Krishanu Saha

Read the full paper via Open Access here: t.co/p2aGW5E93x

Thrilled to highlight the brilliant work by Mandana Arbab, Zaneta Matuszek, with the Mouro Pinto and Liu labs — another major leap forward for somatic cell gene editing. 👏🧬
Base editing as a therapeutic strategy for repeat expansion diseases
@NatureGenet
nature.com/articles/s41...

At a major genome editing summit, spotlight turns to the value of human life Earlier gatherings focused on gaining public acceptance for what scientists want to do with CRISPR. This meeting flipped that on its head.

At a major genome editing summit, spotlight turns to the value of human life www.statnews.com/2025/05/27/g... via @statnews.com

@laurensarko.bsky.social gave a great talk at #ASGCT2025:
CRISPR-engineered CAR T cells targeting senescence-associated uPAR

Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed.

#CRISPR #CellTherapy
@warfnews.bsky.social

Looking forward to this timely Scientific Symposium and conversation on #CRISPR #GeneEditing at #ASGCT2025!
“Who’s Afraid of Off-Target Editing?”
1:30–3:15 PM CT (Room 293–296)
With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of
@somaticediting Join us! #GenomicMedicine

Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells Saha and colleagues report an improved method to genetically engineer human primary natural killer (NK) cells using a virus-free CRISPR strategy, yielding high editing outcomes with minimal off-target...

Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific NK cells @sahakris.bsky.social
www.cell.com/molecular-th...

Proud to have you represent!

Congrats to Giulia Scimonelli from the @sahakris.bsky.social Lab. The research award, funded by grants from Brittingham Wisconsin Trust, Knapp Bequest, and UW Division for Teaching and Learning, allows her to study T Cell Phenotype Enrichment Through mRNA Delivery for Enhanced CAR-T Manufacturing.

🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate.
#CRISPR

ghi.wisc.edu/science-is-g...

🎉 Huge congrats to our newest PhD, Dr. Khajanchi (@omgitsnamita), on her stellar defense! 🌟 She delivered an outstanding presentation on her groundbreaking work developing a tunable #CRISPR genome editing system in human cells. Stay tuned for the preprint! 📄👏

🎓 Today at 10 am CT, join us at the DeLuca Forum or online for @omgitsnamita’s PhD defense on “Regulating Cas9 Genome Editor with Small Molecule Drugs.” 🌟

📍 @DiscoveryBldg
🔗 DM for Zoom link!
#CRISPR

Please join me in congratulating @Shankar_K2, Ph.D. on her thesis defense! 🎓 By integrating #CRISPR genome editing w/ cell engineering, Dr. Shankar has crafted programmable cell therapies that are foundational to our lab’s new directions. @CMaT_ERC @UWCarbone @UWMadison_BME

Two PhD defenses this week: Join us! Orchard View, 3280, @WIDiscovery:

@dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells

@Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.

At #ASGCT2024, we're showcasing advances in non-viral gene editing, CAR T cell therapies, & high-throughput screening. Explore our work on vision restoration, cancer therapy, and ethical challenges in the field. Join us to learn about the latest progress in #GeneTherapy research

Join us this Thursday, Mar 21!
A Question of Beginnings: Lab Embryos Between Nature and Synthesis
with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more.

@GenomeObserv

Registration:

More momentum for CRISPR drugs! This time, it’s through direct injection of nanoparticles into the body.

Learn about the first approved #CRISPR drug and our own efforts to build on this breakthrough...tomorrow morning @WPR at 7:30am Central. Call in with your questions: 800-642-1234 @WIDiscovery @uwsmph @UWMadEngr @somaticediting @CMaT_ERC

The first authorized medicine for the #CRISPR field! The US FDA decision is likely to come next month. We are all hoping that post-market/approval data is shared and the durability of efficacy is at least many years, as seen in the clinical trials. ⁦

Finding resonance with many others thinking about global governance of emerging tech here at the #ParisPeaceForum2023. Come see our roundtable discussion on #CRISPR genome editing tomorrow.

It’s been a joy to develop & teach this hands-on #CRISPR lab course for @UWMadEngr. Read about our journey here. Our teaching assistants - Jamie, Anna, and @smerchette - provided invaluable input, and the students are quickly becoming expert gene editors!

Here is an excellent and ongoing discussion of a #CRISPR gene-edited cell therapy on the brink of approval. An important guidepost for our in vivo somatic editing efforts @somaticediting

Congratulations to all the 2023 JITC Best Paper Award Recipients! Especially to former Ph.D. students in our @UWMadison lab: @kpmueller1 + @NicoleJPiscopo (w/@CapitiniMD @UWCarbone @CMaT_ERC) for Best Immune Cell Therapies & Immune Cell Engineering Paper

We are hiring! Join the UW-Madison Biomedical Engineering department as a faculty member in a vibrant research community. 👇

The ecosystem for biotech here in Madison and Wisconsin is on the rise… @UWCarbone @UWMadison @Forward_BIO

Our new @somaticediting article describing an unexpected distribution of #CRISPR genome editing in the brain. These new delivery vectors can travel in surprising ways within tissues after injection. With Emborg, Levine, @GongShaoqin @uwsmph @UWMadEngr

Happy to participate as an expert for this excellent @USGAO report on the applications, challenges, and policy options for regenerative medicine. Lots of exciting work ahead... #CellTherapy #GeneTherapy #CRISPR @NASEM_Health @CMaT_ERC @somaticediting

We are lucky to have @danielevanbauer visit us on Monday! Join us at noon for his seminar on #CRISPR gene editing of blood stem cells. @UW_CHGPM @uwsmph @UWMadEngr @UWCarbone @UWMadScience @UWSCRMC @UWMadison_CGSI @WIDiscovery

🔬🧬 Join our groundbreaking journey as we pave the way for in vivo #CRISPR treatments in the clinic! 🌟 Madison, an incredible place to live and a flourishing tech hub, awaits your talent and expertise. 🌇 (thread 1/6 for two positions)

2023 Camp Champions: Jishnu Saha | Camp Casco

⁦Thank you @NPR⁩ ⁦@robsteinnews⁩ for covering this important #HGEsummit and highlighting contributions from ⁦our growing @GenomeObserv⁩ efforts. ⁦@UWMadison⁩ ⁦@ASU⁩ ⁦@HarvardSTS⁩ #CRISPR