Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging 💫.
Thanks, Wanlu and all the collaborators!
🔬🧬 New in @natcomms.nature.com: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess
www.nature.com/articles/s41...
@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution
Thanks Aleksander, also for your paper link!
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
Thank you very much, Takashi!
Check out Andi's #Bluetorial for a summary of our findings 🙌
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
My first own project is published:
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Our excellent postdoc Wanlu Zhang is at #CellBio24 and will talk about her unpublished NPC biogensis work tomorrow!
Check it out and say hello 🙌🏼
We are now on Bluesky!
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
