Simon Cleary

This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨

Ok pals. Looking to move all my teaching materials open and online, and am developing new modules that I want to start off this way. Content = reading, quizzes, videos, and code tutorials. Opinions on the best platform? Good examples of best practice I can steal from? Many thanks.

Few but mighty - check out this cool study implicating gamma delta T cells in controlling macrophage responses in lung cancer!

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

When vessel constriction fails: Cellular mechanics linking developmental remodeling to vascular malformations

Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating
how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM.
www.bdr.riken.jp/en/news/rese...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com
www.nature.com/articles/s41...

www.biorxiv.org/content/10.6...

Excited to share our new preprint: Not all microglia are the same. In this study, we identify a specialized ApoE-dependent program in the median eminence positioning microglial lipid metabolism as a driver of hypothalamic adaptation to nutritional stress.

I am looking for an Illustrator to help with making schematics and diagrams.

Might anyone guide me on who to contact?

Thanks

#science #Illustration #Academia

Cool to see data backing up an anecdote I have been told - that short (1 hour) formaldehyde fixation can be better than longer (6 hours+) fixation for staining some antigens:

Anyone ever tried super glue (cyanoacrylate) for mounting coverslips with stained mammalian cells, to be used for fluorescence microscopy?
I'm looking for ways to conserve microscopy samples for a looooooong time...

On the balance of knowledge - Nature Reviews Immunology Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...

Useful article addressing an often-overlooked way in which research impacts the environment:

Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough This randomized clinical trial examines the safety and efficacy of oral nalbuphine in patients with chronic cough caused by idiopathic pulmonary fibrosis.

Good news!! Oral Nalbuphine reduces cough count baseline by ~50 % in Idiopathic Pulmonary Fibrosis–Associated Cough jamanetwork.com/journals/jam...

Nice evidence for a role for the ectonucleotidase CD39 in limiting pulmonary thromboembolism in sickle cell disease with striking footage of this process!

"Does this handle survival plots too?" asked @load-dependent.bsky.social

Yes it does! See below for RECOVERY.

Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).

Thanks, odd decisions being made at a company with a focus on preventing plagiarism.

Can you link to more information on this?

Tumor-draining Lymph nodes - Online event next week!
follow the link to register

On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer:

events.cancer.gov/dcb/tdln #TLDNForums

Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!

This is cool stuff - imaging covalent drug biodistribution using tissue clearing methods

I am reminded of @charlottesummers.bsky.social presenting images taken on gamma scanners made from pre-war steel, the only steel free from contamination with fallout from nuclear weapons tests...

Please check out our job post @biologists.bsky.social!

We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens!

bit.ly/3La9idq

Enjoyed learning about the importance of Batf3 for IL-17-producing γδ T cell responses that protect neonates during influenza infection! Congrats Pedro and colleagues!

Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.

www.cam.ac.uk/jobs/assista...

Love these 3D renderings of the extracellular matrix cages surrounding megakaryocytes!

bsky.app/profile/wcla...

Fun revisiting this study and looking at the eLife peer review system for this postLight:

Heading to BSI congress? Plan on attending this all-star session, Thursday at 11AM, chaired by @doreenlau.bsky.social and me!

Doctoral INPhINIT fellowships - Incoming Call 2026 We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.

Outstanding PhD fellowship call OPEN for excellent students.

lacaixafoundation.org/en/doctoral-...

This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).

If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!

Looking forward to chairing a session with @doreenlau.bsky.social at the British Society for Immunology Congress next week!

Great line-up of speakers. Send an email if you would like to meet at or around the conference.