Marco Trujillo

STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation - The EMBO Journal Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...

Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation
link.springer.com/article/10.1...

Check out the latest issue of Biochemical Society Transactions, featuring reviews on translation initiation, intracellular proteasome shuttling and non-enzymatic roles of chromatin modifiers 🧪 https://ow.ly/ysfQ50YgbXn

Excited to share our latest study in Nature Communications ✨

We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track.

Paper: www.nature.com/articles/s41...

#Genomics #DNADamage #CellBiology

Plants use cell-surface and intracellular receptors that collaborate to detect pathogens🦠. We discovered that a key #ubiquitin recognition event recruits both receptor types into an unexpected dual receptor complex that boost the translation of defence proteins and establishes robust #PlantImmunity👇🏾

The proteasome organization into fibers and other supramolecular arrangements contributes to its regulation #yeast

sciencedirect.com/science/arti...

#TeamTomo visualizes amazing (green 💚♻️) proteasome crystals in yeast. This project was a long time coming -- I remember talking to Cordula about it back when I was a postdoc in Martinsried. Some really cool and surprising findings here. Nice to see it out, and congrats to all the authors! 🧪 🔬

Figure 1. Scheme of split intein-mediated protein editing

Programmable protein editing by split intein-mediated recombination by Takumi Yanase and team: www.biorxiv.org/content/10.6...

Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026

Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...

New Article: "ATG5–HSP90.2-mediated micromitophagy as a cytological basis for maternal inheritance of plant mitochondria" rdcu.be/eZ87l

Micromitophagy in male germline cells underpins paternal mitochondrial elimination and supports the zygote-to-embryo transition.

Thrilled to congratulate the newly minted Dr. Allahham on an outstanding viva! Many thanks to collaborators and the examiners for their invaluable support throughout the process.
@ottlab.bsky.social @kleinevehnlab.bsky.social @hartman-plantlab.com

A CK2-FBXW11 kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating Tryptophan 2,3-dioxygenase stability Small molecules toggling the ubiquitin-proteasome system (UPS) are powerful regulators of protein degradation. Yet, mechanistic knowledge of how endogenous ligands gate UPS decisions remains rudimenta...

The Schulman Lab uncovered an endogenous small molecule allosterically stabilizing its own metabolizing enzyme through protection from a phosphorylation-ubiquitination cascade
www.biorxiv.org/content/10.6...

Merry christmas to the Freiburg bunch from the North!🎄

...and Isono Lab (Konstanz)!!

New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)

#ArtAdventCalendar Day 5

Ubiquitin - Spraypaint on conrete

Rewriting the code of plant immunity go.nature.com/475WgV7

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation | The EMBO Journal imageimageFibril formation of α-synuclein is central to Parkinson’s disease (PD) pathology. This study shows that UBQLN2 droplets catalyze α-synuclein fibrillization via their liquid-gel/solid transition, while a small molecule targeting UBQLN2 ...

Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!

www.embopress.org/doi/full/10....

Thanks so much Caro! Excited to be here!

Thank you so much Marco!

Thank you Thorsten!

Grazie Marco!

Thank you so much Andreas! It is indeed!

Thanks!

Hey Sjon, thanks! Now it will be more difficult to drop by though ;)

Hey Tim, thanks a lot! Looking forward to insider tips 😉

Excited to join the Nordinfect meeting on #infection #inflamation and #immunology. Great chance to meet the community #NDI3
@fzborstel.bsky.social

ndi3.fz-borstel.de?trk=public_p...

Thank you Greg!

Thanks so much Yasi!

Thank you Freddie!