Nandan Gokhale

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech.
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...

Explainer 1/8

Wonderful opportunity. Go join Emmanuelle’s lab!

I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com

Exogenous RNA surveillance by proton-sensing TRIM25 Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

Last Saturday morning ☕ saved for this gem:

www.science.org/doi/10.1126/...

CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.

Congrats to Julian and others from @ramlabuw.bsky.social on this cool work that finds that the loss of the RNA-binding protein CELF2 leads to accumulation of endogenous RIG-I ligands! #RNA #innateimmunity #IFNs

Chicken Soup for the Scientist's Soul

Really cool work from @thehornerlab.bsky.social and colleagues highlighting a role for the UFMylation post-translational modification system in flavivirus viral particle production!

Reposting my offer for 1-1 mentoring for anyone… email me and we'll find a time! Especially happy to talk with those from diverse backgrounds and non-traditional career trajectories.

We have an open faculty search for TWO positions in microbiology and virology at the University of Illinois! We have world class core facilities and a fantastic collaborative group of young faculty...you could be next!
Please re-post/skeet!

Thanks Alex!

Yes! I'm wondering the same thing :D

Thanks Dave!!!

Thanks Sunny!

Thank you Marco!

I am so excited to join the faculty in the Division of Immunobiology at Cincinnati Children's Hospital Medical Center in March 2025. My lab will study how RNA biology regulates and is regulated by infection and immunity.

We'll be hiring at all levels in 2025 - stay tuned!

www.gokhalelab.com

Cellular RNAs directly regulate the activity of an antiviral immune signaling complex
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @nandangokhale.bsky.social @ramlabuw.bsky.social

This Perspective by Sonja Best and Adam Hage puts tuning the MAVS signalosome by cellular mRNAs into context.

buff.ly/4fxVMcx

#Immunology @science.org

#Immunology out now @science.org

An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.

https://buff.ly/4grnf18

By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.

Platform influencers—host RNA control of antiviral immunity Cellular RNAs directly regulate the activity of an antiviral immune signaling complex

We are grateful for this perspective on our work authored by Sonja Best and Adam Hage

www.science.org/doi/10.1126/...

Here’s a tweetorial/BSorial? of the preprint that highlights our key findings

bsky.app/profile/nand...

Cellular RNA interacts with MAVS to promote antiviral signaling Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology

@ramlabuw.bsky.social

www.science.org/doi/10.1126/...

Will email you to set up a locus!

Do you have any spare ploidy this month? Would love to take you to lunch/coffee/drinks as a thank you!

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

Time for our first post here 🥳 Our latest paper is online 🙌
We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

Really interesting work by Rachel van Gelder and the @ramlabuw.bsky.social lab! #RNA #immunity

CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.

#omap4lyfe. We've had a great experience using this protocol-- five stars, highly recommend. @pspeck-enthusiast.bsky.social

O-MAP is a gift that will keep on giving!

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...

Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...