Yehuda M. Danino

Mapping the genetic landscape across 14 psychiatric disorders - Nature Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

A study in Nature finds that five groups of disorders share most of their genetic risk in a screen of 14 psychiatric conditions, including depression, anxiety, and schizophrenia. The findings could help to improve diagnoses and lead to new treatments that work across several conditions. 🧬 🧪

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress - Nature Neuroscience Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.

Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...

Amazing Igor! Congrats!

Don’t miss the Early Career Showcase in Lisbon!

With 16 inspiring talks, interactive networking, and a relaxed, collaborative vibe, it’s a unique chance to explore cutting-edge cancer research and connect with peers.

Learn more: 2025.eacr.org/cancer-resea...

Great new field.

Welcome to BlueSky @jamchemsoc.bsky.social !

Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner

#chembio #AcademicSky #SciSky

Congrats!!

G-quadruplexes and their unexpected ability to fold proteins | PNAS G-quadruplexes and their unexpected ability to fold proteins

Have a look at our newest commentary in @pnas.org :

"G-quadruplexes and their unexpected ability to fold proteins"

Full text: www.pnas.org/doi/10.1073/...

#G4 #quadruplex #proteins #folding

G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...

Very late with my response... congrats!! All your efforts paid off!

Who made the mRNA vaccine? Measuring division of labor in therapeutic innovation go.nature.com/4eS8YJj

Single-molecule states link transcription factor binding to gene expression - Nature A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...

Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes Alirzayeva et al. find that ALS-related mutant FUS gains interaction with PARP1 and histone H1.2. Reducing either PARP1 activity or H1.2 levels prevents pathological changes in human motor neurons and...

New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports... #ALS

🧬 🖥️ Thrilled to share our recent work on TME heterogeneity, published on iScience:

t.co/whajXd0SjU

A joint effort with Federica Eduati's lab
Follow the thread for more🧵👇

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Hii:) can you join me please? Thanks!

Lab-Grown Human Immune System Model Uncovers Weakened Response in Cancer Patients To better understand why some cancer patients struggle to fight off infections, Georgia Tech researchers have created tiny lab-grown models of human immune systems.

That's a really interesting system from Georgia Tech. Immune Organoids! The research team used synthetic hydrogels which can make a microenvironment for B cells, isolated from human tonsils and blood, to mature and produce antibodies.
Published in Nature Materials.
news.gatech.edu/news/2024/11...

Download our database of 313 different postdoctoral fellowships.

For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).

Download our database here: research.jhu.edu/rdt/funding-...

I would love to be added please:) thank you for this starter pack! @dpastoors.bsky.social

Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705

BlueSky: A Guide for Scientists by @jacoates.bsky.social

#AcademicSky #EduSky 🧪

go.bsky.app/KxWyLE4

Trying to put together a starter pack for journals!

.. by the way, I also created starter pack focused on DNA and RNA G-quadruplexes #G4 and included some buddies @sebastien-britton.bsky.social @granzhan.bsky.social @drzoewaller.bsky.social @paeschkelab.bsky.social @jschneek.bsky.social
Contact me if interested!
go.bsky.app/4VgiGa4

@shrinivaslab.bsky.social how can I join?