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Andy Kempchinsky

@ampersandy

PhD Student at UZH/USZ๐Ÿ‡จ๐Ÿ‡ญ Focusing on visualising microbes to understand spatial host-microbe interactions. More microbiologist than your average engineer; more engineer than your average microbiologist. Bad at both! ๐Ÿณ๏ธโ€๐ŸŒˆ

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29.09.2023
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Latest posts by Andy Kempchinsky @ampersandy

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The landscape of microbial associations in human cancer Differences between cancer types, infectious disease, and potential prognostic markers are uncovered by studying microbes within cancer DNA.

The landscape of microbial associations in human cancer www.science.org/doi/10.1126/...

TLDR -- most cancers do not have microbiomes...but a few do have consistent microbe associations (i.e., colorectal and oral cancers). Make sense!

12.09.2025 19:40 ๐Ÿ‘ 64 ๐Ÿ” 27 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 3
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New Apple study challenges whether AI models truly โ€œreasonโ€ through problems Puzzle-based experiments reveal limitations of simulated reasoning, but others dispute findings.

The results seem to strengthen the case that these systems rely on elaborate pattern-matching rather than the kind of systematic reasoning their marketing might suggest.

13.06.2025 17:02 ๐Ÿ‘ 205 ๐Ÿ” 71 ๐Ÿ’ฌ 12 ๐Ÿ“Œ 14
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PBEEE/Quebec Merit Scholarship for Foreign Postdocs and Visiting Research Student and Visiting Researchers **Note that the FRQ is in the process of revamping their webpages. We will update links soon as we can with the current 2025 year's information. Be sure to check back to see if any eligibility or docu...

Are you a recent PhD (or soon to be PhD) from outside Canada looking to do a postdoc in Quebec?

Get in touch if you are excited about microbes, evolution, ecology, genomics (or all of the above!) and I'd be happy to help develop a project together!

www.mcgill.ca/gps/funding/...

11.06.2025 19:00 ๐Ÿ‘ 50 ๐Ÿ” 67 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 4
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A visualโ€“omics foundation model to bridge histopathology with spatial transcriptomics - Nature Methods OmiCLIP is a visualโ€“omics foundation model that integrates histology and spatial transcriptomics. The associated Loki platform offers accurate and robust tools for alignment, annotation, cell-type dec...

Fascinating! Will read the moment Markie stops purring my lap
#caturday
#WorkLifeBalance
www.nature.com/articles/s41...

08.06.2025 15:35 ๐Ÿ‘ 5 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Trump team pauses new student visa interviews as it weighs expanding social media vetting Itโ€™s the latest salvo against universities, many of whom rely heavily on foreign students for funds.

The Republican administration has halted all student (and postdoc etc) VISA interviews.

I've written a lot about soft power here. The attacks on foreign students in the US not only undercuts the funding stream for US universities; they hemorrhage US soft power.

27.05.2025 19:09 ๐Ÿ‘ 212 ๐Ÿ” 59 ๐Ÿ’ฌ 12 ๐Ÿ“Œ 2
Bioengineering needs diversity - Nature Reviews Bioengineering Policies that limit diversity and inclusion undermine evidence-based science by creating gaps in the data, potentially distorting findings and skewing results. When diversity and inclusion are sidelin...

www.nature.com/articles/s44...

20.05.2025 07:32 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Risk of cancer in people with HIV experiencing varying degrees of immune recovery with sustained virological suppression on antiretroviral treatment for more than 2 years: an international, multicentre, observational cohort The impact of long-term virological suppression and CD4 count recovery on non-AIDS defining cancers (NADC) is unclear.

Risk of cancer in people with HIV experiencing varying degrees of immune recovery with sustained virological suppression on antiretroviral treatment for more than 2 years: an international, multicentre, observational cohort

โœ… Just Accepted
โญ Editor's Choice
#IDSky

16.05.2025 18:58 ๐Ÿ‘ 2 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Emergence of transferable daptomycin resistance in Gram-positive bacteria - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - Emergence of transferable daptomycin resistance in Gram-positive bacteria

This is fascinating, but also terrible news regarding antimicrobial resistance in multidrug-resistant Gram-positives

'Emergence of transferable daptomycin resistance in Gram-positive bacteria'

www.nature.com/articles/s44...

29.04.2025 09:53 ๐Ÿ‘ 46 ๐Ÿ” 18 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 1
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๐Ÿ“ข SBMI 2025
Join us at the 8th International Symposium "Systems Biology of Microbial Infection", Sept 18โ€“19, 2025 in Jena

Submit your abstract & consider applying for a Tandem-Talk!

Info & speakers: asb-conference.hki-jena.de

#SystemsBiology #InfectionBiology #BioimageAnalysisTools

15.04.2025 12:03 ๐Ÿ‘ 20 ๐Ÿ” 9 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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CHECK IT OUT ๐Ÿฆ ๐Ÿ‘€

Very cool article by science journalist Carrie Arnold reviewing recent research from leading laboratories on how the unique shape of a microbial #biofilm emerges from interactions of its component microbes with each other and their environment

www.quantamagazine.org/how-a-biofil...

21.04.2025 18:30 ๐Ÿ‘ 82 ๐Ÿ” 20 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 0

Often in English people confused definitely and defiantly, which gives some of their statements a strong rebelliousness.
โ€œI will defiantly finish reading this book today.โ€

In German I can never remember if itโ€™s lebe or liebe. So I often say, โ€œIch liebe in Zรผrichโ€, which is poetic as hell.

22.04.2025 08:17 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

www.nature.com/articles/s41...

26.03.2025 18:06 ๐Ÿ‘ 39 ๐Ÿ” 16 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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Emergence and global spread of a dominant multidrug-resistant clade within Acinetobacter baumannii - Nature Communications In this study, authors conduct a genomic analysis of 15,000 Acinetobacter baumannii isolates, revealing a dominant multidrug-resistant super-lineage (accounting for approximately 70% global isolates),...

New work showing that multidrug-resistant ๐˜ˆ๐˜ค๐˜ช๐˜ฏ๐˜ฆ๐˜ต๐˜ฐ๐˜ฃ๐˜ข๐˜ค๐˜ต๐˜ฆ๐˜ณ ๐˜ฃ๐˜ข๐˜ถ๐˜ฎ๐˜ข๐˜ฏ๐˜ฏ๐˜ช๐˜ช isnโ€™t a scattered threatโ€”itโ€™s a structured epidemic!

A dominant super-lineage and a rising clade (2.5.6) are spreading worldwide, fueled by gene exchange.

Li et al. Nat Commun
#AMR #bacterialgenomics

www.nature.com/articles/s41...

23.03.2025 14:36 ๐Ÿ‘ 11 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Information storage across a microbial community using universal RNA barcoding - Nature Biotechnology Barcoding microbial ribosomal RNA creates a recording of gene transfer events without requiring translation.

Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with James Chappell & @joffsilberg.bsky.social and incredible students. www.nature.com/articles/s41...

18.03.2025 15:56 ๐Ÿ‘ 74 ๐Ÿ” 32 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 3
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Join us on Friday, March 21 @ 13:00 CET for the #Virtual Pub with Alexander Morrell, Kingโ€™s College London, @bioimaginguk.bsky.social. He'll give an exciting talk on "Metallomics Imaging: Unlocking Elemental Insights into Human Health & Disease."
Register๐Ÿ”ฝ
www.eurobioimaging.eu/events/metal...

20.03.2025 14:19 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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A computational pipeline for spatial mechano-transcriptomics - Nature Methods The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

๐Ÿšจ Paper Alert ๐Ÿšจ
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods๐Ÿ‘‡!!
www.nature.com/articles/s41...

17.03.2025 12:52 ๐Ÿ‘ 139 ๐Ÿ” 53 ๐Ÿ’ฌ 10 ๐Ÿ“Œ 3
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The American Society for Microbiology (ASM) is a great example of an organization that is supposed to stand up for science and scientists, but is completely spineless.

They're kowtowing to pressure from the Admin, refusing to stand up at one of the most critical times in U.S. science.

Compare๐Ÿ‘‡

09.03.2025 19:19 ๐Ÿ‘ 162 ๐Ÿ” 52 ๐Ÿ’ฌ 8 ๐Ÿ“Œ 6

Patient partners play a vital role in research but face systemic barriers to fair pay. Institutions must match their equity commitments with actionโ€”transparent, equitable compensation is long overdue.

03.03.2025 06:23 ๐Ÿ‘ 16 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses Nature - Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the...

Macrophages are just the tireless workhorses of the immune system.... #ImmunoSky ๐Ÿงช

www.nature.com/artic...

28.02.2025 08:12 ๐Ÿ‘ 9 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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ISME supports students and postdocs to further develop their academic knowledge and skills in a host institution outside of their country of study. Submit your application by 31 March 2025.
๐Ÿ”—https://isme-microbes.org/isme-scholar-mobility-fund-call-for-applications/
#MicrobialEcology #microbes

25.02.2025 16:42 ๐Ÿ‘ 19 ๐Ÿ” 20 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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Cooperative nutrient scavenging is an evolutionary advantage in cancer - Nature Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

Tumor cells help each other out when amino acids are scarce www.nature.com/articles/s41...

23.02.2025 10:18 ๐Ÿ‘ 18 ๐Ÿ” 9 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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โ€˜The Interviewโ€™: Ed Yong Wants to Show You the Hidden Reality of the World The Pulitzer Prize-winning science writer talks about burnout from covering the pandemic and how bird-watching gave him a new sense of hope.

The most achingly beautiful explanation of what science is, from @edyong209.bsky.social: โ€œthe idea that much of the world is hidden from us, that we donโ€™t perceive it and donโ€™t understand it, and that it is worth understanding and it is necessary to understand.โ€

www.nytimes.com/2025/02/22/m...

22.02.2025 15:46 ๐Ÿ‘ 465 ๐Ÿ” 129 ๐Ÿ’ฌ 9 ๐Ÿ“Œ 15

It's hard to express how cool this work is, so I'll just say that if you crave beautiful experiments and rigorously done theory to match, @fernpizza.bsky.social is your guy. Go read this amazing paper right now!

22.02.2025 12:12 ๐Ÿ‘ 5 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Has anyone ever hosted a Wiki-write in?

19.02.2025 12:29 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email (klangin@aaas.org) or on Signal. We can guarantee annonymity.

14.02.2025 20:05 ๐Ÿ‘ 2470 ๐Ÿ” 1299 ๐Ÿ’ฌ 24 ๐Ÿ“Œ 15
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Indonesia launches groundbreaking national AMR survey on bloodstream infections In November 2024 through January 2025 the Indonesian Ministry of Health (MoH) and World Health Organization (WHO) launched the countryโ€™s first national survey to tackle antimicrobial resistance (AMR) ...

Indonesia and WHO launched a national survey on AMR in bloodstream infections, targeting 10,000 patients to improve treatment and policy. This initiative strengthens surveillance, laboratory capacity, and hospital preparedness to combat AMR. #AMR #GlobalHealth

www.who.int/indonesia/ne...

13.02.2025 05:34 ๐Ÿ‘ 36 ๐Ÿ” 9 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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Imaging of cellular dynamics from a whole organism to subcellular scale with self-driving, multiscale microscopy - Nature Methods A self-driving multiresolution light-sheet microscope enables the simultaneous observation and quantification of cellular and subcellular dynamics in the context of intact and developing organisms ove...

I have seen lots of flavors of smart/event-driven microscopy, and this builds directly on the shoulders of existing works, but also takes this idea an important step further, both conceptually and in terms of accomplishments. www.nature.com/articles/s41...

13.02.2025 22:02 ๐Ÿ‘ 27 ๐Ÿ” 4 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

We really just take turns presenting in lab meeting and itโ€™s just an adult form of โ€œshow & tellโ€

12.02.2025 14:40 ๐Ÿ‘ 8 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Academics: Jevin and I would love to see this course used broadly around the world. Would you recommend publishing some sort of journal article about the course? (We don't need the publication for our CVs, but just want to get the word out.) If so, where would you target it?

Other promotion ideas?

09.02.2025 08:15 ๐Ÿ‘ 149 ๐Ÿ” 34 ๐Ÿ’ฌ 18 ๐Ÿ“Œ 2

For every dollar of federal research funding in the United States, universities generate between $2.30 and $3.00 of economy activity, much of that in local communities.

That doesnโ€™t even include the return on investment of getting a college or graduate degree, which research also dollars support.

08.02.2025 19:32 ๐Ÿ‘ 474 ๐Ÿ” 140 ๐Ÿ’ฌ 6 ๐Ÿ“Œ 8