Jan Homolak

Unexpected side-effect: how common medications clear the way for pathogens

CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.

Press release: www.cmfi.uni-tuebingen.de/en/news-even...

Another fantastic study from @lisamaierlab.bsky.social showing how non-antibiotics impact gut ecosytem. Congratulations @ghammeranne.bsky.social et al.!

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...

Stephan Kamrad and Tara Davis in the Patil lab at the MRC Toxicology Unit have identified that some drugs and environmental contaminants alter gut bacterial amine metabolism.

Find out more here: buff.ly/5akzsgs
@kiranrpatil.bsky.social @skamrad.bsky.social

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

Gut bacteria to the rescue! 🦠✨
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...

🎓 Big milestone for our lab — our very first PhD is finished! Huge congratulations to @ghammeranne.bsky.social for an incredibly impressive piece of work. We are so proud of you and can’t wait to see what you’ll do next. 💫 #PhD #proudPI

What timing! 🎉 Lab member Julia’s first first-author paper got accepted just 8 minutes before her PhD defense started! Huge congrats on a successful PhD and an impressive defense! 🥳📚 #AcademicLife #PhDDefense #TimingIsEverything

Do people in the same household share strains when they have the same species?

How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?

We answer these and related questions for the facial skin microbiome in our latest paper.

🧵[1/10]

Thanks for sharing @drpaulwicks.bsky.social I think next time we also have to bring cheese! (-:

Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition Nature Communications - Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels,...

I am very excited to share our latest publication on the effect of systemic #endotoxin on intestinal #microbiota spearheaded by the brilliant Sanne Kroon at the Hardt lab @eth-dbiol.bsky.social @ethzurich.bsky.social @naturecomms.bsky.social

👉🏼 rdcu.be/eelLn

Brochado and Maier labs in Germany are looking for a PhD student to study horizontal gene transfer in bacteria. ENDAMR Marie Curie doctoral network (endamr.eu) - an amazing opportunity to work with top scientists in the field all around Europe!
www.cmfi.uni-tuebingen.de/mariecuriephd

SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.

OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome

@harriswang.bsky.social & co

www.nature.com/articles/s41...

Simulating 500 million years of evolution with a language model More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can gen...

www.science.org/doi/10.1126/...
Crazy

@skyview.social unroll

Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways - Nature Metabolism Castells-Nobau et al. provide insight into how bacteriophages in the gut microbiome contribute to regulating food addiction by modulating tryptophan and tyrosine metabolism in the host.

How intriguing and interesting! Here, authors suggest that Microviridae phages, particularly Gokushovirus WZ-2015a, are linked to obesity and food addiction variables in humans from multiple cohorts, with a direct suggested link to serotonin and dopamine metabolism.
www.nature.com/articles/s42...

So at the beginning of my postdoc I struggled to amplify Chlamy genes (easily 75%+ GC) and did pretty much the same comparison and found the same results

DMSO= helps but kills pol processivity
Betaine= Lots of spurious products
1,2-propandiol= processivity retained and usually specific product

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

This is figure 4, which shows collateral sensitivity and cross-resistance interactions between and within antibiotic classes.

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

I love the fact that Google+ is still here 🥲

Altmetric cumulative attention shown by day in the Altmetric Explorers. The Sky Blue section from Bluesky is growing over time.

The Rise of Skywalkers

Pulled together this starter pack for Microbiota-Gut-Brain Axis Research.
🧠🦠🥼

Hope it is helpful for the people joining in here and nucleating a community.

May have missed people, please leave a reply and I can then add to the pack.

Cheers.

go.bsky.app/PZhXP7R

Extensive impact of non-antibiotic drugs on human gut bacteria Nature - Some non-antibiotic drugs have been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Athanasios Typas and colleagues screened more than...

In a great collaboration with @typaslab.bsky.social, @lisamaierlab.bsky.social and @biocs.bsky.social found that 24% of the tested human-targeted drugs inhibit the growth of gut commensal bacteria.

"Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...

Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...

A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

Fish brains host microbes- could human brains host them too? I shared my "inherently skeptical", but intrigued, thoughts in this fun article.

A starter pack of starter packs!

‘That’s funny’: creative solutions for time-starved researchers An immunologist and his illustrator friend reveal tips and tricks to help scientists to reach peak performance and creativity.

"The cognitive switch between the attention to detail required to do lab work, so that you don’t lose track of whether you added the right reagent to the last of 96 identical wells, and the free-flowing dissociative state needed for creation is nigh on impossible."
www.nature.com/articles/d41...

💡💥Here’s a modest proposal I’ve been pondering for a while on how to change the PEER REVIEW process and start more community-driven SCIENCE FUNDING. Lots of feedback/discussion welcomed! Other variants of the idea might exist already—not claiming originality. (a long 🧵) (1/9)

Gut physiology and environment explain variations in human gut microbiome composition and metabolism - Nature Microbiology An observational longitudinal clinical trial, incorporating a SmartPill and metabolomics, reveals the role of host factors in shaping the gut microbiome in healthy human adults.

Today we publish an (in my opinion) important paper in
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...