Madelon de Jong

Terrific work from @jelenalab.bsky.social and Fabian Fischer on controlling cell death. Fantastic to see this out!

I love me some Bernie Sanders

He is evil

Super proud of my friend Sabrin @sabtahri.bsky.social, whose final (and terrific) PhD work came out today in #Blood (in collab with group of Niels vd Donk)

It demonstrates an association between BM CD16+ NK cells and response to dara!

#hemesky #hematology #myeloma

doi.org/10.1182/bloo...

And your annual reminder that one billion is a THOUSAND million. And most of these people have multiple billions (because investments are incremental). No one ever needs that kind of money. The homeless person on the street could do with some housing though.

Reese Witherspoon became a billionaire and people are cheering and congratulating her on being a hugely talented business woman.

I feel people do not realise that money is a limited thing. Billionaires (skilled or not, it doesn’t matter) are hoarding the resource.

What I find so brilliant about the haematopoiesis is that it takes place in a piece of tissue (bone) that already fulfils another role (holding up the meat sack).

Human design being space-efficient, ain’t it something

Disgusting

What the hell???

It’s one of the frustrating things about bsky still, posts don’t seem to get the engagement that they used to get on Twitter

When I said 2025 was gonna be my year 😭 Can I restart? I wasn’t ready

Just learned that US school libraries have banned Anne Frank’s diary, for the reason being she briefly discusses crushing on a girl.

Anne Frank’s diary! Banned!

This isn’t my data but I’m seeing something similar

Hematologists! I need help!

What is the unmarked population? Lin-cKit+Sca1-CD16/32+CD34- in mouse bone marrow!

#hematology #hemesky

Getting a bit tired of the inflation of importance of the physician-scientist. And I say that as someone who went to med school once upon a time.

Acting like they’re the most important being in research sells basic biologists, far stronger in bench lab skills, way short.

I’m jealous!! Enjoy the warmth!

Landed my 2nd ever grant, hurray! 🥳

Eurostar really getting on my last nerve and it’s only Jan 5th

Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

For anyone who may need these over Xmas…just in case

Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA

Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...

Woop woop!!! Congrats Sanne 👌🏼

Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma Malignant plasma cells in multiple myeloma patients reside in the bone marrow and continuously interact with local immune cells. Progression and therapy response are influenced by this immune environ...

Now in press, excellent paper by @zkellermayer.bsky.social where he shows that in the myeloma 5TGM1 model activation of NK cells, ILC1 and CD8+ T cells is lost upon disease progression! 👀

Awesome work, happy to have contributed #mmsm

onlinelibrary.wiley.com/doi/full/10....

Things to love about living in Oxford:

Hahaha bless you, all good!!

What if all PhDs just stopped defending and started attacking?

Cuuute! Enjoy

💕

Thanks Matthew! Hope you had a fantastic time last week yourself!