At the center of every nuclear pore lies a mystery. Here, clumps of proteins wiggle disordered tails around like seaweed. How do they drive a molecular machine that moves so many molecules in and out of the nucleus efficiently, with little room for error? www.quantamagazine.org/disorder-dri...
Happy to share our work on conventional and time-resolved cryo-EM studies of NTSR1, now published in Nature!
nature.com/articles/s41...
Wonderful collab. w/ Sumino, Mitsutake, Kobilka, & Inoue labs.
Congrats to Kazuhiro, Kouki, Toshiki, Shun & everyone involved!
Excited to share our work is out in
@Nature
! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins.
www.nature.com/articles/s41...
Invited Session MAR-M01. How Early-Career Physicists Are Solving Society's Greatest Challenges. Wednesday, March 18, 12:00 — 3:00 p.m. Convention Center, Bellco Theatre 1-2
Next week I am going to be in Denver for the American Physical Society Global Physics Summit.
#APSsummit26
Come and see my talk in the early-career session:
summit.aps.org/events/MAR-M01
Reach out if you would like to connect or catch up with me there!
@standupforscience.bsky.social
Earlier today at City Hall Park.
#StandUpForScience #SUFS #NewYorkCity #NYC
Chinese High Speed Rail built since 2008, overlayed on the USA and Canada. There's a legend in the lower right showing lines capable of various speeds. Most of the mapping is on the east coast of the US, equivalent to the dense urban centers of eastern China.
If the US & Canada had been building high-speed rail at the same rate as China since 2008, you could travel from Toronto to DC in <4 hrs for about $80.
They've built ~50,000 km (31,000 miles) as of 2025.
Some lines operate at 350 km/h (217 mph) with increased speeds planned.
(🧑🎨: colinstalter)
"What is temperature at the microscopic level?" A person answers, "Molecular kinetic energy!" His irate, glowing-eyed boss then throws him out the window of a tall building.
I have found that many people don't know about configurational temperature, so I wrote a short note about it on my website.
www.samuelfoley.com/misc/
Blizzard at Harvard last week.
#Blizzard #Snow #Winter #Weather #Harvard #Massachusetts #Photography
Promotional graphic with ball and stick representation of CSD Entry URUQUX, a Diboraanthracene scaffold.
The latest Cambridge Structural Database (CSD) update adds 21,282 new crystal structures (22,897 entries) to support crystallography research across pharmaceuticals, agrochemicals, materials science, and related fields.
👀More at ccdc-info.com/4u1VkMe
#Crystallography #CompChemSky
"Gistradagis" is a Gothic word, attested once, that perfectly corresponds to English 'yesterday' – except that it means 'tomorrow'.
Old Norse is flexible with this word too ('í gær' means 'yesterday/tomorrow'), perhaps due to a common stage when it came to refer to a day on either side of today.
Thank you!
Fishers at the Prospect Park Lake.
#Brooklyn #Winter #Photography
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
A display of the grave goods, featuring a he chainmail shirt, a helmet on a stand, a long sword, small gold ornaments, and various metal, glass, and ceramic objects, all arranged against a dark background.
The early medieval burial from Gammertingen, 6th century AD.
The high-ranking warrior died in his early 30s and was buried with a Byzantine helmet (a so-called Spangenhelm), his weapons, and his mail armour, which consisted of about 45,000 iron rings!
📷Landesmuseum Württemberg
🏺
Cute café in my neighborhood.
#PLG #Flatbush #Brooklyn #NewYork #Photography
View of Boston over the frozen Charles River from Cambridge.
#Boston #Cambridge #Winter #Ice #Massachusetts #Photography
Boston last night vs. Boston this morning.
#Blizzard #Boston #Photography
Ready to TANGO? 💃 In our new publication, Beata Turoňová & Markus Schreiber (@ms314.bsky.social, @becklab.bsky.social) present TANGO: the first cryoET framework to analyze the relation between particle positions and orientations 🪩 All in a single user-friendly package! #CryoET #OpenScience
“Success in US science has come from sustained funding and welcoming the best talent from around the world, yet both of these advantages are in decline”
www.science.org/doi/10.1126/...
I'm officially a godfather now.
Coming from Europe, almost every business interaction in the U.S. has felt like a scam.
Glad to see that I'm not crazy.
www.theatlantic.com/ideas/2026/0...
Visiting my hometown.
#Binzwangen #Germany #Photography
Times Square, November 2022
#Photography #NYC #NewYork #StreetPhotography
Do you remember when people were saying "I think my phone is listening to me, i'm getting ads for stuff I spoke about" and people said "They arent listening to you, they're just this good at predicting your interests"?
Well, it happens they were doing exactly that.
www.cbsnews.com/news/google-...
I genuinely have no idea how to convey this to the American people, but I think the biggest impediment to any kind of immigration reform is that people are convinced that "legal" and "illegal" are immutable, intrinsic categories instead of a rapidly-shifting arbitrary constellation of regulations.
