Holly Sullivan-Toole

🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵

Link: www.biorxiv.org/content/10.6...

1/10

New preprint from the lab! Led by @martingell.bsky.social .

There is something for everyone: brain-behavior prediction, latent variable modeling, test-retest reliability. 🧠📈📊

"Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models"

Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale The rapidly evolving field of computational psychiatry enables quantification of specific cognitive processes, and their underlying mechanisms, in a translational and potentially scalable manner, usin...

Excited to share our latest paper in which we discuss merging theory-and data- driven computational psychiatry in a large transdiagnostic cohort study (N=2400)

www.biologicalpsychiatrycnni.org/article/S245...

Christopher Pittenger, Godfrey Pearlson @annierhcheng.bsky.social @sobp-org.bsky.social

The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls - Neuropsychopharmacology Neuropsychopharmacology - The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls

🚨🚨New paper day!🚨🚨
Wonderful work from the longitudinal arm of our cannabis-users study showing how brain reward-system function changes over 12 months in regular users. 🧵⬇️ #neuroskyence
www.nature.com/articles/s41...

Dopamine Supports Reward Prediction to Shape Reward-Pursuit Strategy Reward predictions not only promote reward pursuit, they also shape how reward is pursed. Such predictions are supported by environmental cues that signal reward availability and probability. Such cue...

🚨📃New Wassum Lab Paper 📃🚨

Out today, Melissa Malvaez, Nick Griffin, Andrea Suarez & team discovered that dopamine can enable reward predictions to shape how we pursue reward.

Surprisingly, we find that dopamine can constrain instrumental reward seeking.

www.jneurosci.org/content/46/8...

🧵👇🏻

Haha, well, my running speed is basically a walking speed but the new temp achieved means I can get out more in winter than I thought which is awesome!!!

I’ve got a list too……only willing to share the highlight reel right now: I went for a run in 35 degrees, which I didn’t know I could do!! And I’ve got an idea I’m in love with….but now to turn it into something…

#eNeuro: Findings in rats from Boven et al. reveal that the cerebellum doesn't just fine-tune our movements but can also actively compute our internal sense of time, helping link between what we perceive and how we act. https://doi.org/10.1523/ENEURO.0198-25.2025

#eNeuro: Findings from Soma et al. reveal how reward-related information is hierarchically distributed across the rat's brain. https://doi.org/10.1523/ENEURO.0256-25.2026

OK I swear a saw a cartoon about a mediation analysis being 3 correlations in a trench coat but I can't find it

and searching online just gives me a lot of trench coats 😂

does anyone have this? @dingdingpeng.the100.ci in my mind you were involved but I might have made it up

I also really like working with new researchers!! Their enthusiasm is better than coffee!!!

Stand With Minnesota Stand With Minnesota is a hub for supporting, learning, and taking action to support Minnesotans impacted by ICE and federal enforcement.

Rent assistance is a HUGE need right now. People have drained their savings in hiding for months and now they’re losing their homes too.

If you need ideas about where to send your money:

Prefrontal neural geometry of learned cues guides motivated behaviours - Nature The dorsomedial prefrontal cortex encodes the value, salience and valence of learned stimuli along distinct neural dimensions, and the geometry of these representations shapes motivated behaviours in ...

Can you easily distinguish between value, valence, and salience?

Probably not, but the prefrontal cortex of mice seems to achieve this by creating a sort of multidimensional orthogonal neural space, where each dimension corresponds to one of these subjective elements

www.nature.com/articles/s41...

The Role of Memory in Temporal Discounting A widely observed phenomenon in intertemporal choice is temporal discounting; people prefer to have rewards sooner rather than later, even if the delayed rewards are larger. Despite the universality o...

So excited that this textbook, edited by @dfareri.bsky.social @dvsmith.bsky.social & @thepsychologist.bsky.social is out now! And so happy to have been invited to contribute. Here’s my chapter on the role of memory, esp. semantic memory, in temporal discounting: link.springer.com/chapter/10.1...

New paper in Imaging Neuroscience by Nina Raduner, Silvia Brem, et al:

Neural and behavioural differences in multisensory statistical and reinforcement learning across development and task variants

doi.org/10.1162/IMAG...

Third immigrant detainee at facility in El Paso has died, ICE says Camp East Montana on Fort Bliss in El Paso is one of the largest ICE detention centers in the country.

www.nbcnews.com/news/us-news...
Watch MADDOW

"IF THEY BUILD THEM
THEY WILL FILL THEM"

This detention center is at Fort Bliss near El Paso TX. Houses roughly 3K human beings
They're in TENTS
Horrendous conditions
3 PEOPLE DIED THERE, ONE DEATH now a homicide

Call Your Reps PLS
202 224-3121

I can’t handle this. Please stop.

Nine subcortical/cerebellar atlases included in the subcortex_visualization Python package (and subcortexVisualizationR package in R). The atlases are depicted in two-dimensional vector graphic format.

The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)!

Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...

My current hero is Ser Duncan the Tall, Knight of the Seven Kingdoms. He's making a lot out of a little, and his next adventure airs at 9pm CST.

in an ideal world the trauma this couple went through *shouldnt* resonate stronger than a latino family terrorized by ice. but we dont live in that world. we live in the real world. so i applaud it when the most minnesota people possible link arms with us and FIGHT like this.

Love to see leaders using their platforms for good. Check out the links in this thread for ways to help in Minneapolis!

Let’s do better. Links to other victims of ICE/CBP God Fund Me sites are provided in the comments. Please R/T.

How many versions of the Iowa Gambling Task (IGT) exist? And how much does this affect research using the IGT? More than you might think. 🧵

The Iowa Gambling Task is an extreme example of Jingle Fallacy and schmeasurement.

In 100 articles we found 244 different ways of scoring it, 177 were never reused. Correlations between them range -.99 to .99.

At the same time, we show meta-analyses combine these results as if they’re equivalent.

I wasn't going to share but then I saw the request from his parents

A friend here in Minneapolis who knew Alex Pretti just texted our group that Alex was "super cool laid back and a great guy"

ICE agents beat and executed a man in public in Minneapolis this morning

NIH grant writing people, do you have thoughts on the use of "I statements" in F fellowships and K training grant apps?

I thought someone told me once to use "I will", "I propose" in training-focused apps to emphasize independence, but maybe it sounds arrogant?

Another friend put it to me like this: "ICE has made the classic Nazi mistake. They've invaded a winter people in the winter."

Why in the world are we not screening all pregnant people for iron deficiency when we know it’s associated w/ bad outcomes for mom & baby, affects the vast majority of pregnancies & is easily diagnosed & treated?!

Oh I forgot.

We don’t care about women or children.

tinyurl.com/Ironpreg