Using behavioral screening & machine learning on 24 Drosophila models of familial forms of #Parkinsons, researchers identify clusters that converge on (1) mitochondrial function; (2) retromer/vesicle trafficking and proteostasis/autophagy.
www.nature.com/articles/s41...
New research provides a comprehensive behavioral & physiological assessments of non-motor & motor symptoms in mice injected with αSyn-PFFs in the duodenum at different time points
link.springer.com/article/10.1...
A 5-year longitudinal study of 345 PPMI participants highlights the heterogeneity in early #Parkinsons defined by clinical diagnostic criteria, underscoring the importance of shifting to biologically & functional impairment defined inclusion criteria
onlinelibrary.wiley.com/doi/10.1002/...
A multi-ancestral investigation of #Parkinsons was conducted to examine the impact of genome-wide homozygosity on disease risk & age at onset (AAO); Results highlight distinct patterns of runs of homozygosity enrichment associated with AAO
movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1...
Vima Therapeutics announces that the 1st Dystonia patient has been dosed in their Phase 2 study; Plus they announce extension of their Series A to $100 Million to help advance potential first-in-class oral therapy for dystonia & #Parkinsons
vimatx.com/2026/03/11/v...
Genetic analysis of a large-scale population-based Taiwanese cohort highlights both shared & ethnicity-specific #Parkinsons risk loci & identifies PRDM15 as a potential novel contributor to PD dementia
www.thelancet.com/journals/lan...
New "review explores non-profit funder approaches to reducing technical, policy, & cultural barriers to data interoperability across #Parkinsons & related disorders to improve research data findability, accessibility, interoperability, & reliability"
journals.sagepub.com/doi/full/10....
Using genotyping array data of 661 South African #Parkinsons cases & 737 controls, researchers conduct a polygenic risk score analysis; They highlight how ancestry composition & study design affect risk estimation in diverse populations
journals.plos.org/plosgenetics...
A new qualitative study explores cultural & systemic barriers in #Parkinsons diagnosis, treatment, & research participation among Asian Americans; “We have information about Parkinson's in Spanish...We don't have anything in Vietnamese.
journals.sagepub.com/doi/10.1177/...
Neuropath. & molecular analyses on 47 postmortem substantia nigra samples implicate ferroptosis (& to a lesser extent necroptosis) in #Parkinsons cell death; Researchers propose a “2-hit” model: early synucleinopathy amplified later by a neuromelanin-iron
onlinelibrary.wiley.com/doi/10.1002/...
Curious: Researchers report that a macrophage ferritin heavy chain—⍺-synuclein regulatory axis modulates ferroptosis during kidney injury; Monomeric SNCA exhibits ferrireductase activity, amplifying redox cycling and promoting ferroptotic cell death
insight.jci.org/articles/vie...
Researchers analysed stearoyl-coenzyme A desaturase & monounsaturated fatty acids-enriched lipids in the periphery of patients with #Parkinsons; They found elevated MUFA content in 4 lipid classes & higher SCD levels in PD
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Casma Therapeutics has announced that they have received additional funding support ($7.6M) from the Michael J Fox Foundation to support IND-enabling activities for their first-in-class TRPML1 agonist, CSM-101, targeting lysosomal dysfunction in #Parkinsons
www.casmatx.com/2026/03/10/c...
A new "Delphi consensus provides a set of expert-derived, clinically applicable recommendations to support proactive & individualised management of #Parkinsons"; Supports earlier initiation of adjunctive therapies, guided by the 4-1-0 criteria
journals.sagepub.com/doi/10.1177/...
Pioneering 1915 film from Spain on movement disorders. such as Parkinsonism, Huntington's disease, & Paradoxical Kinesia
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New viewpoint explores moving beyond the Homunculus with the new research on the “somato-cognitive action network” (SCAN) in #Parkinsons
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New research finds no significant difference in lymphocyte count or neutrophil-to-lymphocyte ratio between patients with #Parkinsons (vs controls) in an ethnically diverse East London population
www.jns-journal.com/article/S002...
3. Peripheral biofluids clearly have great potential as disease markers, e.g. biomarkers of metabolism such as TAFA5 peripherally
2. Biomarkers of neuronal loss, such as neurofilament light, reliably distinguish the rapidly neurodegenerative synucleinopathy MSA from controls; however, with advancing disease severity, this relationship is not linear
Three key findings:
1. Levels of ‘multiple’ aggregating proteins differ between #Parkinsons disease & MSA from controls in peripheral biofluids. In particular, oligomeric alpha-synuclein can be directly detected & quantified using the NULISA panel
New paper used the nucleic acid-linked immuno-sandwich assay CNS disease panel to test biosamples from 161 #Parkinsons patients, 43 MSA patients & 39 controls & identify 3 classes of proteins that differ between PD & controls
academic.oup.com/braincomms/a...
New research finds that oral treatment with Faecalibacterium prausnitzii, which is depleted in the #Parkinsons patient microbiome, improves motor deficits in α-synuclein overexpressing (Thy1-ASO) mice
www.nature.com/articles/s41...
Weekend reading: Two decades of induced pluripotent stem cell research - from discovery to diverse applications - by Shinya Yamanaka
(I can remember when his seminal paper was published & was rather shocked by this title!)
www.cell.com/cell-stem-ce...
"LRRK2-mediated increase in GCase activity under inflammatory conditions could allow microglia to better degrade excess glucosylceraminde & glucosylsphingosine, thus underlying a protective effect of LRRK2 kinase activity in GBA1-associated #Parkinsons"
More on the potential protective effect of LRRK2 variants in GBA1-PD: Researchers demonstrate that in response to IFNγ-induced inflammatory stimulation of #Parkinsons-patient derived microglia, LRRK2 kinase & GCase activities are positively correlated
www.nature.com/articles/s41...
Researchers develop genetically encoded fluorescent reporters to visualise #Parkinsons -associated α-Synuclein inclusions in live mouse brains, enabling the measurement of the pathological effects of α-Synuclein inclusions in single neurons
www.cell.com/cell/fulltex...
New review explores TREM2 in neurodegeneration; I think the #Parkinsons data is a little more mixed than indicated, but a useful overview nonetheless
www.nature.com/articles/s41...
Good to see this issue being openly discussed - #Alzheimers drug developers accuse clinical trial sites of faking data (& the problem is probably not limited to Florida)
www.science.org/content/arti...
More N-acetyl-l-leucine data!
Preclinical work finds NALL treatment upregulated lysosomal, mitochondrial, and synaptic proteins in #Parkinsons patient cells;⬆️glycosylated DAT, synaptic membrane-associated synaptojanin-1, & synaptic vesicle endocytosis
www.jci.org/articles/vie...
A Danish nationwide cohort (3.2M with 36K PD cases) study reports that long-term exposure to air pollution is associated with #Parkinsons incidence; PM2.5, BC, & NO2=statistically signif +ve association; O3w = null associated with incident PD
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
