International Journal of Particle Therapy

Figure 1. C-DoTA architectures. Left: Vanilla DoTA, with a convolutional encoder passing the normalized BEV-CT as a sequence of 2D images to the transformer block, together with the normalised energy E, used for dose prediction (C-DoTA-d). Right: The architecture for predicting α and β parameters is expanded by an additional convolutional encoder and transformer with the predicted dose as an input. The output of both transformers for CT and predicted dose is finally processed by a third transformer block using cross attention.

Read new research from our #AI in #ParticleTherapy special issue which presents the 1st AI dose engine for #CarbonIonTherapy: sciencedirect.com/science/arti... #MedicalPhysics #radonc #DeepLearning #AIinHealthcare #TreatmentPlanning #AdaptiveRadiotherapy #RBE

Fig. 3. Imaging visibility assessment using the Rando phantom: (a) kV portal and orthogonal images acquired on the proton system (Imaging parameters: 120kV/320mA/320ms).

A step toward simpler, more precise multi-modal RT? Read about universal fiducial markers that could enhance workflow efficiency & treatment accuracy - www.sciencedirect.com/science/arti... #Radiotherapy #MedicalPhysics #InnovationInMedicine #ParticleTherapy #CancerResearch #Imaging #RadOnc

Fig. 1. Number of ophthalmic patients treated per center. Total since center opening (line) and annual average (2015 to 2023, inclusive, bars).

Discover the latest global trends and practices in ocular particle therapy, in press now with IJPT - 🔗 www.sciencedirect.com/science/arti... #particletherapy #protontherapy #ocular #choroidamelanoma #uvealmelanoma #PTCOG #survey

“Proton therapy is not simply a sharper version of photons. It is a fundamentally different modality - one that demands new thinking, new workflows, and a new level of vigilance.” Read about Dr. Ashu Abhishek’s experience with IJPT now: www.sciencedirect.com/science/arti...

Figure 1. Overall survival by Surgery or No Surgery.

#AdenoidCysticCarcinoma of the #HeadAndNeck is rare & aggressive, with high risks of perineural invasion, recurrence, & metastasis. #ProtonTherapy may offer an effective #Reirradiation option - read the study in press: 🔗 www.sciencedirect.com/science/arti... #HeadAndNeckCancer #CancerResearch

Fig. 2. Proton dosimetry plan of the single patient who developed in-field secondary malignancy (papillary thyroid carcinoma) 11.9 years after consolidative proton therapy. The lime green represents the PTV contour, and the turquoise blue represents the thyroid contour. Abbreviations: PTV, planning target volume.

Start off the New Year with a #UFProtonTherapy #UFRadOnc #Nemours #allchildrens #UMiamiHealth study presenting outcomes of pediatric patients with classical #Hodgkin lymphoma receiving consolidative #protontherapy: www.sciencedirect.com/science/arti...

Wishing everyone around the world a safe, happy, and peaceful holiday season ❤️ 🎁

64th Annual PTCOG Conference | 8-13 June 2026 | Deauville, France PTCOG 64 – Join us from 8-13 June 2026 in Deauville, Normandy, France. Discover the latest research, innovations, and clinical advancements in particle therapy.

Only 1 month left to submit your abstract for #PTCOG64!

Share your research & innovations in particle therapy before 13 Jan 2026!!

🔗 Learn more here: ptcog64.org

Vol.18 is online: advances in #proton & #carbon-ion therapy including improved target coverage for #pancreaticcancer, proton reirradiation for #lungcancer, automated #QA /planning, treatment-time benchmarks, and #radiobiology insights: www.sciencedirect.com/journal/inte...

“Hadrons for Life: The 19th Seminar of HITRIplus” is now available with IJPT - sciencedirect.com/special-issu... #HadronTherapy #ParticleTherapy #CancerResearch #HITRIplus

Figure 1. Kaplan-Meier curves for local, regional, and distant control and overall survival.

During l#LungCancerAwarenessMonth, we are pleased to present a study demonstrating the feasibility and efficacy of a hypofractionated course of #proton reirradiation for recurrent thoracic tumors - in press now: www.sciencedirect.com/science/arti...

Figure 1. Assumption of a constant relative biological effectiveness (RBE) of 1.1: Responses on the level of (a) overall concern [Q3] and (b) urgency for revision of current practice for normal tissue [Q4]. Distribution in percent (number of responses).

Read the results of an important survey of 29 U.S. proton therapy centers assessing awareness and management of relative biological effectiveness variability in clinical practice: www.sciencedirect.com/science/arti...

Fig. 1. Workflow for archetypal and modeling analysis of optical damage pattern evaluation after radiotherapy.

Our first AI in Particle Therapy Special Issue article is available! Learn how a novel #AI approach models the evolution of visual field deficits in patients with para-optic tumors treated using pencil beam scanning #protontherapy - www.sciencedirect.com/special-issu...

Fig. 1. Representative color wash images in axial (left), coronal (middle), and sagittal (right) planes comparing protons (top row) versus photon (bottom row) based SBRT dose deposition for primary RCC. As shown, the target receives similar coverage in the two planes, with greater sparing of nearby structures with protons including the healthy part of the kidneys, stomach, bowel and liver.

In press now: #kidneycancer represents 4% of all new #Cancer cases in the US. Read a study that suggests #Proton based #SBRT improves target coverage while reducing the dose to primary renal cell carcinoma patient OARs: www.sciencedirect.com/science/arti...

Fig. 1. Diagram of the proton clinic RTLS sensors/zones. The colors indicate room status (green for available and yellow for occupied).

Numerous factors influence #protontherapy treatment times & with 29 new centers opened in the last 5 years, #NAPT reports these patients have tripled. Read treatment time insights from the Miami Cancer Institute’s RTLS system #RTLS system - www.sciencedirect.com/science/arti... #cancer #radonc

Fig. 2. Treatment plan review workflow incorporating Auto-IniCheck for initial plan assessment. Auto-IniCheck is integrated into the initial plan review process for dosimetrists and physicists to enhance error detection and improve review efficiency. The figure illustrates the use of Auto-IniCheck with manual checks, streamlining the initial review process.

In press now: Read a UF Health Proton Therapy study that developed & validated an automated framework for #protontherapy plan review, enhancing error detection capabilities & workflow efficiency in pencil beam scanning: www.sciencedirect.com/science/arti... #PBS #radonc #MedPhys #cancerresearch

Fig. 1. Alignment Issue Caught by CBCT. In both the CBCT and the QACT, the alignment is to the fiducials and it can be observed that the bony anatomy is then very off. This resulted in an adaptive plan. This highlights the usefulness of CBCTs in identifying patient anatomical changes that can reduce the standard QACT rates, instead triggering a QACT if anatomical changes, such as this bony vs fiducial alignment difference, are observed on CBCTs.

Excessive quality assurance computed tomography scans can increase patient burden, resources, & #healthcare costs. Read a John Hopkins School of Medicine study evaluating the impact of standardized minimum #QACT frequencies across treatment sites - sciencedirect.com/science/arti... #MedPhys #Cancer

Figure 1. Experimental Materials. Figure 1A shows how differentiation is induced in MC3T3-E1 and RAW264.7 cells. Figure 1B illustrates the method of verifying the bystander effect and the structure of the items used for the experiment. Abbreviations: RANKL = receptor activator of nuclear factor kappa-B ligand.

In press now: Read a collaborative Juntendo-Harvard study that suggests both #Xrays and #protons may induce #radiation-induced bystander responses in osteoblasts and osteoclasts, irrespective of cell combination, dose, or radiation type: www.sciencedirect.com/science/arti...

Volume 17 is online now! Read articles related to #IMPT Versus #IMRT for #BreastCancer, #Protons or #Photons in pituitary #neuroendocrine tumors, NTCP-based prediction of lung sparing with IMPT, and more: www.sciencedirect.com/journal/inte...

Fig. 3. Summed dose distribution of the two treatment plans Sum of the dose from external beam photon radiotherapy and carbon ion radiotherapy, expressed in EQD2.

Clear cell #adenocarcinoma of the uterine cervix is a rare and aggressive subtype of #cervicalcancer, typically resistant to conventional #RT. Read a case report in press with IJPT that suggests a #CIRT boost can achieve long-term local control: www.sciencedirect.com/science/arti... #cancerresearch

Thank you Dr. Deasy! As far as we know, there is no widely consolidated dataset that directly links cell cycle arrest with linear energy transfer (LET) in a clinical setting - would anyone else out there on Bluesky have information on this?

Fig. 5. Medras accurately predicts radiation response in different cell models, shown by the correlation between Medras-predicted and experimentally obtained MID values.

Understanding how cells respond to & repair DNA damage is crucial for optimizing #radiotherapy - a new study evaluates how loss of different #DNA DSB repair genes impacts radiosensitivity: www.sciencedirect.com/science/arti... #MedPhys #RadOnc #ParticleTherapy #CancerResearch #protontherapy

Registration is now open for the #PTCOG-NA 11th Annual Meeting in Shreveport November 7-9, 2025. Take advantage of Early Bird Rates until August 20th! Learn more: www.ptcog-na.org/ptcog-na-11t...

Protons or Photons in Pituitary Neuroendocrine Tumors– That is Not the Question With the long-life expectancy of patients with pituitary neuroendocrine tumors (PitNETs), reducing long-term toxicity is essential to preserve quality…

In press with IJPT now: a collaborative Oslo University Hospital team investigates whether 2- or 3-field #PBT plans better spare #OARs than #VMAT: www.sciencedirect.com/science/arti... #MedPhys #RadOnc #ParticleTherapy #CancerResearch #protontherapy

Fig. 1. Experimental setup for the X-ray computed tomography polymer gel dosimeter (XCT-PGD). (a) Schematic diagram of the gel dosimeter in a cylindrical container placed inside an absorber. (b) Photograph of the actual setup on the treatment couch. The gel dosimeter is placed in an absorber and positioned using external lasers so that the center of its sensitive region aligns with the mechanical isocenter. The dosimeter is then secured in place with adhesive tape.

In press with IJPT - learn about a novel method using an #XCT-PGD with on-board #CBCT for comprehensive 3D verification of #proton beam delivery accuracy: www.sciencedirect.com/science/arti... #MedPhys #RadOnc #ParticleTherapy #CancerResearch

Volume 16 is complete & online now, featuring articles on #medulloblastoma from the Pediatric Proton/Photon Consortium Registry #PPCR, operational improvement of a #protontherapy system, & more: sciencedirect.com/journal/inte... #CancerResearch #radonc #MedPhys

From Fig. 1. The irradiation field diagrams of IMPT and IMRT (A) and illustration of cardiac substructures delineation, mean dose, and isodose line distribution for IMPT and IMRT in left-sided (B) and right-sided (C) patients. Note: The mean dose to cardiac substructures is measured in cGy(RBE).

In press now with IJPT: #IMPT vs. #IMRT provides excellent cardiac protection, particularly for left-sided IMNI and high-risk #breast cancer patients - learn more: www.sciencedirect.com/science/arti...

Fig. 1. Dosimetric Savings of 2 mm Plans. The dosimetric difference for each OAR clinical goal is shown for each patient.

In press now: Learn how a tailored #QACT schedule based on beam trajectory and target location reduces unnecessary imaging without compromising treatment accuracy in cranial #protontherapy : sciencedirect.com/science/arti... #particletherapy #radonc #MedPhys

IJPT #cancerresearch article highlighted by U.S. News and World Report: www.usnews.com/news/health-...

Fig. 1. Angular distribution of gantry angle vs. selected beam energy and number of protons per control point for SPArc-step&shoot and SPArc-dynamic.

Learn about the development of #step-and-shoot arc therapy (SPArc-step&shoot) for #headandneck #cancer treatment @BeaumontRadOnc @CorewellHealth - in press now with IJPT: www.sciencedirect.com/science/arti... #RadOnc #protontherapy