polymerization and enable precise control over product size, a glycosyl fluoride donor bearing a terminal galactosyl unit was designed. The trisaccharide Gal-beta-(1→4)-GlcNAc-beta-(1→4)-1,6-anhydro-MurNAc was biosynthesized in metabolically engineered Escherichia coli cells and subsequently fluorinated at the reducing end via chemical modification. Successive glycosylation and degalactosylation steps using this donor, starting from two disaccharide acceptors, led to the synthesis of PG tetra-, hexa-, and octasaccharides, with 60-70% yield at each cycle. These compounds were used to probe the specificity of E. coli DedD, a SPOR-domain-containing protein involved in bacterial cell division. NMR spectroscopy and NMR-restraint-driven molecular dynamics provide new insights into the role of this protein relative to other E. coli SPOR domain-containing proteins.

New publication from S. Fort, S. Cottaz, E. Richard-Millot, S. Pradeau, S. Armand and collaborators from Institut de Biologie Structurale :

Glycosynthase-Based Synthesis of Peptidoglycan Oligosaccharides to Address Bacterial Cell-Wall Elongation Processes

Open access 👍 hal.science/hal-05527575

05.03.2026 09:15 👍 0 🔁 0 💬 0 📌 1

Right-Handed Chiral Photonic Cellulose Nanocrystal Films Chirality transfer across length scales is a fascinating phenomenon that has intrigued researchers across disciplines. This is especially the case with cellulose, where, despite being one of the most exploited materials in our society, such as paper and cotton, it remains elusive when it comes to the transfer of the intrinsic chirality at the molecular scale to larger hierarchical structures. Here we show that in the case of cellulose nanocrystals (CNCs), allomorphic transformation from cellulose I to cellulose II can lead to chirality inversions in chiral nematic suspensions. This phenomenon allows the fabrication of right-handed chiral photonic films using CNCs extracted from standard plant biomass, which is first mercerized and then subjected to sulfuric acid hydrolysis followed by desulfation. Similar to standard cellulose I-based CNC self-assembly, the twist chirality and aspect ratio of the left-handed CNCs in cellulose II can be significantly modified through crystallite aggregation engineering. In contrast to molecular liquid crystals, chirality inversion has never been presented in colloidal liquid crystals, and our findings present a step towards the development of so far inaccessible cellulose materials beyond the native crystallinity

New publication from Y. Nishiyama and Y. Ogawa + collaborators from Jilin Univ. Beijing Institute of Technology and Max Planck Institute of Colloids and Interfaces :

"Right-Handed Chiral Photonic Cellulose Nanocrystal Films"

Open access hal.science/hal-05522715v1

@cnrs.fr

05.03.2026 09:13 👍 0 🔁 0 💬 0 📌 0

@cnrs.fr
@glyco-alps.bsky.social

03.03.2026 10:37 👍 0 🔁 0 💬 0 📌 0

Cyclodextrin-Supported Passerini Three-Component Reaction as a Synthetic Platform for Homogeneous Modification of Carboxymethylcellulose in Aqueous Media The prime objective of this study was to construct a synthetic platform for an aqueous reaction system that enabled chemical modification of environmentally-friendly resources by using multicomponent reactions (MCRs). The target system was based on the Passerini three-component (P-3CR) reaction among carboxymethylcellulose (CMC), formaldehyde (F-CHO), and 1-adamantyl isocyanide (Adm-NC), which has been a heterogeneous reaction due to the insolubility of Adm-NC in water. Such a reaction to produce gel-like products is difficult to control. In this study, we have added cyclodextrins (CDs) to the system in order to bypass uncontrolled interactions between the Adm-NC and water molecules by utilizing a host-guest complexation between the CDs and adamantane (Adm) derivatives. The CD-supported P-3CR homogeneously proceeded in water. The resulting products have been characterized to clarify the impact of the CDs and stoichiometric ratios of the three starting materials in the feeds. This paper includes another minor topic that CDs have been subsequently released by dialysis by using an automatic continuous ultrafiltration apparatus, making the inherent Adm units exposed in aqueous media. The CD-released P-3CR products showed selforganization properties due to hydrophobic associations between the exposed Adm units.

New publication from J-L. Putaux and coll. from Yamagata Univ. & Nagoya Univ. :

"Cyclodextrin-Supported Passerini Three-Component Reaction as a Synthetic Platform for Homogeneous Modification of Carboxymethylcellulose in Aqueous Media"

Open access 👏
hal.science/hal-05263316

03.03.2026 10:37 👍 0 🔁 0 💬 0 📌 1

New publication from R. Borsali and coll. from National Taiwan Univ. :

"Oligosaccharide Block Copolymers with Branched Architectures and Channel Energy Level Optimizations for High-Performance Floating Gate Phototransistor Memory"

Open access 💪https://hal.science/hal-05377977v1

@cnrs.fr

03.03.2026 10:34 👍 1 🔁 0 💬 0 📌 0

New publication from J-L/Putaux and collaborators from LaMaCop, IMMM and SME :

"Harnessing chitin nanocrystals and PEDOT nanocomposites: Toward eco-friendly conductive materials for supercapacitor applications"

Open access 👍https://cnrs.hal.science/hal-05232337/

@cnrs.fr

03.03.2026 10:31 👍 0 🔁 0 💬 0 📌 0

Microalgae, sunlight, and starch: low cell concentration is optimal for outdoor production under nutrient stress Submitted on : Monday, January 5, 2026-8:32:10 PM

New publication from J-L. Putaux & C. Lancelon-Pin, and collaborators from @cea.fr & Aix Marseille Université :

"Microalgae, sunlight, and starch: low cell concentration is optimal for outdoor production under nutrient stress"

Open access👌 ➡️ hal.science/hal-05442643/

@cnrs.fr

27.02.2026 08:46 👍 0 🔁 0 💬 0 📌 0

@cnrs.fr
@agencerecherche.bsky.social / the GAGs- NanoSensor project (ANR-21-CE11-0011).

27.02.2026 08:42 👍 0 🔁 0 💬 0 📌 0

Structurally defined synthetic heparin oligosaccharides reveal unique signatures for nanopore structural analysis of GAGs Efforts to fully understand the structure-to-function relationships of glycosaminoglycans (GAGs) have been hampered by the complexity and polydispersi…

New publication from E. Richard-Millot & B. Priem, and coll. from Univ. Paris-Saclay, Univ. Evry, CY Cergy Paris Univ.:

Structurally defined synthetic heparin oligosaccharides reveal unique signatures for nanopore structural analysis of GAGs

www.sciencedirect.com/science/arti...

27.02.2026 08:41 👍 0 🔁 0 💬 0 📌 1

Avalaible in open access👍

cnrs.hal.science/hal-05371837

27.02.2026 08:38 👍 0 🔁 0 💬 0 📌 0

Phosphorylated lignin–cellulose nanofibrils for multifunctional PVA composites with UV-absorption and flame-retardancy Composite manufacturing often requires multiple additives to achieve desired properties in terms of strength, safety, and durability. Here, we produce…

New publication from J-L. Putaux and coll. from
Mohammed VI Polytechnic University & University of Sfax !

"Phosphorylated lignin–cellulose nanofibrils for multifunctional PVA composites with UV-absorption and flame-retardancy"

www.sciencedirect.com/science/arti...

@cnrs.fr

27.02.2026 08:37 👍 0 🔁 0 💬 0 📌 1

Self-assembly of dextran-solanesol block copolymers into spherical micelles for photostabilization of quercetin Compared with cyclodextrins (CD), carbohydrate-based block copolymers offer enhanced tunability regarding guest encapsulation properties by forming mi…

New publication from R. Borsali and coll. from Ghent Univ.,Hokkaido Univ., National Taiwan Univ., Kanazawa Univ. & National Central Univ. !

"Self-assembly of dextran-solanesol block copolymers into spherical micelles for photostabilization of quercetin"

www.sciencedirect.com/science/arti...

27.02.2026 08:35 👍 0 🔁 0 💬 0 📌 0

Microphase separation in maltooligosaccharide-based block co-oligomers with dominant sugar volume fractions: Toward a comprehensive understanding of the phase behavior Block co-oligomers (BCOs) consisting of oligosaccharides and hydrophobic terpenoid blocks exhibit microphase-separated structures of various morpholog…

New publication from R. Borsali & coll. from Hokkaido Univ. & National Tsing Hua Univ. :

"Microphase separation in maltooligosaccharide-based block co-oligomers with dominant sugar volume fractions: Toward a comprehensive understanding of the phase behavior"

www.sciencedirect.com/science/arti...

26.02.2026 10:26 👍 0 🔁 0 💬 0 📌 0

IRP - Green Material Institute - France - Taiwan Ultra-nanostructured and Stretchable Biomaterials for the Conception of Bioelectronic DevicesSelf-Assembly of Glycopolymers

this work is part of the IRP project Green Institute :
irp-gmi.cnrs.fr

@cnrs.fr

26.02.2026 10:23 👍 0 🔁 0 💬 0 📌 0

Sugar-functionalized carbon nanotubes in aqueous dispersions: Tailoring interfaces for thermoelectric energy harvesting Herein, the application of a stable aqueous suspension of sugar-functionalized carbon nanotubes (CNTs) to thermoelectric energy harvesting is reported…

New pubnlication from R. Borsali and collaborators from National Taiwan University & Kyushu University :

"Sugar-functionalized carbon nanotubes in aqueous dispersions: Tailoring interfaces for thermoelectric energy harvesting"

www.sciencedirect.com/science/arti...

@cnrs.fr

26.02.2026 10:22 👍 0 🔁 0 💬 1 📌 0

Regulating supramolecular structure to enhance the ductility of regenerated cellulose films from ionic liquid solution Regenerated cellulose films suffer from inherent brittleness, restricting their practical use. Conventional plasticizer-based strategies can enhance d…

New publication from Y. Nishiyama and collaborators from Chinese Academy of Sciences:

"Regulating supramolecular structure to enhance the ductility of regenerated cellulose films from ionic liquid solution"

www.sciencedirect.com/science/arti...

@cnrs.fr

26.02.2026 10:20 👍 0 🔁 0 💬 0 📌 0

Renewal of the joint research laboratory between FunCell and the CNRS / Cermav - Centre de recherches sur les macromolécules végétales We are pleased to announce the continuation of our collaboration with FunCell. Following the creation of FunCell in 2020, based on research results from Cermav and a SATT Linksium maturation project, ...

We are pleased to announce the renewal of the joint research laboratory between FunCell and the CNRS / Cermav 👏

@cnrs.fr

12.02.2026 10:26 👍 1 🔁 0 💬 0 📌 0

The Pierre Süe Prize 2025 is awarded to Anne Imberty - Centre de recherches sur les macromolécules végétales Anne Imberty, CNRS Research Director, has been awarded the 2025 Pierre Süe Prize by the French Chemical Society (SCF). The SCF recognizes chemists who have contributed to the advancement of a field of...

The Pierre Süe Prize 2025 is awarded to Anne Imberty !

cermav.cnrs.fr/en/the-pierr...

@cnrs.fr
@cnrsalpes.bsky.social

16.01.2026 10:56 👍 1 🔁 0 💬 0 📌 0

AIS Biotech lève 1,5 million d’euros pour son spray nasal antigrippe La start-up grenobloise, qui développe un spray nasal à base de sucres pour cibler les virus responsables de la grippe a levé 1,5 million d’euros, notamment auprès de plusieurs investisseurs du territ...

La start-up AIS BIOTECH est à la une du Journal des Entreprises !

Ce projet est issu des travaux du laboratoire financés par le @cnrs.fr et Linksium, et accompagnés par CNRS Innovation

Toutes nos félicitations à l'équipe !

www.lejournaldesentreprises.com/article/ais-...

24.12.2025 09:11 👍 1 🔁 0 💬 0 📌 0

It also explores various alternative materials, including bio-based biodegradable polymers, as viable alternatives to conventional plastics.

@cnrs.fr

16.12.2025 08:03 👍 0 🔁 0 💬 0 📌 0

This book is aimed at specialists in environmental engineering, chemical engineering, and polymer chemistry, as well as the general public interested in scientific solutions to the problem of plastic pollution.

16.12.2025 08:03 👍 0 🔁 0 💬 0 📌 1

Plastics in the Oceans | Toward Sustainable Solutions | Jean-Luc Wertz Increasing plastic pollution, particularly in oceans, calls for a fundamental shift towards future-proof plastics throughout the circular economy. In a landmark

Proud of our colleague Serge Pérez who published that book with Jean-Luc Wertz et Jean-Pierre Mercier !

"Plastics in the Oceans"

www.taylorfrancis.com/books/mono/1... www.taylorfrancis.com/books/mono/1...

@cnrs.fr

16.12.2025 08:02 👍 3 🔁 3 💬 0 📌 1

Workshop “Wood and fibers” on December 15th and 16th, 2025 @ Cermav !

This workshop will focus on wood and its transport properties in relation to morphology.

More information and contact ➡️https://cermav.cnrs.fr/en/workshop-wood-and-fibers-on-december-15th-and-16th-2025-cermav/

05.12.2025 09:44 👍 0 🔁 0 💬 0 📌 0

Romain Bordage's PhD defense on December 15th, 2025 - Centre de recherches sur les macromolécules végétales Romain Bordage completed his PhD thesis entitled “Spontaneous and mechanically-assisted water transport in beech wood: investigation using X-ray tomography and digital volume correlation” under the jo...

Romain Bordage’s PhD defense on December 15th, 2025!

“Spontaneous and mechanically-assisted water transport in beech wood: investigation using X-ray tomography and digital volume correlation”

co-supervision @cermav.bsky.social & 3SR

Info. & abstract : cermav.cnrs.fr/en/romain-bo...

@cnrs.fr

25.11.2025 08:18 👍 0 🔁 0 💬 0 📌 0

Cermav - UPR 5301

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