Nimesh Chahare's Avatar

Nimesh Chahare

@onenimesa

Doing #EpithelialMechanics! with chick embryo 🐣 Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona nchahare.github.io

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15.11.2024
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Latest posts by Nimesh Chahare @onenimesa

Check out my contribution to the wonderful threads posted by @epimechfc.bsky.social !!

In this one I talk about #3DTFM!

πŸ‘‡

02.03.2026 10:33 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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We had covered the history of traction force microscopy (TFM) earlier:
bsky.app/profile/epim...

But what about applying TFM into more physiologically relevant systems, such as those in 3D?

I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

01.03.2026 07:58 πŸ‘ 22 πŸ” 11 πŸ’¬ 1 πŸ“Œ 2

Tissue mechanics and synth morphogenesis folks, bump on this:
Would you or someone in your lab be up for a video of a protocol you use getting recorded? The tips and tricks, the hard-to-explain-without-seeing-it-done?

In the name of standardization and reproducibility in the field: get in touch! πŸ«€

24.02.2026 15:31 πŸ‘ 6 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

Beautiful thread😍 about Flipper from @juanmagararc.bsky.social #EpithelialMechanics

08.02.2026 16:29 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social πŸ‘‹ I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.

Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!

08.02.2026 07:59 πŸ‘ 80 πŸ” 26 πŸ’¬ 3 πŸ“Œ 4

Epithelial Mechanics Fan Club @epimechfc.bsky.social is top-fin #scicomm, in case you haven't heard of it!

Follow them for more like this thread posted by Knaut Lab member and #zebrafish lateral line guru, @weiyiqian.bsky.social 🐟

20.01.2026 09:52 πŸ‘ 12 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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PhD job alert! 🚨Interested in epithelial mechanics and bacterial infection? Do you have a computational background? Don’t miss this opportunity!

Details in thread πŸ§΅πŸ‘‡

#AcademicJobs #PhDPosition #Biomechanics
Please RT πŸ”¬πŸ’» @epimechfc.bsky.social @unizar.es @i3a.unizar.es @esbiomech.bsky.social

23.01.2026 12:13 πŸ‘ 6 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0
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How can structures at the vertex of 3 cells have effects at the tissue level?

Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧡‡️ doi.org/10.1126/scie...

18.01.2026 14:07 πŸ‘ 68 πŸ” 23 πŸ’¬ 1 πŸ“Œ 5
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Lobbying in Albany with @uaw.org and @cpw-uaw4100.bsky.social for the Empire Biomedical Research Institute. Learn more:
@fundnyscience.bsky.social.

13.01.2026 18:42 πŸ‘ 12 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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How does a uniform zygote reliably break symmetry?
How do initially identical cells diverge in cell-cycle timing and transcriptional state?

In our new paper in Nature Physics, we show that embryo geometry itself is sufficient to pattern early development.

www.nature.com/articles/s41...

12.01.2026 22:00 πŸ‘ 16 πŸ” 4 πŸ’¬ 2 πŸ“Œ 3
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How can embryos use pulsatile contraction to shape tissue development during morphogenesis? I'm @weiyiqian.bsky.social and with this thread I want to introduce the roles of pulsatile actomyosin in animal development and the mechanisms that drive actomyosin to pulse

10.01.2026 20:01 πŸ‘ 38 πŸ” 11 πŸ’¬ 1 πŸ“Œ 2

Very nice new preprint from the lab!
Congrats @yuieda1.bsky.social @jeromegros.bsky.social

09.01.2026 12:11 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids - Nature Cell Biology Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.

Congratulations to Byung Ho from the @anne-grapin.bsky.social lab @mpi-cbg.de and the rest of the team to this fantastic publication: www.nature.com/articles/s41...

07.01.2026 13:43 πŸ‘ 22 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? πŸ€”

We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.

buff.ly/w56OUJT

05.01.2026 08:00 πŸ‘ 64 πŸ” 20 πŸ’¬ 1 πŸ“Œ 0

Tissue mechanics and synth morphogenesis folks!
Would you or someone in your lab be up for recording a video of a protocol you use? Something hard to explain without seeing it done?

In the limbo hours πŸŒ€ between today and 2026🌟, if something comes to mind -get in touch!
#JoVE organizes the filming 🀳

30.12.2025 19:46 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Beads moving around in the lumen of a developing lung, taken my first month of my postdoc when I was playing around with how I could make different viscoelastic material measurments.

17.12.2025 14:16 πŸ‘ 6 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some πŸ”₯ new results in here since the biorvix incl (1) a new RARE-GFP reporter βœ³οΈπŸ™Œ, (2) additional NMP quantification πŸ”’, (3) no neural tube patterning on RA inhibition πŸ™… etc. Enjoy! 😍 www.nature.com/articles/s41...

16.12.2025 10:04 πŸ‘ 87 πŸ” 33 πŸ’¬ 5 πŸ“Œ 0
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For this festive season, I’m sending friends and family something a little different: postcards straight from the microscope. πŸ”¬

Featuring my hiPSC Christmas tree from last year and a hiPSC colony turned into a festive bauble, with wishes for a season that’s festive at every scale. πŸŽ„

16.12.2025 15:12 πŸ‘ 18 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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I am putting together a collection of video-protocols we (will) use in tissue mechanics researchπŸŒ€
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech

16.12.2025 14:28 πŸ‘ 31 πŸ” 8 πŸ’¬ 1 πŸ“Œ 3
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Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses?

🧡 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!

14.12.2025 08:08 πŸ‘ 73 πŸ” 30 πŸ’¬ 1 πŸ“Œ 2
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Epithelial Mechanics Fan Club - FocalPlane Epithelial Mechanics Fan Club - News

Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...

05.12.2025 13:35 πŸ‘ 15 πŸ” 10 πŸ’¬ 0 πŸ“Œ 2
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It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

23.11.2025 08:01 πŸ‘ 50 πŸ” 19 πŸ’¬ 1 πŸ“Œ 3

Exciting News! πŸ₯³ Our Epithelial Mechanics Fan Club website is now live! πŸŽ‰
πŸ‘‰ epithelialmechanics.github.io

Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!

23.10.2025 07:21 πŸ‘ 43 πŸ” 14 πŸ’¬ 1 πŸ“Œ 1

Join the coolest club on the internet!
#EpithelialMechanics

23.10.2025 15:11 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Epithelial Mechanics Fan Club

πŸŽ‰πŸŽ‰ We finally have a website! πŸŽ‰πŸŽ‰

Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io

Huge thanks to all thread-contributors and to you for following us!

23.10.2025 07:00 πŸ‘ 40 πŸ” 17 πŸ’¬ 0 πŸ“Œ 3
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πŸ“£Announcing the 4th edition of the EMBL‑IBEC Conference on β€œEngineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...

22.10.2025 14:04 πŸ‘ 66 πŸ” 41 πŸ’¬ 0 πŸ“Œ 2
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1/ πŸ£βš’οΈ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!

12.10.2025 12:51 πŸ‘ 27 πŸ” 10 πŸ’¬ 1 πŸ“Œ 1

Congratulations Isabela πŸŽ‰ πŸŽ‰

30.09.2025 02:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Happy to share that my PhD has finally taken the shape of a paper! ✨

Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.

πŸ§΅πŸ‘‡

27.09.2025 12:01 πŸ‘ 43 πŸ” 12 πŸ’¬ 3 πŸ“Œ 0
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Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧡 πŸ‘‡

29.09.2025 16:44 πŸ‘ 173 πŸ” 74 πŸ’¬ 10 πŸ“Œ 2