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Amritesh Sarkar

@amritesh-iisc

PhDing @IIScBangalore; affiliated to @SrimontaGayen. Interests: epigenetics, embryonic development, XCI-XCU, omics

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07.11.2025
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Latest posts by Amritesh Sarkar @amritesh-iisc

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Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

New @nature.com
The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills
nature.com/articles/s41...

25.02.2026 16:02 πŸ‘ 203 πŸ” 52 πŸ’¬ 2 πŸ“Œ 2
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Human eggs must segregate their chromosomes with exquisite precision β€” yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)

12.01.2026 11:22 πŸ‘ 27 πŸ” 15 πŸ’¬ 1 πŸ“Œ 3

Congratulations!

08.01.2026 10:31 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Read in Nature: nature.com/articles/s41586-025-09899-8

Read in Nature: nature.com/articles/s41586-025-09899-8

Stress controls epigenetic inheritance!

A histone ubiquitylation-basedΒ regulatory hub links stress/environmental signaling to heterochromatin self-propagationΒ and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
πŸ‘‰ nature.com/articles/s41586-025-09899-8

07.01.2026 16:46 πŸ‘ 35 πŸ” 22 πŸ’¬ 3 πŸ“Œ 4
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Epigenetics Update - Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation bit.ly/4aPlECl

#Epigenetics #SingleCell #Multiomics #Gonads
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Empower your research with high-res epigenetic insights at epigenometech.com

07.01.2026 08:38 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are πŸ”₯ πŸ‘‡

"Single-cell map of the female brain across reproductive transitions"

www.biorxiv.org/content/10.6...

04.01.2026 20:45 πŸ‘ 139 πŸ” 60 πŸ’¬ 8 πŸ“Œ 2
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Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com πŸŽ‰πŸŽ‰πŸŽ‰
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

15.12.2025 16:22 πŸ‘ 72 πŸ” 31 πŸ’¬ 6 πŸ“Œ 2

Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org

15.12.2025 06:57 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Congratulations Vincent and team!

26.11.2025 16:51 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Thrilled to share that @Avinchal from our lab presented her work on effect of heat-humidity stress on fetal development and #epigenetic regulation in the recent #GordonConference on "Epigenetic Variation: Mechanisms and Impact across Systems" #ClimateChange #GlobalWarming #MaternalChildHealth

21.11.2025 13:00 πŸ‘ 1 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0