Jim Mansfield

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

🚨3-year Postdoc Position @halloulab.bsky.social (Kennedy Institute, Oxford) - on Spatial Biology & Bioinformatics of Fibrosis🚨

An exciting project combining #SpatialTranscriptomics & #Mechanobiology👇:

shorturl.at/LLS5r

Deadline: 16 March - Please RT 📢!

@kiroxford.bsky.social @ox.ac.uk

Now accepting Late-Breaking Poster Abstracts for CYTO 2026! Join us and share the latest findings with the global cytometry community. Don’t miss this opportunity to showcase cutting-edge science at the premier cytometry conference! Deadline: April 13th www.cytoconference.org/abstracts.html

Exclusive: Read the draft executive emergency order for Trump to take control of elections Lawyers and legal experts explicitly said that such an order is blatantly unconstitutional.

EXCLUSIVE: A draft executive order that would allow Trump to take unprecedented control over federal elections is reportedly being circulated with the White House.

Democracy Docket obtained a copy.

Read the full, 17-page order below👇

Stanley will never have this much trade value ever again

People INSIDE the Trump administration placed bets on a war they knew was coming, and profited.

Aside from the complete moral corruption of betting upon war, this is so unethical that it boggles the mind.

This may be the best AI product ever.

NSF officials break silence on how AI and quantum now drive agency grantmaking Leaders acknowledge White House role in controversial moves

The National Science Foundation is systematically being converted to the National AI and Quantum Research Foundation.

“I see it as the administration exerting political control over what has traditionally been NSF’s ability to fund the best science.”

NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true.

Here is a graph showing how many fewer new funding opportunities that NIH has posted over time.

-91%, a trend that started on Jan 2025.

Scientists face fallout for past associations with Epstein Jack Horner, who was a consultant for the Jurassic Park films, is among the researchers whose work or careers have been affected because of revelations from newly released documents.

Several scientists who are linked to convicted sex offender Jeffrey Epstein in files released last month are now facing consequences.

go.nature.com/4qXFkYS

Canada is the first non-European country to be granted membership in SAFE. This is unlocking new export markets abroad for producers across Canada’s defence industry and better equipping our military with the resources they need.

Motion to stop referring to it as Next Generation Sequencing. That's like saying The Matrix is a recent movie

Kids born the same year that the term “RNA-seq” was coined are heading to college this fall. We are all unspeakably ancient.

Check out our new paper!

iCLAP: an innovative method for integrable codetection
of low-abundance antigens with highplex
immunostaining

Read more about iCLAP here: www.nature.com/articles/s41...

Have you produced beautiful images as part of your cell biology research?

Then enter our image competition!

bscb.org/competitions...

Deadline 31st March

Check out last year's winner 'Brainbow' by Alvaro Castano

America needs a Surgeon General who follows the science, not trending conspiracies and pseudoscience. Tell your Senator to vote against Casey Means as our nation’s doctor!

One week left to register to the Bioimage Analysis with AI course in Pasteur!

This June, 1 - 5.

I give a bit more details in the thread below
👇

📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’

📅22-25 June 2026
📍CRUK Scotland Institute, Glasgow
🎟️Early Bird registration closes on 1 April
🔗 www.beatsonconference.org

#BICC2026 #CancerResearch #Immunology

This is more than 10.5 NIH budgets.

Absolutely outrageous when they gutted NSF and destroyed USAID.

For what?

Webinar at EMBL-EBI: Mapping tissue remodelling using sequencing-based spatial transcriptomics. 4 March 2026, 14:30-15:30 UK time. Speaker: Ricardo Ramirez, EMBL-EBI

Join us next week for the third free webinar in our spatial transcriptomics series: www.ebi.ac.uk/training/eve...

Ricardo Ramirez (EMBL-EBI) presents 'Mapping tissue remodelling using sequencing-based spatial transcriptomics' on 4 March| 14:30 UK time.

@saezlab.bsky.social
🧬🖥️

The political effects of X’s feed algorithm - Nature Among users initially on a chronological feed, 7 weeks of exposure to X’s algorithmic feed in 2023 shifted political attitudes and account-following behaviour in a more conservative direction compared...

Twitter/X "promotes conservative content and demotes posts by traditional media...algorithm substantially shifts attitudes towards more conservative opinions" www.nature.com/articles/s41...

Another thing to add to the Dem platform: all of these contracts were plainly procured through fraud, not one of them will be honored, and all culpable parties will be prosecuted.

This isn't a "radical" demand, it's the bare minimum required to re-establish the rule of law.

News article that reads: Canadian passport holders can travel to China visa-free starting this week

We’re renewing Canada’s relationship with China.

As part of our new strategic partnership, China is granting visa-free travel for Canadians.

America’s Future Is Hungary MAGA conservatives love Viktor Orbán. But he’s left his country corrupt, stagnant, and impoverished.

Remember: Viktor Orban has built a corrupt, stagnant Hungary that is much poorer than it should be

www.theatlantic.com/magazine/arc...

Postdoc alert in spatial biology!

Building upon our previous work with MSI cancers (e.g. de Vries et al, Nature, 2023), the Voest Group at the NKI is hiring a (fully funded) postdoctoral fellow with strong expertise in spatial cancer biology.

Learn more / apply here: www.nki.nl/careers-stud...

The Jets’ two best forwards are very good. But the international performance/decisions and how the Jets perform when it leans heavily on them should tell us something.

A lot of #NHLJets fans are overrating them.

Happy Flag Day, Canada 🇨🇦

A new systematic analysis of intermittent fasting from 22 randomized trials shows no advantage for weight loss or other outcomes compared with regular diet advice
www.cochranelibrary.com/cdsr/doi/10....

Assistant Professor (Tenure Track) of Computational Immunology

join our faculty at D-BSSE, ETHZ in Basel, Switzerland! New assistant prof position (tenure-track) in computational immunology, please share or apply. ethz.ch/en/the-eth-z...

Trump official overruled FDA scientists to reject Moderna's flu shot FDA's top vaccine regulator, Vinay Prasad, is known for overruling scientists.

Moderna is at least the ninth company to have received a surprise rejection from Vinay Prasad and his team.