JoAnn Trejo

Here's the graphic for our Cell Reports paper!

Our surprising discovery "Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants" is published in Cell Reports! Led by Monica Gonzalez Ramirez, Lennis Orduna-Castillo & Prof. Irina Kufareva @ucsandiego.bsky.social
www.cell.com/cell-reports...

Our surprising discovery "Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants" is published in Cell Reports! Led by Monica Gonzalez Ramirez, Lennis Orduna-Castillo & Prof. Irina Kufareva @ucsandiego.bsky.social
www.cell.com/cell-reports...

Join us in #SanDiego for the ASCB | EMBO Meeting "Cell Bio 2026" from 12–15 December 2026. 🧪 #CellBio2026 is where the #CellBiology community gathers to share and discuss science, #network with peers and grow together as a field. Mark your calendars!

Model of PAR1, GRK5, beta-arrestin-2 and c-Src regulation by Caveolin-1

Our newest paper in J. Biol. Chem 10.1016/j.jbc.2026.111190
GPCR biased signaling is orchestrated by caveolae plasma membrane microdomains. Beyond its structural role, Caveolin-1 is regulated by Y-phosphorylation and protein-protein interactions allowing it to actively direct GPCR biased signaling.

Boost your grant funding success!! Now accepting applications for the UCSanDiego Health Sciences @ucsdhealthsci.bsky.social summer Grant Writing Course (GWC), proven success. Apps due March 17th, space is limited.

UNC Admin Can Now, Officially, Secretly Record Faculty The new policy prohibits students from recording class without permission but explicitly allows administrators to surveil professors for any “lawful purpose.”

www.insidehighered.com/news/faculty...

Gallego’s whole thing of moderating on policy, radicalizing on tactics/partisanship, and attacking when events allow is pretty clearly trying to find a way through the “popularism/populism/future of Dems” stuff.

Grant Writing Training Improves Funding Odds for Faculty Early career researchers improved their confidence in writing grants and increased their success in securing funding after an intensive course on the subject.

A tiny bit of news, amid the rise of authoritarianism! A report about our study on grant writing of @ucsandiego.bsky.social by @TheScientist - outcomes for participants in receiving R01 or R01-equivalent awards >NIH national average for first time submitters.

www.the-scientist.com/grant-writin...

Are You AWARE
ICE AGENTS ARE INCOMPETENT
ICE AGENTS ARE NOT TRAINED
Accelerated RECRUITMENT
Artificial Intelligence tool used by ICE incorrectly passes on resumes as law enforcement
IMPROPER DEPLOYMENT NO 8 WEEK TRAINED

"GRAVY SEALS"

Call Your Senators
No funding ICE
202 224-3121
ICE OUT

he main phone number for the U.S. Congressional Switchboard, a central point to reach Senators and Representatives, is (202) 224-3121, allowing you to connect with your elected officials to discuss issues, find their offices, or get general Capitol Hill information. You can also find direct contact information and legislative details on official sites like House.gov and Congress.gov to communicate with your specific Representative or Senator about bills and concerns

No science or nature today. ICE just murdered another person in my home state, an ICU nurse working with vets & now they're trying to frame him for the action . All because ICE is angry & afraid of the 50000 Minnesotans who marched yesterday. If you're not calling Congress you're letting them down

My personal guiding principle has always been "agree where you can and fight where you must." And I believe this is a time when we must fight back.

TODAY, Friday January 23rd, 2026:

We are ALL residents of Minnesota.

We ALL want #ICE_OutForGOOD 🚫 🧊

Also: #ICE_OUT4ReneeGood 💔

Covers of the 2 leading science journals this week
@science.org and @nature.com
www.science.org/content/arti... www.nature.com/immersive/d4...

Today..

Excellent work by the Eric Camerer group!

@petebuttigieg.bsky.social: "We have an ICE agent who should have been trained not to be in front of a vehicle and never to shoot into a moving vehicle, and yet this happened on [Kristi Noem's] watch. The whole POINT of Homeland Security is to make this country more stable and safe."

“God damn them all.”

If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.

IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.

Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.

January 6th United States Capitol riots. Let's not forget!

Opioid receptor agonists take advantage of new understanding of GPCR biology Tool compounds separate pain relief from breathing suppression in mice

Researchers recently announced an advance in pharmacologists’ long-term goal to make a compound that could preserve the pain relief but ditch the undesirable side effects. cen.acs.org/biological-c... #chemsky 🧪

2025 has been one hell of a year! Take some time to enjoy the holidays, spend time outdoors, strengthen family ties and friendships, relax and reset for next year. Happy Holidays to you and yours!

This about sums it up, folks.
www.thelancet.com/journals/lan...

R35 MIRA NOFO

NIGMS R35 Maximizing Investigator's Research Award (MIRA) for Outstanding Investigators new NOFO is available!!
Submission dates starting in January 2026 through May 2028.
See link below: simpler.grants.gov/opportunity/...

Breaking: Georgia Democrats flip conservative seat in yet another upset That's 25 pickups for Democrats nationwide this year—and zero for Republicans

BREAKING: Democrats have flipped a conservative state House seat in Georgia in yet another upset.

It's a 14-point overperformance *and* the 25th legislative flip of the year for Dems. Republicans? Zero.

Read our complete writeup here -->

Early Career Faculty Opportunity! @ucsdhealthsci.bsky.social Health Sciences Summer Institutes in Infectious Diseases - opportunity to work with mentors on enhancing research development and grant writing skills!

Early Career Faculty Opportunity! @ucsandiego.bsky.social Health Sciences Summer Institutes (SI) in Cardiovascular Sciences, engaged with outstanding mentors to enhance research development and grant writing skills!

Submit your work to MBoC!

Submit your work to MBoC! The flagship journal of @ascbiology.bsky.social, driven & powered by scientists, dedicated to advancing scientific discovery. Why? 1) peer reviewed by scientists like you, 2) fast turnaround and 3) high visibility >2.5 million views & downloads, 4) high acceptance rate: 43%

‼️The Importance of #DiversityEquityInclusion to science by @needhibhalla.bsky.social @joann-trejo.bsky.social @marymunson4.bsky.social in @natcellbio.nature.com:
“diversity in the scientific workforce increases creativity and success in tackling challenging problems.”
Link for free: rdcu.be/eSPGH