@yashshukla
Molecular biologist exploring protein translation & early development in C. elegans 🧬 | Ribosome profiling enthusiast | Investigating embryonic cell fate decisions @UT Austin | Cat dad 🐱 #opentowork #openforpostdoc
Post 5/5:
🔬 For fellow C. elegans researchers: Our dataset is at GSE281412 and I'm working on tools to make it more accessible.
Paper: cell.com/cell-reports/fulltext/S2211-1247(25)00549-2
#DevelopmentalBiology #CelegansResearch #Science
Post 4/5:
This helps us understand one of biology's coolest tricks: how simple beginnings lead to complex, organized life forms through precise molecular choreography. 🪱➡️🐛
The timing and location of protein production is everything in early development.
Post 3/5:
What we discovered:
Different developmental stages have distinct protein production "fingerprints"
Where mRNAs are located in the cell affects how efficiently proteins get made
A regulator called OMA-1 controls hundreds of maternal recipes simultaneously
Post 2/5:
We used ribosome profiling to watch protein-making during the first few cell divisions.
Think of it like watching cellular cooks (ribosomes) follow recipe cards (mRNAs) left by mom, while the master cookbook (DNA) stays closed. 🧬👩🍳
How do tiny worm embryos decide which cells become muscle, nerve, or gut - all without reading any new DNA? 🤔
Our new Cell Reports paper explores this fascinating question using C. elegans embryos.
cell.com/cell-reports/fulltext/S2211-1247(25)00549-2
🧵 Thread below 👇
Ever wondered how several individual RBPs cooperate to repress translation?
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Awesome stuff! I use patchwork for most of my work. Was curious about the extra flexibility that your library provides
Check out this pre-print to see what happens in germ- granules : www.biorxiv.org/content/10.1...
"This helps explain how embryos develop without new transcription - with implications across species! Excited to hear your thoughts and welcome feedback from the community!
#Preprint #MolBio #SciComm 3/3"
"Using low-input ribosome profiling, we uncovered how cells control protein production in the first four cell divisions. Key finding: mRNA localization tightly links to translational efficiency, with OMA-1 emerging as a crucial player! 2/3"
