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Lorenzo Lolli

@lorenzololli

Lead Researcher at Aspire Academy | Research Fellow at Manchester Metropolitan University | Views are my own

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Latest posts by Lorenzo Lolli @lorenzololli

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A comprehensive public health approach is needed to study the impact of digital technology on health Barely a day goes by without media and political concern about the impact of digital technology on health, particularly among young people. The publication of a recent government report, โ€œUnderstandin...

"Research should not only be independent of vested interests but must also be seen to be so"

My @bmj.com piece with @fphuk.bsky.social president Tracy Daszkiewicz argues we need a public health approach to study the impact of digital technology on health.

#CDOH

www.bmj.com/content/392/...

10.03.2026 16:42 ๐Ÿ‘ 20 ๐Ÿ” 12 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1
Online Studies
Psychological Science requires that authors who use samples from online data collection include a statement in the Method section explicitly addressing their approach to preventing and detecting automated or AI-generated responses.

Rationale

As large language models and other generative AI tools become more accessible, the risk of data contamination by non-human respondents has increased dramatically in research. Psychological science (and the social sciences generally) is particularly susceptible to this issue given its growing reliance on online data collection. Preventing automated responses during data collection and detecting them afterward often involve methodological trade-offs. For instance, technical barriers that aim to prevent LLM use (e.g., blocking copy-pasting functionalities) may eliminate behavioral indicators needed for detection (e.g., pasting rather than typing). This policy aims to enhance transparency and reproducibility of reported results by requiring authors to articulate their approach across both prevention and detection dimensions, enabling readers and reviewers to assess the likelihood of reported data being influenced by automated responses.

Scope

This policy applies to any submission with at least one study that includes data collected online without direct human supervision (e.g., via crowdsourcing platforms, student participants who complete the study online, online recruitment ads, or remote survey distribution tools).

Required Reporting

Authors must include in the Methods section either:

A statement confirming that procedures were in place to prevent and/or detect and exclude automated or AI-generated responses, including a description of those procedures (e.g., explicit participant instructions against LLM use, disabled copyโ€“paste functionality, CAPTCHA use, IP filtering, consistency checks, attention checks, adversarial prompting) as well as the types of automated responses that these procedures are suitable โ€ฆ

Online Studies Psychological Science requires that authors who use samples from online data collection include a statement in the Method section explicitly addressing their approach to preventing and detecting automated or AI-generated responses. Rationale As large language models and other generative AI tools become more accessible, the risk of data contamination by non-human respondents has increased dramatically in research. Psychological science (and the social sciences generally) is particularly susceptible to this issue given its growing reliance on online data collection. Preventing automated responses during data collection and detecting them afterward often involve methodological trade-offs. For instance, technical barriers that aim to prevent LLM use (e.g., blocking copy-pasting functionalities) may eliminate behavioral indicators needed for detection (e.g., pasting rather than typing). This policy aims to enhance transparency and reproducibility of reported results by requiring authors to articulate their approach across both prevention and detection dimensions, enabling readers and reviewers to assess the likelihood of reported data being influenced by automated responses. Scope This policy applies to any submission with at least one study that includes data collected online without direct human supervision (e.g., via crowdsourcing platforms, student participants who complete the study online, online recruitment ads, or remote survey distribution tools). Required Reporting Authors must include in the Methods section either: A statement confirming that procedures were in place to prevent and/or detect and exclude automated or AI-generated responses, including a description of those procedures (e.g., explicit participant instructions against LLM use, disabled copyโ€“paste functionality, CAPTCHA use, IP filtering, consistency checks, attention checks, adversarial prompting) as well as the types of automated responses that these procedures are suitable โ€ฆ

Maybe of interest: The submission guidelines of Psychological Science now demand an explicit statement on measures taken to reduce the risk of AI-generated responses for all online studies!

www.psychologicalscience.org/publications...

25.02.2026 12:08 ๐Ÿ‘ 124 ๐Ÿ” 53 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al โ€ขThe calculation of simple ratios is ubiquitous in biomedical health research.โ€ขRatios are formulated by dividing a numerator (Y) for a denominator (X) variable.โ€ขRatios are spurious if underlying assum...

Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 12:48 ๐Ÿ‘ 7 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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An Empirical Assessment of the Cost of Dichotomization of the Outcome of Clinical Trials We have studied 21โ€‰435 unique randomized controlled trials (RCTs) from the Cochrane Database of Systematic Reviews (CDSR). Of these trials, 7224 (34%) have a continuous (numerical) outcome and 14โ€‰211 (66%) have a binary outcome. We find that trials ...

Want to make your research more meaningful? Ornithology? Smear the lenses of your binoculars with vaseline. You may not be able to tell a hawk from an eagle but you wonโ€™t mistake a sparrow for an ostrich.
Clinical research? Why not use responder dichotomies?

pmc.ncbi.nlm.nih.gov/articles/PMC...

19.02.2026 07:44 ๐Ÿ‘ 9 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

for critique see here:
pubpeer.com/publications...

11.02.2026 21:15 ๐Ÿ‘ 8 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Improved Centile Estimation by Transformation And/Or Adaptive Smoothing of the Explanatory Variable A popular approach to growth reference centile estimation is the LMS (Lambda-Mu-Sigma) method, which assumes a parametric distribution for response variable Y$$ Y $$ and fits the location, scale and ....

๐™„๐™ข๐™ฅ๐™ง๐™ค๐™ซ๐™š๐™™ ๐˜พ๐™š๐™ฃ๐™ฉ๐™ž๐™ก๐™š ๐™€๐™จ๐™ฉ๐™ž๐™ข๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™—๐™ฎ ๐™๐™ง๐™–๐™ฃ๐™จ๐™›๐™ค๐™ง๐™ข๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐˜ผ๐™ฃ๐™™/๐™Š๐™ง ๐˜ผ๐™™๐™–๐™ฅ๐™ฉ๐™ž๐™ซ๐™š ๐™Ž๐™ข๐™ค๐™ค๐™ฉ๐™๐™ž๐™ฃ๐™œ ๐™ค๐™› ๐™ฉ๐™๐™š ๐™€๐™ญ๐™ฅ๐™ก๐™–๐™ฃ๐™–๐™ฉ๐™ค๐™ง๐™ฎ ๐™‘๐™–๐™ง๐™ž๐™–๐™—๐™ก๐™š. Rigby RA, Stasinopoulos DM, Cole TJ. Stat Med. 2026 Feb;45(3-5):e70414. doi: 10.1002/sim.70414.

onlinelibrary.wiley.com/doi/10.1002/...

09.02.2026 08:08 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Fascinating stuff. However, IMO, the value of double blind trials is not just dealing with patient- centred biases but physician-biases and this is often overlooked. www.linkedin.com/pulse/blind-...?

08.02.2026 06:41 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Die, Dichotomy We have studied 21 435 unique randomized controlled trials (RCTs) from the Cochrane Database of Systematic Reviews (CDSR).Of these trials, 7224 (34%) have a continuous (numerical) outcome and 14 211 (...

Die, Dichotomy.
www.linkedin.com/pulse/die-di...
A brief post encouraging you to read the original paper with @erik-van-zwet.bsky.social and @f2harrell.bsky.social .
onlinelibrary.wiley.com/doi/epdf/10....

05.02.2026 16:00 ๐Ÿ‘ 17 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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How to Do Bad Biomarker Research โ€“ Statistical Thinking This article covers some of the bad statistical practices that have crept into biomarker research, including setting the bar too low for demonstrating that biomarker information is new, believing that...

Judging by the poor quality of biomarker research I see reported in biomedical journals, my article "How to Do Bad Biomarker Research" must have been hugely influential: www.fharrell.com/post/badb/in... #Statistics #StatsSky #EpiSky

23.01.2026 12:41 ๐Ÿ‘ 36 ๐Ÿ” 10 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1
Post image Post image Post image Post image

Editor in Chief publishes eight articles in one issue of his (Scopus indexed) journal. Is that ethical?
๐Ÿงต

17.01.2026 08:15 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

โ€œYou will find that many alternative medicine enthusiasts are into proidiotics.โ€ Sayings of Confuseus

12.01.2026 07:25 ๐Ÿ‘ 8 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Assessing the properties of the prediction interval in random-effects meta-analysis | Research Synthesis Methods | Cambridge Core Assessing the properties of the prediction interval in random-effects meta-analysis

โ€œAssessing the properties of the prediction interval in random-effects meta-analysisโ€ www.cambridge.org/core/journal...

10.01.2026 07:10 ๐Ÿ‘ 2 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Our letter to editor about Caldwell et al (J Appl Physiol 139: 1220โ€“1227, 2025) is published: journals.physiology.org/doi/full/10....

There seemed misconceptions about variance comparison stats. We also commented on the author's โ€œSD of treatment effectsโ€. Suppl stuff: zenodo.org/records/1777...

09.01.2026 09:01 ๐Ÿ‘ 4 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

#neuroscience #biomedicine #researchintegrity

06.01.2026 11:47 ๐Ÿ‘ 6 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
An Open Letter to the BMJ Editorial Board to: Editor in chief, Kamran Abbasi , kabbasi@bmj.com ย  ย  ย Executive editor, Theodora Bloom , tbloom@bmj.com ย  ย  ย Head of research, Elizab...

How long should it take to retract a paper with incontrovertible signs of data fabrication? Sleuths think 2 months is too long, particularly when clinical risks are involved. deevybee.blogspot.com/2026/01/an-o...
#retraction #stemcells #cardiology
@erictopol.bsky.social

05.01.2026 09:38 ๐Ÿ‘ 70 ๐Ÿ” 32 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 7
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Building an AI Scientist Hertz Fellow Sam Rodriguez launched FutureHouse, a nonprofit research lab working toward building an AI scientist or AI systems that can automate scientific research in biology and other complex scien...

โ€œAn AI scientist, for example, could figure out how the human brain works, or deliver any gene to any cell in the body.โ€

Yeah and a magic pony could shit bricks of 24k gold and piss a highly concentrated solution of pure heroin.

30.12.2025 00:29 ๐Ÿ‘ 719 ๐Ÿ” 132 ๐Ÿ’ฌ 41 ๐Ÿ“Œ 13
Post image

Most researchers would receive more recognition if assessed by article-level metrics than by journal-level metrics buff.ly/EhQn7JQ

30.12.2025 16:09 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Figure 1: The Rothman-Dahly Evidence Pyramid (original version)

An equilateral triangle with a small blue section labelled "Thoughtful, well-conducted studies of any design" at the top, with the remaining space colored red and labelled "The other shit"

Figure 1: The Rothman-Dahly Evidence Pyramid (original version) An equilateral triangle with a small blue section labelled "Thoughtful, well-conducted studies of any design" at the top, with the remaining space colored red and labelled "The other shit"

โ€ชIt has a name now ๐Ÿ˜œ

Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.

โœ… zenodo.org/records/1808...

โœ… pubmed.ncbi.nlm.nih.gov/24452418/

29.12.2025 11:19 ๐Ÿ‘ 224 ๐Ÿ” 75 ๐Ÿ’ฌ 9 ๐Ÿ“Œ 12

The best bit about the show Tipping Point is when the host, Ben Shephard, says "let's find out what would have happened if you'd decided to play". There's always a nagging doubt at the back of my mind: that's not really what *would* have happened, is it?

19.12.2025 09:28 ๐Ÿ‘ 3 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
โ€œRe-examination of the 3/4-law of metabolismโ€ and โ€œToward a metabolic theory of ecologyโ€ | Statistical Modeling, Causal Inference, and Social Science

โ€œRe-examination of the 3/4-law of metabolismโ€ and โ€œToward a metabolic theory of ecologyโ€
statmodeling.stat.columbia.edu/2025/12/18/r...

18.12.2025 15:03 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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More than half of researchers now use AI for peer review โ€” often against guidance Policies should reflect the โ€˜new realityโ€™ of researchersโ€™ increasing reliance on tools that can summarize manuscripts and draft reports.

Yeah. And before this, half of reviewers were submitting trivial, short reviews that either said "looks good to me" or "this is excrement". This is why reviews should be part of the public record for any paper.

www.nature.com/articles/d41...

16.12.2025 08:57 ๐Ÿ‘ 29 ๐Ÿ” 8 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 3
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Studying the dynamics of mandibular growth spurts in individuals with Class I and Class II skeletal growth patterns using the Bayesian superimposition by translation and rotation (SITAR) model AbstractBackground. Comparing the mandibular growth patterns of Class I and Class II children offer valuable insights into adolescent growth dynamics that

๐—ฆ๐˜๐˜‚๐—ฑ๐˜†๐—ถ๐—ป๐—ด ๐˜๐—ต๐—ฒ ๐—ฑ๐˜†๐—ป๐—ฎ๐—บ๐—ถ๐—ฐ๐˜€ ๐—ผ๐—ณ ๐—บ๐—ฎ๐—ป๐—ฑ๐—ถ๐—ฏ๐˜‚๐—น๐—ฎ๐—ฟ ๐—ด๐—ฟ๐—ผ๐˜„๐˜๐—ต ๐˜€๐—ฝ๐˜‚๐—ฟ๐˜๐˜€ ๐—ถ๐—ป ๐—ถ๐—ป๐—ฑ๐—ถ๐˜ƒ๐—ถ๐—ฑ๐˜‚๐—ฎ๐—น๐˜€ ๐˜„๐—ถ๐˜๐—ต ๐—–๐—น๐—ฎ๐˜€๐˜€ ๐—œ ๐—ฎ๐—ป๐—ฑ ๐—–๐—น๐—ฎ๐˜€๐˜€ ๐—œ๐—œ ๐˜€๐—ธ๐—ฒ๐—น๐—ฒ๐˜๐—ฎ๐—น ๐—ด๐—ฟ๐—ผ๐˜„๐˜๐—ต ๐—ฝ๐—ฎ๐˜๐˜๐—ฒ๐—ฟ๐—ป๐˜€ ๐˜‚๐˜€๐—ถ๐—ป๐—ด ๐˜๐—ต๐—ฒ ๐—•๐—ฎ๐˜†๐—ฒ๐˜€๐—ถ๐—ฎ๐—ป ๐˜€๐˜‚๐—ฝ๐—ฒ๐—ฟ๐—ถ๐—บ๐—ฝ๐—ผ๐˜€๐—ถ๐˜๐—ถ๐—ผ๐—ป ๐—ฏ๐˜† ๐˜๐—ฟ๐—ฎ๐—ป๐˜€๐—น๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฎ๐—ป๐—ฑ ๐—ฟ๐—ผ๐˜๐—ฎ๐˜๐—ถ๐—ผ๐—ป (๐—ฆ๐—œ๐—ง๐—”๐—ฅ) ๐—บ๐—ผ๐—ฑ๐—ฒ๐—น

15.12.2025 13:45 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Weekend reads: โ€˜The fall of a prolific science journalโ€™; Clinical trials by โ€˜super-retractorsโ€™; โ€˜How to Study Things That May Not Existโ€™ Giving Tuesday was this week, and, like many organizations, we asked for your support. The work we do is funded in part by your donations. If you value our work in rooting out scientific fraud and โ€ฆ

Weekend reads: โ€˜The fall of a prolific science journalโ€™; Clinical trials by โ€˜super-retractorsโ€™; โ€˜How to Study Things That May Not Existโ€™

06.12.2025 16:21 ๐Ÿ‘ 14 ๐Ÿ” 7 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

OMG - itโ€™s like the old days of Hindawi AI gobbledegook sandwiches
www.nature.com/articles/s41...

29.11.2025 18:48 ๐Ÿ‘ 15 ๐Ÿ” 10 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

More nonsense from Scientific Reports
www.nature.com/articles/s41...
This article may be many things, but scientific it ainโ€™t

29.11.2025 18:22 ๐Ÿ‘ 19 ๐Ÿ” 7 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 3

this is one of my favourite observations about sample size calculations. (afaik first articulated by Miettinen in 1985)

25.11.2025 10:56 ๐Ÿ‘ 77 ๐Ÿ” 21 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 2

For some research studies the optimal sample size should be estimated at 0

25.11.2025 10:51 ๐Ÿ‘ 62 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 2
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"Sports and exercise sciences journals under scrutiny for predatory publishing" | Lorenzo Lolli posted on the topic | LinkedIn โ€œAs the investigation proceeded, it became clear that ๐™– ๐™—๐™ง๐™ค๐™–๐™™ ๐™–๐™ฃ๐™™ ๐™จ๐™ค๐™ฅ๐™๐™ž๐™จ๐™ฉ๐™ž๐™˜๐™–๐™ฉ๐™š๐™™ ๐™ฃ๐™š๐™ฉ๐™ฌ๐™ค๐™ง๐™  of about 35 authors ๐™ฌ๐™š๐™ง๐™š ๐™ฅ๐™ค๐™ฉ๐™š๐™ฃ๐™ฉ๐™ž๐™–๐™ก๐™ก๐™ฎ ๐™˜๐™ค๐™ก๐™ก๐™ช๐™™๐™ž๐™ฃ๐™œ over a very large number of journals and published papers, a frac...

All very important stuff so actual and relevant to a field as the sports and exercise sciences having the potential to reshape the canons of sleuthing given the consolidated practices and quite solid โ€œ๐™ฅ๐™–๐™ฅ๐™š๐™ง ๐™ข๐™ž๐™ก๐™ก๐™จ ๐™ฃ๐™š๐™ฉ๐™ฌ๐™ค๐™ง๐™ ๐™จโ€ plaguing the field in recent years

www.linkedin.com/posts/lorenz...

15.11.2025 12:51 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

โ€œThe worrying thing is that most of the published literature is ๐™ฃ๐™ค๐™ฉ ๐™จ๐™ค ๐™ฉ๐™ง๐™–๐™ฃ๐™จ๐™ฅ๐™–๐™ง๐™š๐™ฃ๐™ฉ and one wonders ๐—ต๐—ผ๐˜„ ๐—บ๐—ฎ๐—ป๐˜† ๐—ฝ๐˜‚๐—ฏ๐—น๐—ถ๐˜€๐—ต๐—ฒ๐—ฑ ๐—ฎ๐—ฟ๐˜๐—ถ๐—ฐ๐—น๐—ฒ๐˜€ ๐—บ๐—ถ๐—ด๐—ต๐˜ ๐—ต๐—ฎ๐˜ƒ๐—ฒ ๐—ฏ๐—ฒ๐—ฒ๐—ป ๐—ฟ๐—ฒ๐—ท๐—ฒ๐—ฐ๐˜๐—ฒ๐—ฑ ๐—ถ๐—ณ ๐—ณ๐˜‚๐—น๐—น ๐—ถ๐—ป๐—ณ๐—ผ๐—ฟ๐—บ๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐˜„๐—ฒ๐—ฟ๐—ฒ ๐—ฎ๐˜ƒ๐—ฎ๐—ถ๐—น๐—ฎ๐—ฏ๐—น๐—ฒ.โ€ - spot on @deevybee.bsky.social.

15.11.2025 12:51 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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The potential and limits of scrutiny in medical research In a recent lecture Chris Whitty, Englandโ€™s chief medical officer, talked about how setbacks driven by misinformation can be temporary and how evidence and data can rebuild confidence. He was speaking...

โ€œ..Our capacity to manage potential research misconduct is being overwhelmed. Automated pre-submission checks help but are far from infallible, which leaves responsible journals considering how best to bolster peer review, both before and after publication, and to force greater transparency.โ€

15.11.2025 12:28 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0