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Josie Bryant

@josiebryant

Group Leader at Wellcome Sanger Institute. Using omics to understand chronic lung infections and lung microbiomes in disease

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18.11.2024
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Latest posts by Josie Bryant @josiebryant

Meme of machines sparing humans who spoke politely to AI.

Meme of machines sparing humans who spoke politely to AI.

I always speak politely to AI as there is a non-zero chance that this will be a situation in the future:

04.03.2026 09:11 πŸ‘ 126 πŸ” 18 πŸ’¬ 3 πŸ“Œ 2
PearTree β€” Phylogenetic Tree Viewer

So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here: artic-network.github.io/peartree (click the β€œExample...” button for immediate candy and then click every button you can find).

28.02.2026 19:01 πŸ‘ 163 πŸ” 100 πŸ’¬ 5 πŸ“Œ 4
Unrooted phylogeny indicating the major clades of Mycobacterium bovis found in Ireland.

Unrooted phylogeny indicating the major clades of Mycobacterium bovis found in Ireland.

The genomic diversity and spatial patterns of Mycobacterium bovis in Ireland revealed by whole genome sequencing rdcu.be/e50zT

27.02.2026 10:42 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Terrible headline (this is NOT what the new research - link below - shows!), terrible AI image! Argh!
Here’s the actual research:
www.science.org/doi/10.1126/...

Where do I start?! 1/4

27.02.2026 11:13 πŸ‘ 826 πŸ” 226 πŸ’¬ 64 πŸ“Œ 33
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In case you missed it: our review titled "Spatial structure: shaping the ecology and evolution of microbial communities" is out! 🚨

Let me hit you with some highlights on why spatial structure matters. (and why you should care!)

Sharing is appreciated πŸ™ πŸ§΅πŸ‘‡

doi.org/10.1093/fems...

25.02.2026 13:06 πŸ‘ 137 πŸ” 83 πŸ’¬ 3 πŸ“Œ 2

Amazing Daniela!!! So pleased to see this 🌟

18.02.2026 19:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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AlphaFold Database welcomes community datasets Latest AlphaFold Database update adds high-value datasets for microbial and viral proteins, generated by specialist communities

Delighted to see over 17 million new protein structure predictions from novel proteins in AllTheBacteria are now integrated into the AlphaFold Database at @ebi.embl.org !
Huge work from @gbouras13.bsky.social @oschwengers.bsky.social and friends to generate these.

www.ebi.ac.uk/about/news/u...

17.02.2026 13:52 πŸ‘ 97 πŸ” 26 πŸ’¬ 1 πŸ“Œ 2
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Incredible time at #AIR2026 covering breadth of respiratory infection, microbiomes and immunology with some really beautiful biology. Thanks to fellow committee members @resp-micro.bsky.social @drclairesmith.bsky.social @ewanharrison.bsky.social , Alex Kayongo and organisers @eventswcs.bsky.social

13.02.2026 18:39 πŸ‘ 14 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Fantastic final day at #AIR2026. A masterclass in in vitro modelling by Scott Randall followed by a great panel discussion with funders @asthmaandlung.org.uk @wellcometrust.bsky.social @cysticfibrosis.org.uk @karlstaples.bsky.social

13.02.2026 16:53 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Another insightful day of science, discussion and making new friends at #AIR2026

Day 2 Highlights: making sense of big data, spatial transcriptomics and in vitro modelling of respiratory infections @eventswcs.bsky.social @sangerinstitute.bsky.social

12.02.2026 18:33 πŸ‘ 4 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0

Always good to be back at Wellcome Genome Campus, this time for the #AIR2026 conference on Genomic and systems approaches to respiratory infection, microbiomes and immunity

11.02.2026 13:11 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

How do bacterial pangenomes evolve, what controls their dynamics, why do they exist?
Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle

09.02.2026 10:55 πŸ‘ 71 πŸ” 32 πŸ’¬ 1 πŸ“Œ 0
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MRC instructs grant review boards to slash funding rates - Research Professional News Boards asked to recommend just three applications for funding, as BBSRC also suspends calls

Startling that this is being broadcast in the absence of any public communications by @ukri.org

The academic community has a right to expect to be told first hand what is happening with response mode funding and what the immediate future looks like

www.researchprofessionalnews.com/rr-news-uk-r...

30.01.2026 09:16 πŸ‘ 26 πŸ” 20 πŸ’¬ 2 πŸ“Œ 3
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Research Group Leader Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...

We are hiring for group leaders again β€” EBI is a great place to start your research group!

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

30.01.2026 09:02 πŸ‘ 66 πŸ” 89 πŸ’¬ 0 πŸ“Œ 2
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EMBL is deeply saddened by the passing of our Interim Director General Peer Bork, a pioneering scientist who left an indelible imprint on life science research in Europe and beyond.

We extend our deepest condolences to his family, friends, and colleagues.

www.embl.org/news/people-...

22.01.2026 07:40 πŸ‘ 109 πŸ” 44 πŸ’¬ 1 πŸ“Œ 4
AIR 2026: Genomic and Systems Approaches to Respiratory Infection, Microbiomes and Immunity β€” 20260211 Course exploring how genomics, microbiome profiling, and systems biology reshape our understanding of respiratory infections and immune dynamics.

🫁 AIR 2026 registration closing 19th Jan

Focused on respiratory infection, microbiomes and immunity, with amazing speakers.
Incl genomics, single-cell, spatial and systems approaches.

πŸ“ Wellcome Genome Campus
πŸ“… 11–14 Feb

coursesandconferences.wellcomeconnectingscience.org/event/air-20...

08.01.2026 15:31 πŸ‘ 4 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
Client Challenge

Our first lab paper is out.
Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes.
From single cells to patients, across tuberculosis and M. abscessus.
πŸ‘‰ doi.org/10.1038/s415...
πŸ‘‡ Thread

12.01.2026 07:26 πŸ‘ 18 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1

@eventswcs.bsky.social

08.01.2026 15:31 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
AIR 2026: Genomic and Systems Approaches to Respiratory Infection, Microbiomes and Immunity β€” 20260211 Course exploring how genomics, microbiome profiling, and systems biology reshape our understanding of respiratory infections and immune dynamics.

🫁 AIR 2026 registration closing 19th Jan

Focused on respiratory infection, microbiomes and immunity, with amazing speakers.
Incl genomics, single-cell, spatial and systems approaches.

πŸ“ Wellcome Genome Campus
πŸ“… 11–14 Feb

coursesandconferences.wellcomeconnectingscience.org/event/air-20...

08.01.2026 15:31 πŸ‘ 4 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Convergence and global molecular epidemiology of Klebsiella pneumoniae plasmids harbouring the iuc3 virulence locus: a population genomic analysis Klebsiella pneumoniae is an important pathogen of humans and animals. In the past five years, increasing reports of convergent strains that carry both…

It has been a long road, but our paper on Klebsiella plasmids is finally out in Lancet Microbe. Thanks to all co authors but especially Marjorie Gibbon and Natacha Couto www.sciencedirect.com/science/arti...

07.01.2026 14:13 πŸ‘ 38 πŸ” 25 πŸ’¬ 3 πŸ“Œ 0
Postdoctoral Fellow – A variant to function map of lung cancer Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

new year, new job?!

Exciting postdoc position opening in my lab at the Wellcome Sanger Institute. Fully funded by CRUK

sanger.wd103.myworkdayjobs.com/en-US/Wellco...

find out more at www.coelho-lab.com

06.01.2026 16:36 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1

We're organising a microbes & deep learning session at SMBE next year -- looking forward to seeing your abstracts!

15.12.2025 11:26 πŸ‘ 14 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0

Official Statement:
Cambridge University, Department of Veterinary Medicine, 12/12/2025

"The decision to recommend the closure of what the Times Higher Education Supplement ranks as the best undergraduate veterinary course in the world has come as a bolt from the blue."

[1]
#SaveTheVetSchool

12.12.2025 12:38 πŸ‘ 1 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1

Organised by @eventswcs.bsky.social with @resp-micro.bsky.social @ewanharrison.bsky.social, Alex Kayongo and Claire Smith

11.12.2025 12:41 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Plus a meet the funders session to discuss funding for respiratory biology with Alex Pym @wellcometrust.bsky.social, Paula Sommer @cysticfibrosis.org.uk, Samantha Walker @asthmaandlung.org.uk and Karl Staples @balrcommunity.bsky.social

11.12.2025 12:41 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Accommodation available onsite at Hinxton hall with the conference dinner at the beautiful Fitzwilliam Museum

11.12.2025 12:41 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

We have an amazing line up of speakers including Miriam Moffat, Daniela Ferreira, Emmanuel Saliba @emmanuel-saliba.bsky.social, Nick Loman @pathogenomenick.bsky.social, Duncan Ng @duncan-ng.bsky.social and many more

11.12.2025 12:41 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Work on respiratory immunology or microbes? Interested in big data, omics or the latest in vitro models?... Treat your lab to a christmas present of AIR 2026 registration!

Feb 11th-13th, registration closing soon:
coursesandconferences.wellcomeconnectingscience.org/event/air-20...

11.12.2025 12:41 πŸ‘ 4 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0
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The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin Accumulating evidence has connected the chemically unstable, DNA-damaging gut bacterial natural product colibactin to colorectal cancer, including the identification of mutational signatures that are ...

Colibactin-DNA interstrand crosslinks structure reveals DNA-damaging acitivity of colibactin that is linked to colorectal cancer #MicroSky www.science.org/doi/10.1126/...

04.12.2025 22:07 πŸ‘ 21 πŸ” 10 πŸ’¬ 1 πŸ“Œ 1

Great to share the latest work from our group and collaborators. First CARRIAGE study paper led by @drdaggarwal.bsky.social and the heroic efforts of Katie Bellis and Beth Blane in the lab plus all the team at @cambridge-ceu.bsky.social Huge thanks goes to the 22,000 participants of the study

02.12.2025 15:09 πŸ‘ 10 πŸ” 11 πŸ’¬ 1 πŸ“Œ 0