Attention-like regulation of theta sweeps in the brain's spatial navigation circuit
Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion β without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)
The hippocampal map has its own attentional control signal!
Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See πΉ in post 4/6 and preprint here π
www.biorxiv.org/content/10.6...
π§΅(1/6)
28.01.2026 10:03
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Lab Website
π¨ Want to research the computational & neural mechanisms of planning and its disruption in mental health? If so, join our lab!
Here's one prestigious postdoc fellowship that just opened: azrielifoundation.org/azrieli-fell...
reach out w/your CV to paul.sharp@biu.ac.il
lab: sharplabbiu.github.io
02.09.2025 14:45
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Mapping the anatomy of placebo analgesia
The identification of somatotopy in brainstem pain modulatory pathways could help treat chronic pain
Thanks to @massih.bsky.social for inviting me to co-author this commentary @science.org Mapping the anatomy of placebo analgesia | Science www.science.org/doi/10.1126/...
28.08.2025 23:18
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Many thanks to my PhD supervisor, @shaharnitzan.bsky.social, and to our collaborators Rani Moran, Maayan Pereg and Roy Luria for their invaluable contributions.
Read the preprint here:
osf.io/preprints/ps...
02.09.2025 12:31
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On a practical note, some of what appears to be βrandom explorationβ could be explained by modeling humans associating rewards with random noise in the task.
02.09.2025 12:31
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Do humans automatically assign credit to all task-relevant (but outcome-irrelevant) features?
Does outcome-irrelevant learning persist even when the cost of it goes up?
Do high working memory individuals encode irrelevant values but inhibit them from influencing choices, or ignore them altogether?
02.09.2025 12:31
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Computational modeling shows that outcome-irrelevant learning is quite reliable across sessions, yet not everyone does this equally. Working memory capacity strongly predicts outcome-irrelevant learning. Suggesting working memory is central for maintaining a causal structure guiding learning.
02.09.2025 12:31
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To examine the possibility that participants are not convinced by the instructions, in Experiment 2, we gave 600 trials across three days, allowing them to infer that locations should be neglected. But, we find they keep assigning credit to outcome-irrelevant locations.
02.09.2025 12:31
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So we created a βmagical forestβ narrative, telling participants that the offered leaves are randomly driven to their locations by the wind. We find participants still show outcome-irrelevant learning, leading them to choose suboptimally and win a smaller money bonus.
02.09.2025 12:31
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Experiment 1 (N=504) was aimed at ensuring people truly understand the causal structure of the task. Previously, it was suggested that such credit assignment is due to participants forming a wrong model of the task, rather than due to an automatic model-free credit assignment.
02.09.2025 12:31
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We asked participants to choose cards to win rewards. Some cards had higher chances of winning than others, but the card locations on the screen were completely irrelevant. No matter how hard we tried, people still assigned value to locations.
02.09.2025 12:31
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Excited to share our new preprint! π¨
Does human learning have an automatic aspect? Is it possible that we learn things that are counterproductive and only lead to reduced gains?
02.09.2025 12:31
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Excited to be in #NeurIPS2024
Visit my poster at the Behavioral ML workshop or just come say Hi
openreview.net/forum?id=JAD...
10.12.2024 16:32
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I was fucking joking!
25.11.2024 13:30
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