Adriano Bolondi's Avatar

Adriano Bolondi

@adrianobolondi

Researcher @crg.eu, previous MeissnerLab @molgen.mpg.de. Interested in how cells and genes make embryos. #EMBO & #MSCA fellow

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17.01.2025
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Latest posts by Adriano Bolondi @adrianobolondi

Three more weeks to apply and join us in Barcelona!

Help us understanding how oocytes regulate proteostasis and fertility!

Find here more detailed information on the call:
recruitment.crg.eu/content/jobs...

Please spread around your communities!

09.03.2026 13:04 πŸ‘ 4 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Young PI Symposium 2026 Visit the post for more.

Today we present another of our amazing speakers: @anne-schreiter.bsky.social the executive director from @gso-forresearchers.bsky.social. She will give us an interactive workshop about Leadership and Team-building.

Register to our @fens.org Satellite πŸ‘‰ youngpisymposium2026.com

06.03.2026 10:33 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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🚨 Job Alert - Please share! πŸ™

Interested in 3D gene regulation in development & evolution? πŸ€“πŸ§¬

πŸ’₯ Our lab at @cabd-upo-csic.bsky.social is expanding!

We’re recruiting:
βœ… PhD students
βœ… Postdocs
πŸ’»πŸ§ͺ Experimental or computational backgrounds welcome

πŸ‘‡ Details below

06.03.2026 10:14 πŸ‘ 22 πŸ” 20 πŸ’¬ 1 πŸ“Œ 3
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🚨JOB ALERT🚨PLEASE SPREAD and RT

Searching for a motivated Master’s student @bokelab.bsky.social @crg.eu @prbb.org to investigate how proteostasis in oocytes influences dormancy and fertility.

Reach out to me (adriano.bolondi@crg.es) to join us in sunny Barcelona!

See details belowπŸ‘‡

05.03.2026 14:21 πŸ‘ 6 πŸ” 15 πŸ’¬ 0 πŸ“Œ 2
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The ISSCR is pleased to announce that Alexander Meissner, Director of Max Planck Institute for Molecular Genetics, Germany, has been named the recipient of the 2026 ISSCR Momentum Award, supported by BlueRock Therapeutics!

Learn more: https://ow.ly/eUNt50YoFm3

03.03.2026 16:05 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Young PI Symposium 2026 Visit the post for more.

Deadline extended until end of March!

Join our @fens.org Satellite πŸ‘‰ youngpisymposium2026.com

03.03.2026 08:53 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Interested in doing a PhD in tumor mechanobiology?

At UniversitΓ© Paris-Saclay, the upcoming PhD selection process is open, and I’m looking to put forward a candidate to join my lab.

If you’re excited about uncovering how mechanical signals regulate tumor progression, please get in touch!

24.02.2026 13:08 πŸ‘ 13 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0

We wrote a piece on how easy it is to write gene regulatory sequences. - Turns out, it isn't that easy even though we know a lot about cis-regulation.

huge credit to @carldeboer.bsky.social to seeing this through so our thoughts aren't lost. I promise, it's a worthwhile read!

27.02.2026 08:27 πŸ‘ 28 πŸ” 12 πŸ’¬ 0 πŸ“Œ 0
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Charting single-cell lineages with synthetic and natural barcodes - Nature Reviews Genetics In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...

INTERESTED IN SINGLE-CELL LINEAGE TRACING?

Check our new review @naturerevgenet.bsky.social from the @alejofraticelli.bsky.social lab πŸŽ‰πŸŽ‰

nature.com/articles/s41...

With Victoria Parreno, we tried to update the modern manual for genetic tracing and clonal analysis.

Read link: rdcu.be/e50gy

27.02.2026 12:31 πŸ‘ 29 πŸ” 9 πŸ’¬ 1 πŸ“Œ 0
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Thanks to everyone who joined us at the 2nd Meeting on Early Embryogenesis & Epigenetics last weekβ€”great talks and valuable discussions across the community! Huge thanks to our partners at the Weizmann, the speakers, session chairs, and all the behind-the-scenes helpers! www.molgen.mpg.de/embryo2026

25.02.2026 14:02 πŸ‘ 13 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental condi...

Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate www.nature.com/articles/s41... #jcampubs

25.02.2026 17:06 πŸ‘ 51 πŸ” 23 πŸ’¬ 0 πŸ“Œ 2
Redirecting

Our most recent work on the β€œfunction and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the threadπŸ‘‡ for the highlights of our findings.

25.02.2026 16:01 πŸ‘ 122 πŸ” 59 πŸ’¬ 9 πŸ“Œ 5
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Young PI Symposium 2026 Visit the post for more.

@tjryan.bsky.social will join the @fens.org satellite @young-pi-neuro26.bsky.social as a keynote speaker. He is Professor of Neuroscience at @tcddublin.bsky.social and Chair of the FENS Advocacy Committee. He will speak about advocacy for neuroscience in Europe. Join us πŸ‘‰ youngpisymposium2026.com

24.02.2026 17:17 πŸ‘ 5 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1
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Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 Happy to see that my PhD work is finally published!

We present METALoci, a tool that integrates #3Dgenome and #Epigenetics to identify regulatory hubs.

Applied to #sexdetermination we uncover:
βœ”οΈ Non-coding regulatory region controlling Fgf9
βœ”οΈ Meis genes as key players

πŸ‘‰ rdcu.be/e5sm2

24.02.2026 15:40 πŸ‘ 43 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🀩πŸ’ͺ Out now! 3D regulatory hubs in sex determination

With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social

1️⃣ METALoci – explore #3DGenome 🧬
2️⃣ Non-coding region controlling Fgf9 🧩
3️⃣ Meis genes = new key players 🌟

πŸ‘‰ rdcu.be/e5sm2

1/n Bluetorial πŸ‘‡

24.02.2026 14:02 πŸ‘ 59 πŸ” 26 πŸ’¬ 1 πŸ“Œ 2

🚨Last week to register!!
Noelia AntΓ³n BolaΓ±os is one of our amazing keynote speakers. She will tell us all about her journey from Spain to Boston, and starting her lab at @umcutrecht.bsky.social πŸ›«πŸŒŽπŸ›¬.

Join our @fens.org Satellite event in Barcelona!

23.02.2026 21:06 πŸ‘ 5 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Young PI Symposium 2026 Visit the post for more.

yo πŸ¦‹ NEURO SKY πŸ“£ the website is live and registration open for the Young PI Symposium 2026 - the day prior to FENS Barcelona! @young-pi-neuro26.bsky.social

navigate challenges, sharpen leadership skills, make a roadmap together for generations of neuroscientists!
youngpisymposium2026.com

15.01.2026 17:04 πŸ‘ 6 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1
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Young PI Symposium 2026 Visit the post for more.

πŸ“’Are you a young PI or senior postdoc in neuroscience looking to embark on the challenging journey of starting your own lab?

πŸ“†Then save July 5, 2026 in your calendar and join us in Barcelona for the second Young PI Symposium.
youngpisymposium2026.com

13.12.2025 14:59 πŸ‘ 7 πŸ” 5 πŸ’¬ 0 πŸ“Œ 3
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🧬 We are excited to announce the
INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026
β€” Engineering the Origins of Life

πŸ“… 7–8 May 2026
πŸ“ Utrecht, The Netherlands

Register & submit abstracts:
www.oncodeinstitute.nl/internationa...

13.02.2026 09:47 πŸ‘ 4 πŸ” 2 πŸ’¬ 1 πŸ“Œ 2
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Once your 3D sample is reconstructed, you can rotate, take virtual sections in any orientation, project gene expression through depth, link 3D space with UMAP, and compute spatial differential expression on the reconstructed volume to find region-enriched genes.

06.02.2026 14:14 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607

06.02.2026 14:13 πŸ‘ 19 πŸ” 9 πŸ’¬ 1 πŸ“Œ 0
A confocal image of a 3D human Trunk-like Structure (hTLS) made from pluripotent stem cells, showing a neural tube (cyan) and segmented somites (magenta).

A confocal image of a 3D human Trunk-like Structure (hTLS) made from pluripotent stem cells, showing a neural tube (cyan) and segmented somites (magenta).

We're recruiting a #devbio Postdoctoral Fellow to explore the hTLS system! If you know any fab PhD students finishing, or candidates wanting to get their hands on #SCBEM embryo models, do get them to apply! 🌟https://www.crick.ac.uk/careers-study/vacancies/2026-02-03-postdoctoral-fellow-moris-lab

05.02.2026 18:28 πŸ‘ 14 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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EMBL scientists Jamie Hackett and Robert Prevedel have been awarded ERC Proof of Concept grants to support the translation of innovative ideas into tangible therapeutic and imaging tools.

www.embl.org/news/awards-...

@erc.europa.eu @jamiehackett.bsky.social

27.01.2026 12:24 πŸ‘ 16 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

We wrote a protocol article detailing induction of dormancy in stem cells, embryos, and blastoids. We hope that it is useful to the community. As usual fun to work with @nicolasrivron.bsky.social, Heidar and Dhanur.

26.01.2026 18:55 πŸ‘ 20 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0
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Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some πŸ”₯ new results in here since the biorvix incl (1) a new RARE-GFP reporter βœ³οΈπŸ™Œ, (2) additional NMP quantification πŸ”’, (3) no neural tube patterning on RA inhibition πŸ™… etc. Enjoy! 😍 www.nature.com/articles/s41...

16.12.2025 10:04 πŸ‘ 87 πŸ” 33 πŸ’¬ 5 πŸ“Œ 0
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Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.

πŸŽ‰ Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! πŸ₯³ So nice to see it in its final form after the preprintβ€” and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...

02.12.2025 09:14 πŸ‘ 65 πŸ” 21 πŸ’¬ 5 πŸ“Œ 2
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Doctoral INPhINIT fellowships - Incoming Call 2026 We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.

Outstanding PhD fellowship call OPEN for excellent students.

lacaixafoundation.org/en/doctoral-...

This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).

If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!

26.11.2025 07:43 πŸ‘ 17 πŸ” 20 πŸ’¬ 1 πŸ“Œ 2
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Proteome-wide model for human disease genetics Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.

popEVE is out in Nature Genetics! πŸŽ‰
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K

24.11.2025 13:35 πŸ‘ 50 πŸ” 20 πŸ’¬ 2 πŸ“Œ 1
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Single-cell activation screen identifies hepatic maturation regulators with zonal resolution The maturation of lineage-committed embryonic hepatocytes requires both the timed activation of metabolic gene regulatory networks (GRNs) and silencin…

Happy to see Atsuhiro Taguchi's work on genes involved in liver zonation published in Dev @cellpress.bsky.social. Kudos to all authors at @molgen.mpg.de #MeissnerLab #HniszLab. Grateful for the opportunity to help!

www.sciencedirect.com/science/arti...

21.11.2025 10:45 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
The on-site, on-demand, neuronal gene machine - Nature Reviews Neuroscience In this Journal Club, Matthew Kraushar discusses a study published in 1996 that found a role for local protein translation in hippocampal synaptic plasticity.

check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).

cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!

www.nature.com/articles/s41...

18.11.2025 18:35 πŸ‘ 14 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1