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Hannah Josefine Jüllig

@hannahjuellig

PhD Student in the Long and Bickmore Labs 👩🏼‍🔬🧬 @IGC University of Edinburgh

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Posts 20.06.2025
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Latest posts by Hannah Josefine Jüllig @hannahjuellig

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📣 I'm excited to share our latest preprint!

We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫

Read about Array-CNCC here:
www.biorxiv.org/content/10.6...

@uoe-igc.bsky.social

28.01.2026 14:36 👍 48 🔁 13 💬 2 📌 1
Array-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling Facial development is highly sensitive to genetic and environmental perturbation, with craniofacial malformation associated with over one-third of congenital birth defects. The face arises during an early and largely inaccessible window of embryonic development, with a large contribution from transient and multipotent cranial neural crest cells (CNCCs). Assessment of the molecular and cellular mechanisms driving normal and disordered human facial development therefore relies greatly on the use of in vitro cellular models. Here, we adapted a neurosphere-based CNCC differentiation protocol to facilitate robust quantification of early specification and migration events. Introduction of single-cell aggregation with arrayed plating enabled standardisation of neurosphere size, growth and patterning. Inclusion of fibronectin coating enhanced the efficiency of neurosphere attachment and synchronicity of CNCC migration timing. To demonstrate application of the Array-CNCC method, we developed a strategy for mosaic co-culture, which can facilitate differentiation of wildtype untreated cells directly alongside cells exposed to distinct drug treatments or genetic alterations. Finally, we present a screening approach which we use to test the impact of distinct extracellular matrix components on neurosphere morphology, CNCC migration and gene expression. Together, the Array-CNCC method is highly amenable to quantitative phenotyping and screening approaches, enabling enhanced craniofacial disease modelling with both cellular and molecular readouts. ### Competing Interest Statement The authors have declared no competing interest. Medical Research Council, MC\_UU\_00035/12, MC\_ST\_00035 Wellcome Trust, https://ror.org/029chgv08, 227712/Z/23/Z

📣 Preprint alert!

I am happy to share that our neural crest manuscript is now available on BioRxiv! www.biorxiv.org/content/10.6...

19.01.2026 12:16 👍 5 🔁 5 💬 0 📌 0

A very nice highlight of our recent paper!

22.11.2025 08:06 👍 3 🔁 1 💬 0 📌 0
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Neanderthal DNA enhances our understanding of face development

This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...

10.11.2025 13:04 👍 21 🔁 7 💬 2 📌 2

Excited to share our new paper out today in Development! Check out Hannah’s fantastic post below for a summary of the findings ✨

journals.biologists.com/dev/article/...

10.11.2025 14:37 👍 13 🔁 1 💬 0 📌 0
Left to right: Kirsty Uttley, Hannah Long and Hannah Jüllig at the Institute of Genetics and Cancer, overlooking the city of Edinburgh. Photo credit: Connor Warnock.

Left to right: Kirsty Uttley, Hannah Long and Hannah Jüllig at the Institute of Genetics and Cancer, overlooking the city of Edinburgh. Photo credit: Connor Warnock.

To learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah Jüllig, as well as corresponding author, Hannah Long
doi.org/10.1242/dev....

10.11.2025 13:04 👍 12 🔁 4 💬 0 📌 0
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Dark genome holds clues to Neanderthal face shape | Institute of Genetics and Cancer | Institute of Genetics and Cancer Differences in a specific region of the Neanderthal genetic code may have contributed to their distinctive protruding jawline, a study suggests.

Find out how the dark genome holds clues to Neanderthal face shape and how this could help in future research into human disease in this new study from IGC researchers 👉 edin.ac/443d1j4
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social

10.11.2025 12:04 👍 3 🔁 3 💬 0 📌 1
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The #EMBOenhanceropathies workshop was truly outstanding - such a wonderful community to be part of and exciting science from start to finish! Group photo in front of Hindsgavl Slot @edinburgh-uni.bsky.social @uoe-igc.bsky.social - we had a blast! 🧬

20.06.2025 08:18 👍 28 🔁 2 💬 1 📌 0