Stephan Uphoff

Selective elimination of donor bacteria enables global profiling of plasmid gene expression at early stages of conjugation Abstract. Conjugative plasmids are a major driving force for the dissemination of antimicrobial resistance. During conjugation, plasmid DNA is transferred

academic.oup.com/nar/article/... Collaboration with Y. Yamaichi. Killing donor bacteria in conjugation mixes using water enables transcriptomic profiling of early plasmid genes ! Superb tool for studying zygotic induction of these early genes, which include anti-SOS and anti-RM factors. #microsky

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

With evidence attached 😊
#BioPhyChrom2025
@biochemsoc.bsky.social @biophychrom.bsky.social
@damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @lauraspagnolo.bsky.social @tamarabasta.bsky.social

Next week, Biophychrom is happening and there’s still time to join us! 👇🏻

lister fellowship applications invited!

lister-institute.org.uk/how-to-apply/

Thank you Nick! It was a great day at the John Innes and Sainsbury Labs with lots of interesting discussions

The nucleoid of rapidly growing Escherichia coli localizes close to the inner membrane and is organized by transcription, translation, and cell geometry - Nature Communications The mechanisms underlying bacterial chromosome configuration are not fully understood. Here, Spahn et al. show that the Escherichia coli nucleoid adopts a condensed, membrane-proximal configuration du...

I forgot to post about this recent paper - exciting work led by @michriscopy.bsky.social showing clearest evidence yet for transertion strongly tethering the bacterial nucleoid to the membrane during fast growth. It was a pleasure to contribute a little 🔬🦠🧫 www.nature.com/articles/s41...

Professor Bela Novak (1956–2025): A Life of Scientific Discovery in Numbers It is with profound sorrow that we announce the passing of Professor Béla Novák

An emotional day today @oxfordbiochemistry.bsky.social where leaders in the cell cycle field gathered to celebrate the life of Bela Novak and the huge impact he had on their work! www.bioch.ox.ac.uk/article/prof...