George Samantsidis

A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes Nature Communications - Mosquitoes are major vectors for the transmission of many serious pathogens. This study uses genome-wide CRISPR screens in the mosquito, Anopheles gambiae, to reveal new...

Pleased to share our recent work in collaboration with the
@perrimonlab.bsky.social in which we perform the first genome-wide CRISPR knockout screen in Anopheles to examine essential fitness genes and genes associated with clodronate liposome function
www.nature.com/articles/s41...

A genome-wide CRISPR knockout in a major malaria vector identifies genes important for fitness & immune-related processes @natcomms.nature.com @perrimonlab.bsky.social @iowastateu.bsky.social @harvardmed.bsky.social @georgesaman.bsky.social @vectorimmunity.bsky.social
www.nature.com/articles/s41...

To the insect folks — does anyone have experience with the World Precision Instruments injectors? Our new Nanoject III stopped working after the third use, and we’re now exploring other options, such as this one
www.wpi-europe.com/products/ani...
If you know anything about it, please drop a comment!

Sarah Merkling wants to "pasteurize" mosquitoes! At the Institut Pasteur, Sarah Merkling's research focuses on a topic that is still largely unknown: interactions between mosquitoes and viruses. She boldly devises novel strategies based on state-of-...

🦟 Can we "pasteurize" mosquitoes to stop dengue & Zika?

Sarah Merkling @merklinglab.bsky.social uses AI + CRISPR to analyze stomach cells and understand why some mosquitoes spread viruses while others don't.

Goal: Make disease-carrying mosquitoes harmless.
#Zika #Dengue

Tempted to uncover the secrets of mosquito microbiota? Join us! We're hiring! 👇

Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...

Out now!

Taxonomic expansion and reorganization of Flaviviridae

@vasilakislab.bsky.social @grovearmada.bsky.social & co

#microsky

www.nature.com/articles/s41...

A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito A comprehensive single-nucleus RNA-seq atlas of >367,000 nuclei from male and female Aedes aegypti mosquitoes reveals sexual dimorphism in sensory systems and brain cell types and widespread co-expres...

Excited to announce the final version of the Mosquito Cell Atlas is out now in @cellpress.bsky.social!! 🦟🩸

There is SO much left to find & investigate in this dataset (& the rich biology of the Aedes aegypti mosquito)! We hope this helps scientists in many fields!
www.cell.com/cell/fulltex...

It was about time to leave the old platform and join this one!
Excited to connect with old and new friends here 🧬✨
#vectorbiology #mosquitoes

Infectious bacteria, but not the microbiota, induce a NOX-ATM-cytokine pathway that controls epithelial turnover Nagy et al. identify a NOX-ATM-cytokine signaling axis in the Drosophila gut that is activated by infection independently of DNA damage. This pathway promotes enterocyte loss, cytokine production, and...

Our new study is out in Cell Reports!
We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...

TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae Author summary Mosquito innate immunity is a major determinant of vector competence with significant implications in malaria transmission. During infection with the Plasmodium parasite, mosquitoes mou...

Celebrating the holiday weekend with another bang! Our work describing roles of TNF signaling on mosquito immune cell function and in limiting malaria parasite infection is now published. Big shout out to @georgesaman.bsky.social and others for their contributions! journals.plos.org/plospathogen...