What a great evening! And impressive line-up of #RNA scientists. #Science #Munich
11.12.2025 19:00
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What a great evening! And impressive line-up of #RNA scientists. #Science #Munich
Very excited to attend the award symposium of the 2025 Heinrich Wieland prize, where the award will be presented to Prof. Adrian R. Krainer for his work on RNA splicing and clinical breakthrough using ASO's (anti-sense oligos). #RNA #medsky #munich #munichresidence @boehringerglobal.bsky.social
Happy to have contributed to this cool story, check it out now in @natureportfolio.nature.com
rdcu.be/enJ8P
With the GPATCH1-DHX35 and TFIP11-DHX15 pairs present, our work opens intriguing questions regarding splicing fidelity. Special thanks to Reinhard LΓΌhrmann for guiding us ribosome folks!
Known to regulate splicing of pre-mRNAs with non-canonical splice sites, we provide fiery structural details into the action of GPATCH1-DHX35. Soni et al. reported similar insights from S. Pombe, suggesting a conserved route to mitigate a common source of error during splicing. rdcu.be/ebDtT
We identify catalytically active spliceosomes that were intercepted by quality control: they contain a suboptimal pre-mRNA that is recognized by the G-patch protein GPATCH1, which binds its cognate RNA helicase DHX35, while disassembly factors DHX15-TFIP11-GCFC2 bind nearby.
Splicing in C.t. is surprisingly similar to humans (expanding @hitenmadhani.bsky.social work to thermophiles): CryoEM structures of ππ‘spliceosomes with a core resolution of 2.2A (one of the best in the fieldπ₯) are similar to recently published ones by the Plaschka and Cochella Labs rdcu.be/ebDt7
Hot and splicy π₯ Check out spliceosome complexes under quality control by GPATCH1-DHX35! We establish C. Thermophilum as serious player when it comes to spliceosomes. Great collaboration between the Hurt, Jingdong Cheng, Fei Xavier Chen and LΓΌhrmann labs. rdcu.be/ebBAx #spliceosome #somelikeithot