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Yi-Wei Chang

@yiweichang

Assistant Professor of Biochemistry and Biophysics, University of Pennsylvania https://www.yiweichanglab.org/ Structural biology; cryo-electron tomography; host-pathogen interactions

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14.11.2024
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Latest posts by Yi-Wei Chang @yiweichang

Congratulations to Melanie Ohi for this very well-deserved recognition!

11.12.2025 14:30 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!

15.05.2025 19:51 πŸ‘ 30 πŸ” 9 πŸ’¬ 1 πŸ“Œ 2
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Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

15.05.2025 19:51 πŸ‘ 122 πŸ” 56 πŸ’¬ 7 πŸ“Œ 3

Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧡(1/n)

02.04.2025 13:02 πŸ‘ 97 πŸ” 26 πŸ’¬ 10 πŸ“Œ 3

Exciting update on the CryoET Data Portal! A new annotation set from Mart Last & team is now live. They’ve doubled available annotations with >1,800 tomograms of Chlamydomonas reinhardtii which now have almost fully dense labels, and all can be visualized in the browser using Neuroglancer.

23.01.2025 20:48 πŸ‘ 41 πŸ” 15 πŸ’¬ 1 πŸ“Œ 0

Thrilled to share that our work with the Ben Black Lab, led by a co-mentored star MD/PhD student Katie Kixmoeller, now is formally published! We used cryo-ET to study kinetochore features in human mitotic chromosomes. πŸ§¬πŸ”¬β„οΈ

23.01.2025 18:47 πŸ‘ 9 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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🦟🌍 Join us for the 21st edition of #EMBLMalaria as we strengthen partnerships, share insights, and drive innovations to combat malaria's toll and advance global health.

πŸ“… 20 – 22 May 2025
πŸ“ EMBL Heidelberg and Virtual
πŸ“ Submit abstract by 25 Feb

πŸ‘‰πŸ» s.embl.org/bmp25-01-bl

#malaria #epidemiology

16.12.2024 13:14 πŸ‘ 10 πŸ” 8 πŸ’¬ 0 πŸ“Œ 2