rEView

Missing #ISEV2025 this year?
Never fear!
The #rEViewPodcast has plenty of #ExtracellularVesicles content to keep your fomo at bay - and we hit a major milestone!
250 plays on Spotify and counting… 🥳🙌

open.spotify.com/show/5Mio0bU...

youtube.com/@the_review_...

S02 E02 (Feb 2025): The rEView Podcast - Farouq Sharifpour YouTube video by rEView

The next #rEViewpodcast is live!
This episode we talk to Farouq Sharifpour @jcu about his research on all things Helminths 🪱 and Spirulina, including his latest 2 publications in JEV and JEx Bio.

youtu.be/XjvH1c2payQ?...

open.spotify.com/episode/3rWQ...

#extracellularvesicles #exosomes @isev.org

S02 E01 (Jan 2025): The rEView Podcast - Alice Gualerzi with Caterina Piunti The rEView Podcast · Episode

Also on Spotify:

open.spotify.com/episode/5EjX...

#extracellularvesicles #exosomes #science #research #STEM #podcast #scicomm

S02 E01 (Jan 2025): The rEView Podcast - Alice Gualerzi with Caterina Piunti The rEView Podcast · Episode

Excited to announce the beginning of Season 2 of the rEView podcast! 🙌

Caterina Piunti talks to Alice Gualerzi, a Senior Researcher at LABION. Her research focuses on characterization of #extracellularvesicles for use in diagnostics and regenerative medicine.

youtu.be/QqJv_PnOz60?...

Conclusion:
Conjugating stem cell-derived EVs to dopamine enhances their uptake in the brain without side-effects and provides neuroprotective effects against Parkinson’s disease.

Future research could use similar approaches for other disorders such as Alzheimer’s disease.

Key findings:
-Dopa-EVs significantly enhanced uptake of EVs in the brain (in vivo) and in vitro
-Dopa-EVs provided neuroprotective effects against Parkinson’s disease in vivo and in vitro

Key methods:
-Tangential flow filtration to isolate EVs
-click-chemistry to conjugate them to dopamine (dopa-EVs)
-Characterized EVs by electron microscopy, Western blotting and nanoparticle tracking
-Tested the effects of dopamine-conjugated EVs using both in vitro and in vivo models

Dopamine‐conjugated extracellular vesicles induce autophagy in Parkinson's disease The application of extracellular vesicles (EVs) as vehicles for anti-Parkinson's agents represents a significant advance, yet their clinical translation is hampered by challenges in efficient brain d...

It's #rEView Wednesday! Here’s a new article published in #JEV revealing that adipose-derived stem cell dopamine-conjugated #extracellularvesicles are brain-targeting and induce neuroprotective effects in Parkinson’s disease.

isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

Engineered extracellular vesicles as a next-generation vaccine platform EV vaccines can be engineered to be loaded with antigenic proteins and antigen-encoding RNAs by genetic engineering of parental cells or direct engineering of EVs. Due to possessing many of the key immunostimulatory properties of donor cells, EVs are capable of activating immune responses for vaccination against infectious diseases and cancers by direct antigen-presentation, semi-direct antigen-presentation, and indirect antigen-presentation pathways.

Engineered extracellular vesicles (EVs) are emerging as next-gen vaccines.

Safe and efficient, they target cancers and infectious diseases by delivering antigens and boosting immune response.

A promising leap in vaccine technology.

www.cell.com/matter/abstr...