Many thanks to Brian, Clayton and @sethblackshaw.bsky.social for the computational analysis, Caterina, Meghana and Ya-Wen for the samples, and @bobbyjeyeguy.bsky.social for the mentorship and support throughout the journey. Thrilled to see what discoveries lie ahead! 👀
Excited to share my PhD work! We characterize waves of cell death during human retinal development, and show how blocking apoptosis promotes RGC long-term survival and alters their developmental dynamics in organoids. These findings will improve future organoid design for retinal disease modeling‼️
Our latest preprint is out, focusing on characterizing the response of Lhx6-positive neurons of the zona incerta (ZI) to naturally-occurring and experimentally-induced changes in the need to sleep, also known as sleep pressure.
www.biorxiv.org/content/10.1...
Check out this tour de force work from @christ3na.bsky.social in my lab!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
Happy for this paper to be out on direct circadian-independent effects of light on glucose and lipid metabolism. Spearheaded by student, Xiangning Chen, and in collaboration with Haiqing Zhao and @samerhattar.bsky.social
www.science.org/doi/10.1126/...
Wrapping up my first CSHL meeting #CSHL2024Brain ! Had a great time discussing and learning a lot from this welcoming and inspiring community💡Many thanks to organizers @sergiuppasca.bsky.social and Dr. Guo-li Ming for making this meeting fruitful and enjoyable to all attendees, especially trainees!
Heading out of town for the 2024 #cshlbrain meeting at Cold Spring Harbor Laboratory and ready to dive into the fascinating world of brain organoids!
