BaumjohannLab

Looking forward to two exciting talks by
Jens Geginat (Milan) and Ralf Schmidt (Vienna) in the @efis-immunology.bsky.social EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET. Details: www.t-cells.eu

Tissue and Spatial Immunology | Keystone Symposia Join us at the Keystone Symposia on Tissue and Spatial Immunology, February 2027, in Banff, with field leaders!

Excited to organize @keystoneSymposia.bsky.social Tissue and Spatial Immunology with @leilaakkari.bsky.social and Hai Qi in February 2027! Join us to explore emerging research in Banff! keysym.us/KSSpatialImmune27 #KSSpatialImmune27

Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, a...

Our workflow to image and analyse germinal centres using a 50-plex cyclic staining protocol now out. Work led by Isabel San Martín Molina & Edith Marcial Juárez with @babrahaminst.bsky.social imaging facility scientists Simon Walker & Hanneke Okkenhaug.
onlinelibrary.wiley.com/doi/10.1002/...

Ever wondered what happens if you remove Tfh cells from established germinal centres?

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...

Finally, my PhD project is published! 🎉

I am thankful to all the collaborators who made this possible!

www.nature.com/articles/s41...

@natcomms.nature.com
#dendriticcells #immunesynapse #centrosome

Looking forward to two exciting talks by @carovinuesa.bsky.social and Dirk Elewaut in the EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET t-cells.eu

@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social

🚀 New preprint!
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...

🎉 The new yEFIS website is now live! 🌐

We’re happy to share that our new website is officially online, check it out 👉https://www.yefis.org/

@biorxivpreprint.bsky.social Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...

The Cluster Science Days 2025 were a very joyful event bringing together our Bonn scientists to share ideas and to network.

During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.

@natrevimmunol.nature.com Guidelines for T cell nomenclature
www.nature.com/articles/s41...

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

Registration is open for the Spring School on Immunology, hosted by DGfI
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social

Engineering and biofabrication of early cancer models Nature Reviews Bioengineering, Published online: 03 November 2025; doi:10.1038/s44222-025-00371-wEarly cancer biology and detection research is limited owing to a lack of clinical samples from pre-malignant and early-stage tumours. This Review discusses engineered in vitro systems that mimic early disease stages to investigate tumour progression and identify biomarkers for early cancer detection.

ICYMI: Engineering and biofabrication of early cancer models

@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social

CD8 T cells produce IFNg and CXCL13 in TLS

What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.

www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪

Junior Group Leader for RNA-Biology, RNA-Technology or RNA-Medicine (f/m/d) - Würzburg (Stadt), Bayern (DE) job with Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) | 12844907 #RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.:   089/2025 Starting date:                  As soon as possible. The con...

🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...

Arai, Kawakami, Sakaguchi (2025 #Nobel laureate) and colleagues show that oral antigen exposure combined with CD28 costimulation blockade generates functionally stable antigen-specific CD101⁺ pTreg cells even in previously antigen-sensitized hosts. rupress.org/jem/article/...

E15 Groups The Helmholtz Institute for RNA-based Infection Researchopens a call for

Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...

Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...

Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...

Job announcement: The image has a solid dark blue background with a clean, minimal layout. In the top left corner, the word “JOBS” appears in all-capital red sans-serif text. Below, large white sans-serif text spans several lines and reads: “Three Independent Group Leaders in Bioengineering Approaches to Human Health m/f/d.” Near the bottom left, smaller white sans-serif text reads: “Apply by November 16, 2025,” followed by “Max Delbrück Center (Berlin-Buch)” in lighter gray. In the bottom right corner is the Max Delbrück Center logo in white and blue.

🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.

Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.

👉 Apply now: www.mdc-berlin.de/career/jobs/...

Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available

Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go

(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

The official website of the Nobel Prize - NobelPrize.org The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for the purpose of engaging, inspiring and spreading knowledge about the Nobel Prize as well as the discoveries and achievements of the laureates.

The Nobel Assembly at Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to:

Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi

“for their discoveries concerning peripheral immune tolerance”

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...