The Lancet Primary Care

🎧 Listen to the latest episode of The Lancet Primary Care in conversation with.... where we discuss the PRUDENCE trial with three of its lead authors

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🆕In a linked Comment, Andreas Plate and Oliver Senn contextualise the findings of the two PRUDENCE Articles, and provide an overall perspective for future stewardship efforts

Read the Comment here ➡️ www.thelancet.com/journals/lan...

The Research in context panel from the Article presenting the primary trial results, providing background for the research, the added value of the study, and implications of all the available evidence

🆕 The PRUDENCE investigators report their multicounty RCT of a point-of-care testing strategy to aid antibiotic prescribing for respiratory tract infections, and the embedded qualitative process evaluation

Read the trial results bit.ly/4lgz0uy
Read the embedded process evaluation bit.ly/40c9SLM

“The findings from the trial and its process evaluation highlight the complexity of implementing point-of-care testing in routine care and the need for complementary strategies to more effectively address the multiple clinical and non-clinical drivers of antibiotic overprescribing”...

Quote card reading: “We would like to share our baseline data on the community we have built over this first year of activity and announce our commitments to equity, diversity, and inclusion as a journal.” Yaiza del Pozo Martín; The Lancet Primary Care

🆕 The Editor in Chief of The Lancet Primary Care reports the baseline data for our peer-review and authorship community over the first 6 months of the journal, and details our ambitions and commitments to equity, diversity and inclusion.

Read the Comment now ➡️ www.thelancet.com/journals/lan...

Defining recurrent urinary tract infections and quantifying bladder cancer risk in primary care in England: a nationwide case–control study Our data suggest that recurrent UTIs within 6 months were a strong signal of bladder cancer risk. Our findings can help to refine existing guideline recommendations for patients with recurrent UTIs wh...

... 🆕 In their Article, Sikhuphukile G Mahati and colleagues aimed to better define and quantify the effect of recurrent urinary tract infections on the likelihood of #bladdercancer

Read the full Article ➡️ www.thelancet.com/journals/lan...
@jianhuawu6.bsky.social
#UTI #primarycare #medsky

Figure 2 from the article, showing four panels, labelled A to D, with the unadjusted and adjusted odds ratios for bladder cancer by frequency of UTI during a 5-year period. Panel A shows unadjusted odds ratios. Panel B shows odds ratios adjusted for sociodemographic factors including ethnicity and Index of Multiple Deprivation. Panel C shows odds ratios adjusted for clinical risk factors including BMI, smoking status, and comorbidities. And panel D shows fully adjusted odds ratios for sociodemographic and clinical risk factors.

🆕 “Our study provides evidence to refine current clinical definitions of recurrent UTIs in patients with bladder cancer, which can improve clinical recommendations and pathways aiming to identify and investigate patients at risk of bladder cancer.”
...

@katiecharlwood.bsky.social
@drjessicawatson.bsky.social

Figure 1 from Review, showing a grid describing tests to monitor disease progression and treatment response—answers to filtering questions. The green colour coding in the figure indicates evidence and consensus to include tests for routine monitoring of individuals with CKD stage G3, and red colour indicates evidence and consensus to exclude tests.

🆕In their Review, Martha Elwenspoek describe their rapid review, routine data analysis, and consensus study to develop evidence-based testing panels for adults with #CKD stage G3 in #primarycare

Read the full Review here ➡️ www.thelancet.com/journals/lan...

Our March 2026 issue is live!

Including research in individuals at risk of developing arthritis, real-world data on anifrolumab in #SLE, #cardiovascular risk in #APS, and childhood-onset Sjögren's disease, plus much more! thelancet.com/journals/lan... #Rheumsky

Cover by @emma-cheng.bsky.social

Photograph of a female doctor talking to a patient. Image credit: Siri Stafford

🆕 In their Comment, Erin K Ferenchick and colleagues highlight the importance of family doctors to the integration of mental health care in primary care

Read the Comment here www.thelancet.com/journals/lan...

Image credit: Siri Stafford

Frailty, polypharmacy, and the case for pragmatic prescribing in primary care Primary care clinicians are often caught between conflicting recommendations for clinical care. On one side, specialist guidelines and trial evidence urge intensive treatment, such as tight blood pres...

🆕 In their Comment, Peter Hanlon and colleagues discuss pragmatic prescribing for people with moderate or severe frailty in primary care
Read the full Comment here ➡️ www.thelancet.com/journals/lan...

Corporatisation of primary care: the need for critical analysis Across primary care, corporate actors are gaining influence,1,2 which reflects a broad corporatisation of health care: “the general trend throughout the healthcare industry towards higher levels of in...

... 🆕 In their Comment, Lisa Jansen and colleagues discuss the potential impacts of the corporatisation of primary care

Read the full Comment here ➡️ www.thelancet.com/journals/lan...

Corporatisation of primary care: the need for critical analysis Across primary care, corporate actors are gaining influence,1,2 which reflects a broad corporatisation of health care: “the general trend throughout the healthcare industry towards higher levels of in...

🆕“Making a profit in primary care services is not problematic in itself; however, the practice becomes concerning when maximising profits is prioritised over providing high-quality and accessible health-care services grounded in the core values and characteristics of primary care” ...

✨ICYMI
Submit your manuscript before June 30,2026, and we’ll reduce your APC by 50% if accepted!
To save you time, discover what’s needed for submission and access the manuscript submission system here ➡️ hubs.li/Q03z-hC_0
#medsky #familymedicinesky #internalmedicinesky #primarycare

The cover of The Lancet Primary Care January 2026 issue, featuring the image of an older white man, talking to a female doctor who has her back to the camera, and she has her hand on his shoulder in a comforting motion. the man is smiling.

Our first issue of 2026 is now live! 🎉

As a gold #openaccess journal, our content is free to read by everyone, always.
Explore and download the issue on our journal homepage: www.thelancet.com/journals/lan...

#familymedicine #communitycare #primaryhealthcare #primarycare

Alt text: Card reads ““We know peer review is crucial to our journal's success and we would like to extend our heartfelt gratitude to each one of you who provided valuable feedback to authors — The Lancet Primary Care”

🆕 Our first annual thanks and public recognition of all those who have reviewed for us in 2025 is now available
➡️ www.thelancet.com/journals/lan...

🎧 In the latest episode of The Lancet Primary Care in conversation with... we talk to investigators from the Virus Watch Community cohort and a former GP with #longCOVID

Listen now ➡️
🍏 podcasts.apple.com/us/podcast/t...
🎵 open.spotify.com/show/5gsbXDd...
⚡ thelancetprimarycare.buzzsprout.com

Clinical pathways before total knee replacement in England: a population-based retrospective cohort study using sequence analysis and multilinked electronic health records The identification of distinct and non-guideline-concordant pathways highlights persistent gaps in primary care management of patients with osteoarthritis. These findings underscore the need for targe...

...🆕 Smitha Mathew and colleagues report on clinical pathways experiences by patients before total knee replacement in England

Read the full Article ➡️ www.thelancet.com/journals/lan...

Clinical pathways before total knee replacement in England: a population-based retrospective cohort study using sequence analysis and multilinked electronic health records The identification of distinct and non-guideline-concordant pathways highlights persistent gaps in primary care management of patients with osteoarthritis. These findings underscore the need for targe...

🆕“The identification of distinct and non-guideline-concordant pathways highlights persistent gaps in primary care management of patients with osteoarthritis. These findings underscore the need for targeted primary care interventions to support... care before knee replacement.”
...

Multiplex PCR testing for Treponema pallidum and herpes simplex virus in primary care to detect primary syphilis in Victoria, Australia: a prospective cohort study Multiplex PCR testing for syphilis and herpes among patients for whom HSV PCR alone was ordered improved detection of primary syphilis in primary care. More widespread implementation would reduce misd...

... 🆕Rebecca Wigan and colleagues report the results of their prospective cohort study investigating use of multiplex PCR testing for T Palladium and HSV for the detection of primary syphilis in primary care in Victoria, Australia.

Read the full Article➡️ www.thelancet.com/journals/lan...

🆕 “Syphilis has re-emerged as an important public health problem globally... Primary care is important in improving early syphilis detection and control, particularly in settings where access to specialist sexual health services is scarce.”
...

Safeguarding planetary health: the contribution of community health workers to climate stability, global equity, and social justice Planetary health, the interdependence of human health and natural systems, is under severe threat. Climate breakdown, biodiversity loss, and chemical pollution are driving overlapping crises that alre...

🆕 “In this Viewpoint, we argue that trusted, hyperlocal, and globally present CHWs are a largely overlooked workforce in tackling the climate crisis, despite already doing work in adapting to and mitigating climate change.”

Read the full Viewpoint now ➡️ www.thelancet.com/journals/lan...

Post-COVID-19 condition and disparities in daily functional activities in England: a retrospective analysis of data from the Virus Watch community cohort Socioeconomic deprivation, rather than migration status or ethnicity, primarily drives functional limitations within this cohort of individuals with post-COVID-19 condition. Functional limitations mig...

... 🆕Wing Lam Erica Fong and colleagues investigate disparities in daily functional activities in people with post-COVID-19 condition (#longCOVID) in their retrospective analysis of the Virus Watch Community cohort

Read the full Article ➡️ www.thelancet.com/journals/lan...

Post-COVID-19 condition and disparities in daily functional activities in England: a retrospective analysis of data from the Virus Watch community cohort Socioeconomic deprivation, rather than migration status or ethnicity, primarily drives functional limitations within this cohort of individuals with post-COVID-19 condition. Functional limitations mig...

🆕“Socioeconomic deprivation, rather than migration status or ethnicity, primarily drives functional
limitations within this cohort of individuals with post-COVID-19 condition” ...

Promotional card for the Lancet Commission on a citizen-centred health system for India. Background image is of a community meeting at a Health and Wellness Centre in Nazardih village, Nawada, district, Bihar. Copyright: Population Foundation of India

India stands at a pivotal moment in its journey towards universal health coverage ⚖️

A new Lancet Commission calls for a citizen-centred approach to transform India’s health system & ensure equitable, high-quality care for all: spkl.io/63327AUHbc

Managing mental health problems after mild traumatic brain injury: a clinical priority A few years ago, I was involved in a car–bicycle accident. I went headfirst into the wing of the car, denting the car’s metalwork and fracturing my seventh cervical vertebra. I briefly lost consciousn...

🆕In a linked Comment, Christopher Dowrick discusses future directions in light of the study findings:
“The key message from this study is that simply offering information is not enough; there is a need for action.”

Read the full Comment ➡️ www.thelancet.com/journals/lan...

Effectiveness of a guideline implementation tool for supporting management of mental health complications after mild traumatic brain injury versus usual care in primary care: a triple-blind, cluster-r... The guideline implementation tool designed for proactive management of mental health complications after mild traumatic brain injury did not result in clinically meaningful reductions in the risk of m...

...🆕Ana Mikolić and colleagues report their cluster randomised controlled trial investigating the effectiveness of a guideline implementation tool to support the management of mental health complications after mild traumatic brain injury
Read the Article here ➡️ www.thelancet.com/journals/lan...

🆕“Our findings reinforce the importance of monitoring for mental health complications after mild traumatic brain injury. Our assessment of mechanistic variables...can help inform future research on implementation interventions that aim to close the evidence-practice gap”
...

The case for community health workers in high-income countries Health systems in high-income countries (HICs) face multiple complex challenges, including ageing populations, multimorbidity, workforce shortages, and increasing health-care costs. Some of these chal...

🆕 ...In their Viewpoint, Azeb Gebresilassie Tesema and colleagues discuss the need for integrated community health worker programmes in high-income countries
Read the full Viewpoint➡️https://www.thelancet.com/journals/lanprc/article/PIIS3050-5143(25)00068-8/fulltext