@audeber
PI at Institut Pasteur Evolution, immunity, genomics, microbiolgy. Into immunity in bacteria and its conservation in eukaryotes. Advocate for more inclusive sciences https://research.pasteur.fr/en/team/molecular-diversity-of-microbes/
After >10 years of our lab studying bacterial cGAS-like enzymes, @hobbslabutah.bsky.social finally reconstitutes viral sensing in vitro and discovers how these ancient receptors sense phage protease enzymes to detect virion assembly and activate antiviral immunity
www.biorxiv.org/content/10.6...
This is a fantastic paper with a very creative computational approach, that should inspire many "AlphaFlod-predicted shapes" screens.
Great friday read ππ
Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes
www.science.org/doi/10.1126/...
Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration!
Linking below previous thread on our findings
Congrats!!!!
Very excited to see this work out today!
Discovering viral immune antagonists directly from predicted protein structures. π€© www.science.org/doi/10.1126/...
Huge thanks to the amazing collaborators! π€
β‘οΈ preprint from the lab! Bacteria have loads of antiviral defences in their mobile genetic elements (MGEs). So when MGEs move between bacteria, the defences move with them, generating a fast turnover of defences in bacteria. But what about the antiviral defence turnover in the MGEs themselves? π€
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Fantastic collaboration w/ @dbikard.bsky.social @audeber.bsky.social @rayanchikhi.bsky.social labs led by @jmouradesousa.bsky.social : We assessed the rates of variation of anti-phage systems in P4-like satellites and P2 helper phages. Quick conclusion: Huge variation! We focus on 4 key questions/5
π€©π€©
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).
A brief 𧡠(carried over from the old place)
Hi everyone, I am preparing a lecture and was thinking of the milestone papers in the field of bacterial immunity.
I was curious which ones would you include ?
Thanks!
Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps:
www.cell.com/cell/fulltex...
Congratulations!!!!!!!
I am incredibly honored to receive this recognition from the Michelson Medical Research Foundation for our work on innate immune signaling.
www.michelsonmedicalresearch.org/news/michels...
Beautiful structures, poetic name and great paper !
Free readcube link to her paper: rdcu.be/e4A7X
We'll be there with many lab members, sharing new stories, we'll be very happy to get feedback on :)
Really looking forward.
Aude Bernheim @audeber.bsky.social and Eugene Koonin discuss one of most interesting questions in the field connecting bacterial and animal immunity!
www.nature.com/articles/s41...
The immune systems paradox
Some widespread prokaryotic immune systems are absent in eukaryotes, whereas relatively rare ones became central to eukaryotic innate immunity
@audeber.bsky.social & E. Koonin hypothesize the answer is #HGT
shareable link: rdcu.be/e2EmD
www.nature.com/articles/s41...
Two independent super-elegant studies from Maxwell & Laub labs find immune proteins that sense infection by binding to oligomeric phage protein rings (i.e phage portal), using them as a scaffold to assemble into their active immune effector form π€―
Highly recommend read! π€πl
We found a new mode by which bacteria deplete NAD+ to protect from phages. And then we found how phages overcome this defense
Discovered by talented biochemist Dr Ilya Osterman, read the preprint: tinyurl.com/Narp-ap
A thread π§΅
𧬠Metabolic arms race continues!
We discovered a new NADβΊ-depleting bacterial immune system aRES and phage enzymes that overcome it.
Our preprint is out: www.biorxiv.org/content/10.6...
π¨ Hiring Alert! π¨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: π¦ Synthetic Biology andπ‘οΈ Bacterial Immunity. Come do great science with us in the middle of Paris! π«π·π₯ research.pasteur.fr/en/job/postd...
Great new story from Sophie Helaine and Molly Sargen!
www.helainelab.com
Yay!!!!! Awesome. Congratulations.
Join us in congratulating Philip J. Kranzusch (@kranzuschlab.bsky.social) of @danafarber.bsky.social and @harvardmed.bsky.social, winner of the 2026 NAS Award in Molecular Biology for his groundbreaking work advancing understanding of innate immunity! www.nasonline.org/award/nas-aw... #NASaward
Deadline is approaching (Feb 9) to apply for a PI position at Institut Pasteur. Come join us and contribute to an amazing scientific environment!!!
π¦ 𧫠Envie d'en savoir plus sur la Microbiologie et de dΓ©couvrir l'Institut Pasteur ?
Rejoignez nous pour confΓ©rence scientifique grand public, accompagnΓ©e dβune performance artistique le 27 janvier Γ 18h! Inscrivez-vous :)
research.pasteur.fr/fr/event/con...
Our new paper is out in Nature π. We show that m1Ξ¨ in mRNA vaccines doesnβt just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way π§¬
Full paper : rdcu.be/eY5gx
Fascinating work on genomic islands!
Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive.
Here we explore the conjugative capacity of these mysterious Genomic Islands.
www.biorxiv.org/content/10.6...