Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.26.701803v1
27.01.2026 22:15
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Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.26.701803v1
Preprint alert: Check out our latest work 'Electro-Calcium Uncoupling in Capillary Endothelial Cells Precedes Neurodegeneration in Alzheimer's disease'. We used Young 5xFAD mice to decipher neurovascular communication deficits in pre-symptomatic phase of AD.
www.biorxiv.org/content/10.6...
Thanks @sorengrubb.bsky.social for creating this 🧵 to summarize the findings. Thanks @alleninstitute.org @hhmijanelia.bsky.social and @helenelab.bsky.social for the EM datasets.
#EM #Cilia #brainvasculature
First Preprint from my group @NIHIRP, where a summer project led by Vanshika Chaddha took unexpected turn into identifying Primary Cilia across the Brain Vasculature.
New avenues for NVC.
Amazing Collaboration with @sorengrubb.bsky.social, Carolyn Ott and Jennifer Lippincott-Schwartz.
Join us in congratulating the CCAD Cohort of 2026! We look forward to their innovative contributions to the field of Alzheimer’s disease and the CCAD community.
#CCAD2026 #AlzheimersDisease #NewVisionResearch
Excited to share our first pre-print from the new SSPB section at the NIDCD!🥳
We hope you find it interesting and inspiring for future research. Thanks to our team, colleagues, mentors and collaborators 🔥 💪 🙏 .
Take a look—and stay tuned for more!
www.biorxiv.org/content/10.1...
Showing how a precapillary sphincter dilates during high blood pressure
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
Congrats @sorengrubb.bsky.social and team :)
Congrats John and team :)
Congrats :)
Congratulations 🎊
Congratulations to you and your team 🎊
I am actively looking for a research scientist position or research administration role within the Raleigh-Durham (RDU) area! Please reach out if my background and skillset might fit your labs needs :-) Lots of experience with preclinical models, translational neuroscience, and behavioral analyses!
Check out this editorial written for a beautiful work by MArk Nelson's Lab on electro-calcium coupling and control of the neurovascular unit.
www.pnas.org/doi/10.1073/...
Congratulations 🎊
Thank you, highly appreciate it :)
Check our illustration of the Electro-Calcium Coupling
New publication Alert: Delighted to share our latest work. We describe a unique relationship between electrical and Calcium signaling; 'Electro-Calcium Coupling' in brain capillary endothelial cells.
www.pnas.org/doi/10.1073/...
Congratulations 🎊
Congratulations 🎊
Yes, please. Thank you 😊
I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.
Congratulations :)
Join us!!
We are looking for a postdoc candidate to join our team. We study neurovascular coupling mechanisms in the basic physiology and in the models of Vascular Dementia. Learn more: research.ninds.nih.gov/mughal-lab
#Postdocjobs #Neurovascular #Physiology
Thank you for the repost/share :)
Please add me. Thanks :)
Yes, please
Please add me :)
Congratulations 🙂
I am a Stadtman Tenure-Track Investigator at the NIH-IRP (NINDS-Stroke Branch + NHLBI-TVM). I lead 'Neurovascular Research Unit' and we study blood flow regulation in the brain & clearance of metabolic by-products in the health and mouse models of VCID. Learn more: research.ninds.nih.gov/mughal-lab
