Yiliang Ding

Me at the Blavatnik Awards, with my fellow finalists and giving me lecture

It was a wonderful experience to receive my Blavatnik Awards in the UK Finalist medal in the gorgeous Banqueting House this week!

Then give a public lecture at the Royal Society of Medicine!

A giant thank you to the Blavatnik Family Foundation and the The New York Academy of Sciences

Laboratory Technician (Ding Group) | John Innes Centre An exciting opportunity has arisen for a Laboratory Technician to join the Cell & Developmental Biology Department, to support the cutting-edge science of the John Innes Centre.

VACANCY - We’re looking for a Laboratory Technician to join the @yiliangding.bsky.social group, investigating the role of #RNA structure in the post-transcriptional regulation of gene expression.

www.jic.ac.uk/vacancies/la...

Closing date - 17 March
Contract - 36 months, Full-time

Evolution of error correction through a need for speed Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...

@science.org Evolution of error correction through a need for speed | Science #evolution 🧬🔬 www.science.org/doi/10.1126/...

🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause

MULTI-evolve: Rapid Evolution of Complex Multi-mutant Proteins | Arc Institute The search space for protein engineering grows exponentially with complexity. To address this problem, we developed MULTI-evolve, a framework for efficient protein evolution that applies machine learn...

Check out Arc’s related open roles: job-boards.greenhouse.io/arcinstitute...

Go behind the paper with the authors in this blog post: arcinstitute.org/news/multi-e...

Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.

Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.

Happy #ChineseNewYear!

Sending warmest wishes to JIC's Chinese communities, friends, followers and partners as we welcome the Year of the Horse 🐴

Big congratulations @kellythd-nguyen.bsky.social🥳👍👍👍

Big congratulations 🎉 👍👍👍

New paper out!

i-Motif, not G-quadruplex, stability regulates insulin expression - published in @narjournal.bsky.social

Team effort driven by Dr Dilek Guneri supported by Dr Chris Morris, @timcraggs.bsky.social, @yiliangding.bsky.social and Prof Steve Smith

academic.oup.com/nar/article/...

A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org

Loving this beautiful cover image in this week's @science.org illustrating the paper which came out online late last year
www.science.org/doi/10.1126/...

#Plantscience

Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform Mammalian SWI/SNF chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT (SW...

🧬 @science.org A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform | Science www.science.org/doi/10.1126/... @ckadoch.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social 🔬 #chromatin #transcription #cancer 🧫

The Ding lab wishes you a joyful Christmas and a New Year filled with happiness and discovery ❤️❤️❤️

CEPAMS Research Unravels Key Mechanism Governing Plant Stem Cell Activity - CEPAMS Left: the shoot apex of an Arabidopsis thaliana plant.Right: the shoot apical meristem. Actively dividing stem cells are shown in green, and the cell walls are labelled in magenta.

The work, recently published in the journal @science.org, was led by @weibingyang.bsky.social, with key contributions on RNA structure and localisation from @yiliangding.bsky.social: www.cepams.org/cepams-resea...

Chromatin buffers torsional stress during transcription During eukaryotic transcription, Pol II must overcome nucleosome obstacles and, because of DNA’s helical structure, must also rotate relative to DNA, generating torsional stress. However, there is lim...

@science.org Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...

Exciting project!Great opportunity!

New opportunity to join our #EvoMPMI group @johninnescentre.bsky.social as a Postdoctoral Researcher working on the mechanistic basis of immunity in diverse plants. Please spread the word, reach out by email, and/or apply if interested! More details here: www.jic.ac.uk/vacancies/po...

@incarnatolab.bsky.social delivered an outstanding talk on RNA structural ensembles in living cells — a truly groundbreaking perspective that could reshape how we approach RNA-based drug discovery. @norwichrnaclub.bsky.social

We are pleased to host Prof Ying Wang on Wednesday 3rd December 2pm @johninnescentre.bsky.social . Please join us for this exciting talk. @yiliangding.bsky.social @whaerty.bsky.social @alperakay.bsky.social @earlhaminst.bsky.social @biouea.bsky.social @rnasociety.bsky.social Lexogen

We are pleased to host Prof Danny Incarnato @incarnatolab.bsky.social on 5th December 9:30am @johninnescentre.bsky.social. Please join us for. @yiliangding.bsky.social @whaerty.bsky.social @alperakay.bsky.social @earlhaminst.bsky.social @biouea.bsky.social @rnasociety.bsky.social Lexogen

Super interesting talk by Ying Wang on plant viroid! What a nice model for studying RNA structure😊

Very excited to advertise 15 plant engineering biology PhD projects @biologyatyork.bsky.social @camplantsci.bsky.social @slcuplants.bsky.social @johninnescentre.bsky.social & University of Bristol. 🪴 🥬 🔧 🧬 Come join this new Plant BioDesign community!

www.findaphd.com/phds/?Keywor...

AI RNA Design for Developing Antiviral Solutions in Sugar Beet (Plant BioDesign JIC project) at University of York on FindAPhD.com PhD Project - AI RNA Design for Developing Antiviral Solutions in Sugar Beet (Plant BioDesign JIC project) at University of York, listed on FindAPhD.com

New PhD opportunity available in my lab, in collaboration with Betty Chung (Cambridge), focusing on plant RNA viruses and AI-driven design. www.findaphd.com/phds/project...

Rather than a static database, we've built an AI plant scientist that could continuously learn new knowledge😃Hope it will help the plant science community!@haopengyu.bsky.social @johninnescentre.bsky.social @thesainsburylab.bsky.social @universityofexeter.bsky.social #AIscientist

De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome - Nature Communications Available wheat genomes are annotated by projecting Chinese Spring gene models across the new assemblies. Here, the authors generate de novo gene annotations for the 9 wheat genomes, identify core and dispensable transcriptome, and reveal conservation and divergence of gene expression balance across homoeologous subgenomes.

Our pan-gtranscriptome analysis delivers a detailed roadmap for gene expression and regulation promising to fuel innovations in crop improvement to face climate challenges.
www.nature.com/articles/s41...
@earlhaminst.bsky.social @helmholtzmunich.bsky.social @edithcowanuni.bsky.social

De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome - Nature Communications Available wheat genomes are annotated by projecting Chinese Spring gene models across the new assemblies. Here, the authors generate de novo gene annotations for the 9 wheat genomes, identify core…

Exciting news in wheat science!
A new study in @natcomms.nature.com shows the first wheat pan-transcriptome: uncovering hidden diversity across modern wheat lines 🌾
Congrats to @earlhaminst.bsky.social & @helmholtzmunich.bsky.social for this major advance!
➡️ buff.ly/XEQlCnT
#WheatConnect

Congratulations! Very cool!