Pieter Dorrestein (@pieterdorrestein)

Yet another new function of bile acids -and relevance of the microbiome in regulating the efficacy of medications.
#microbiome #IBD. Discovered using #metabolomics repository scale analysis.
#opendata Thanks to all the collaborators and Vincent for leading it. www.biorxiv.org/content/10.6...

05.03.2026 04:13 👍 15 🔁 4 💬 0 📌 0

Not to mention 4Tb of results. We will need to buy some Inouye hardware to visualize :). We are going to have a lot of fun.

04.02.2026 19:59 👍 2 🔁 0 💬 0 📌 0

It only took 182242.7 CPU hours :). Only had to be done once and it will be a resource to mine for a long time. Can’t wait to see the results.

04.02.2026 19:57 👍 6 🔁 0 💬 1 📌 0

A wonderful day biking in Cyamaca and Anza Borrego just 45 min drive from San Diego.

01.02.2026 20:47 👍 12 🔁 0 💬 0 📌 0

Always so nice to come to @scrippsocean.bsky.social to be part of a thesis defense. Can’t wait to see the great science.

30.01.2026 19:53 👍 11 🔁 0 💬 0 📌 0

Today was the last day of the microbial metabolite keystone meeting. The posters and talks were beyond my wildest expectations. Safe travels to everyone that attended - thanks for making it a meeting to remember.

23.01.2026 05:53 👍 14 🔁 0 💬 0 📌 0

🎉 From beautiful Banff 🇨🇦❄️ Congrats to the Microbiome Metabolism & Metabolites / Human Microbiome awardees, thanks to @krfoundation.org!

@pieterdorrestein.bsky.social @mfgrp.bsky.social @gargneha.bsky.social @inesthiele.bsky.social @contaminatedsci.bsky.social #KSMicrobiome26 #KSMicroMetab26

22.01.2026 19:09 👍 20 🔁 3 💬 1 📌 1

12.12.2025 23:39 👍 5 🔁 0 💬 0 📌 0

The underappreciated diversity of bile acid modifications Using mass spectrometry-based tools to mine public untargeted MS/MS data revealed the vastly underappreciated diversity of bile acids hidden in plain sight and led to the discovery of previously unkno...

The best keychain ever - ty. This was a molecule discovered in this work www.cell.com/cell/fulltex... . To Prof. Ipsita - I can’t wait to see what you will discover in your own lab at Penn State. Such a pleasure to have had you as a co-worker in the lab. @ipsitamohanty.bsky.social

12.12.2025 23:38 👍 20 🔁 2 💬 1 📌 0

This is an important paper to read for people that are trying to understand metabolomics data. Ions detected (features) are not molecules and molecules will generate many ion forms. Be aware of MS ion forms - understand and leverage them. Dark metabolome has a lot of discovery potential.

07.12.2025 07:55 👍 22 🔁 8 💬 1 📌 0

Loving our local kitties.

07.12.2025 07:47 👍 4 🔁 0 💬 0 📌 0

Such amazing early clinical results from Enveda during my visit to Colorado. Seeing the elimination of lifelong health conditions in 6 weeks is humbling. Within three years to medications in ppl. Nature has done the drug discovery for us- we are just leveraging metabolomics data science to read it.

07.12.2025 07:46 👍 8 🔁 0 💬 0 📌 0

California in beautiful. Waking up to this view over thanksgiving break is amazing.

07.12.2025 07:39 👍 6 🔁 0 💬 0 📌 0

From the mountains to the beach. Such an amazing day today.

24.11.2025 01:19 👍 7 🔁 0 💬 0 📌 0

We are delighted to sponsor the Natural Products in the 'Omics Era' symposium at @pacifichem.bsky.social!

Keynote speakers include @pieterdorrestein.bsky.social whose research focuses on new MS-based methods to understand the chemistry of microbes #ORG018

📅19-20 December 2025
🔗pacifichem.org

19.11.2025 09:01 👍 10 🔁 3 💬 0 📌 1

Thanks to @NIDDK for supporting the collaborative microbial metabolite center and the training and yearly meeting it provides. A fun filled day on microbial metabolites.

13.11.2025 03:03 👍 19 🔁 0 💬 1 📌 0

It’s not even my birthday.

10.11.2025 20:23 👍 8 🔁 0 💬 0 📌 0

Riding local trails in the mist. So nice out.

09.11.2025 17:48 👍 7 🔁 0 💬 0 📌 0

Nice biking day in the San Diego mountains.

09.11.2025 04:08 👍 11 🔁 0 💬 0 📌 0

Congrats

01.11.2025 00:43 👍 1 🔁 0 💬 0 📌 0

Thanks for creating. It found a lot of things we addressed in a limitations section and also came up with comments that are erroneous in the literature. I wonder if you can build a module to have a dialogue on specific comments.

30.10.2025 23:26 👍 3 🔁 0 💬 1 📌 0

Nice mango harvest

30.10.2025 16:47 👍 12 🔁 0 💬 0 📌 0

Associate or Senior Editor (Nature Metabolism and Nature Communications) Job Title: Associate or Senior Editor (Nature Metabolism and Nature Communications) Location(s): New York, Jersey City, Philadelphia, Beijing or Shanghai Application Deadline: October 26th, 2025 About Springer Nature Springer Nature is one of the leading publishers of research in the world. We publish the largest number of journals and books and are a pioneer in open research. Through our leading brands, trusted for more than 180 years, we provide technology-enabled products, platforms and services that help researchers to uncover new ideas and share their discoveries, health professionals to stay at the forefront of medical science, and educators to advance learning. We are proud to be part of progress, working together with the communities we serve to share knowledge and bring greater understanding to the world. For more information, please visit about.springernature.com and @SpringerNature. About the Brand Nature Portfolio is a flagship portfolio of journals, products and services including Nature and the Nature-branded journals, dedicated to serving the scientific community. Visit nature.com and follow @Nature / @NaturePortfolio Nature Portfolio is a world leader in publishing high-quality research. The Nature Portfolio journals include Nature, the Nature Research journals, the Nature Reviews journals, Nature Communications as well as the Communications journals and NPJ series. Nature Communications is the leading Nature Portfolio fully open Open Access journal publishing high-quality scientific research across natural, clinical, social and applied sciences. About the Role Do you love science but feel that a career at the bench isn’t enough to satisfy your desire to learn more about scientific research? Do you enjoy reading papers outside your chosen area of research? If the answer is ‘yes’ to any or all these questions, you could be the person we’re looking for to join the Nature Portfolio editorial team! To help us build on the success of the portfolio, we’re seeking an editor with experience in metabolic disease research who has a critical eye, a deep understanding of their subject and interests beyond, and who can think on their feet. Knowledge of liver disease (MAFLD/MASH), lipid biology or immunometabolism is desirable, although we are open to applications from scientists working in any discipline covered by the journal. This is a permanent position within the Nature Portfolio. The successful candidate will primarily support Nature Metabolism but collaborate closely with the translational and clinical research team, and other teams, at Nature Communications. Please note that responsibilities and journal assignments may evolve over time in response to portfolio needs Nature Metabolism publishes high-quality papers in all areas of metabolic research and metabolic health - from fundamental cell biology to basic biomedical and translational research - providing a highly visible forum for communicating important advances to a broad readership. Role Responsibilities: Handling original research papers and working closely with editor teams on all aspects of the editorial process, including manuscript selection and overseeing peer review. Making well-reasoned editorial decisions on submitted manuscripts in the light of expert advice. Contributing to content and strategy in this area at Nature Metabolism and Nature Communications. Commissioning, editing content such as Reviews, or writing editorials. Liaising extensively with editors at other journals in the Nature Portfolio and with experts in the international scientific community. Attending conferences and visiting research institutions. Experience, Skills & Qualifications: A PhD (or equivalent) in a relevant research field covered by the journal Additional research experience is preferred but not required. A thorough understanding of recent trends and developments in the field is essential. A passion for science and a thirst to learn more. You must be able to demonstrate the breadth of your interest in scientific research, both within and beyond your speciality. The ability to read and assess the novelty, context and implications of research submitted to the journal from different areas of this discipline. Excellent communication and interpersonal skills, including fluent English (written and spoken). Be eager to travel and meet scientists worldwide, learn more about them and their research, and help them learn more about us and what we are looking for in the papers we seek to publish. Editorial experience is not required, although applicants with editorial experience are encouraged to apply and may be considered for Senior Editor positions. The successful candidates will report to the Chief Editor of Nature Metabolism. This demanding and intellectually stimulating role is in either of our offices in New York, New Jersey, Philadelphia, Shanghai or Beijing. We are open to applications from internal candidates from any of our offices. The position is offered on a permanent basis, and its starting date is envisaged as soon as possible. To Apply: Applicants should include a CV, a cover letter explaining their interest in the position, preferred office of employment, and a concise (300-400 words) discussion of recent developments or trends in the wider metabolism field, which you have found particularly exciting (and explaining why). Application Deadline: October 26th, 2025. Candidates will be considered as they apply. 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Springer Nature is an Equal Opportunity Employer that complies with the laws and regulations set forth in the following https://www.eeoc.gov/sites/default/files/2023-06/22-088_EEOC_KnowYourRights6.12ScreenRdr.pdf poster. At Springer Nature, we value the diversity of our teams and work to build an inclusive culture, where people are treated fairly and can bring their differences to work and thrive. We empower our colleagues and value their diverse perspectives as we strive to attract, nurture and develop the very best talent. Springer Nature was awarded Diversity Team of the Year at the 2022 British Diversity Awards. Find out more about our DEI work here: https://group.springernature.com/gp/group/taking-responsibility/diversity-equity-inclusion. If you have any access needs related to disability, neurodivergence or a chronic condition, please contact us so we can make all necessary accommodation. 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If you are interested in being an editor at Nature Metabolism and Nature Communications, apply below by Oct 26🧪

23.10.2025 16:12 👍 4 🔁 5 💬 0 📌 1

And does change daily within that neighborhood as more data is becoming available.

13.10.2025 17:02 👍 1 🔁 0 💬 1 📌 0

Yes 93.2%

13.10.2025 17:01 👍 1 🔁 0 💬 1 📌 0

They are super cute - they were chewing on the bark so they can eat the sap of the tree the next day. It was in a caatinga desert by a small town called Juatama.

06.10.2025 02:50 👍 2 🔁 0 💬 0 📌 0

What about this rodent? It’s the size of a big dog.

06.10.2025 02:29 👍 0 🔁 0 💬 1 📌 0

Yes do you see the 3 birds in the first pic?

06.10.2025 02:28 👍 1 🔁 0 💬 2 📌 0

06.10.2025 02:05 👍 6 🔁 0 💬 0 📌 0

06.10.2025 02:05 👍 6 🔁 0 💬 1 📌 0

Pieter Dorrestein

Latest posts by Pieter Dorrestein @pieterdorrestein