> paper claims astonishing progress on protein folding problem
> ask if it’s interesting proteins or villin headpiece denatured with urea
> they say results are robust to protein sequence properties
> open the pdf
> villin headpiece in urea
My most important scientific mentors and the scientists I most look up to are mostly women: Veronica Vaida, Jenny Glusker, Ann Skalka, Janet Thornton, Jane Richardson, Helen Berman. Happy International Women’s Day! @asbmb.bsky.social
Nobody told me about any of this in high school, which is bad in some ways but good in others.
Popular perception of how science progressed in the early 20th centuries is mangled by the world wars, which interrupted foundational work, chanted the language of global scientific discourse, and created nat sec incentives favoring obfuscation of anything close to nuclear science+cryptography
sometimes when i put “best” at the end of an email i don’t really wish them my best
Two brothers from South Texas and their high school mariachi bandmates were recognized by their congresswoman last June for winning a state mariachi competition. Nine months later, the brothers, along with their parents and younger brother, are in ICE detention and facing deportation.
Did not expect this:
"To illustrate this evolution, a phylogenetic tree constructed from the similarity of word content of abstracts shows a remarkably regular ‘ladder-like’ topology, with each successive year being most similar to its preceding year"
from journals.biologists.com/bio/article/...
Sort of funny now that I think about it how the cult of linear algebra nerds can be so confident sometimes that things can be described with scalar quantities. Almost no rhyme or reason to when or why
Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes
www.science.org/doi/10.1126/...
Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration!
Linking below previous thread on our findings
I’m sick just thinking about it
the web is a customer service medium, thats why its so unpleasant imo
like trying to have a good time with the other people in line to return a defective vacuum and a yeti rambler to target
Why would I try
Everybody thinks that everybody else understands linear algebra better than they do
Ime anything that starts with “undergraduate linear algebra tells you” and ends with something people care about should be a paper. Linear algebra is where the Common Knowledge caps out currently
[channeling cosma] most priors are smoothing
They will give Kaitlin computer 😈
It’s rumored that I am in NYC
Ayatollah Ali Khamenei, the supreme leader of Iran, was killed Saturday after the US and Israel launched airstrikes on Iran, according to President Donald Trump. He was 86.
So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore
Great work from post-doctoral fellow @joanzone.bsky.social:
New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation.
doi.org/10.64898/202...
Broke: dead internet theory
Woke: undead internet theory
REAL
I’m always saying this
A friend has managed to host a weekly watch party that has thus far made it all the way through “the evil that men do”
I’d love to read this. Would you be willing to email me a PDF? I can provide my email over DM
hi guys I know I haven't been very active lately, and I don't talk about where I'm from often, but the government made some really scary announcements today so I thought I'd share to let everyone know what's happening. here are some posts from twt for context
Our paper is now out in Nature:
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres.
1/14
wtf I did NOT know this
I have yet to see anything more impressive than those side projects programmers used to show off on hackernews but maybe I’m not looking in the right places.
