Akshay Vishwanatha

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Publication alert! 🔔 Our recent work exploring how Plasmodium uses a Rad51 independent homologous recombination to diversify its var gene repertoire is now published in 🧬 Nucleic Acids Research! @oupprimary.bsky.social @narjournal.bsky.social Read more here.
tinyurl.com/794brb6h

Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification The haploid malaria parasite, Plasmodium falciparum, evolved a unique cohort of DNA repair pathways enabling the parasite to survive in a vertebrate host red blood cell and the mosquito vector. P. fal...

Wondered how malaria parasites are able to evade human immune system by increasing the number of virulence genes? Read our preprint! We show how deficiencies in DNA repair mechanisms specific to core genome and subtelomeric regions enable parasites to achieve this.
www.biorxiv.org/content/10.1...