Johannes W. Dietrich

SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 (left) and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7 (right)

30 years of #SimThyr in #Marchintosh 2026: #SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7.

Thanks to the fact that the code was based on the #Pascal programming language, the software is highly portable, but runs with full native speed.

This explains the election results of the previous years...

The common denominator is narcissism and machiavellism. The other themes are a means to this end.

Carbon Dioxide Overload: Why Human Blood is Becoming More Acidic This blog post and the “Deep Dive” podcast, created by NotebookLM, are based on “Carbon dioxide overload, detected in human blood, suggests a potentially toxic atmosphere within 50 years” by Larcom…

A new article shows why rising atmospheric CO2 is acidifying our blood and weakening our skeleton - the human (and animal) biological equivalent of "ocean acidification". 🌊🧪 ocean2climate.org/2026/03/01/c...

🧪 🩺 #MedSky @medsky.social

Screenshot of Lazarus 4.6.0 on macOS 13.7.6.

The #Lazarus_IDE for #Free_Pascal has been updated to version 4.6, fixing bugs and updating localisations.

#Pascal #programming

www.lazarus-ide.org

🧪 🩺 #MedSky @medsky.social Endocrinology #Endosky

"Thinking is difficult, that's why most people judge."
#MedSky

Congratulations on this important work!

“We are the only species on the planet, so far as we know, to have invented a communal memory stored neither in our genes nor in our brains. The warehouse of this memory is called the library.”

— Carl Sagan

The image is AI-generated, while the real ship is in dry dock.

Aus der Veröffentlichung über Parteispenden des Deutschen Bundestags für das Jahr 2026: 50.000 Euro an die CDU von Dr. Arend Oetker, Bismarckallee 22, 14193 Berlin am 23.01.2026.

Das ist nur folgerichtig, wenn man erst vor vier Wochen eine nicht zu knausrige Spende von Dr. Oetker bekommen hat.

#Parteispenden #Korruption #Diabetes #Adipositas

Space Data Centers Are Dumb. YouTube video by Kyle Hill

Gran vídeo sobre datacenters, IA y estupidez humana, en general. (Por favor, ver hasta el final del todo)

www.youtube.com/watch?v=-w6G...

« Un déclin sans précédent » : la population des oiseaux des champs est en chute libre, alerte la LPO Les populations d’oiseaux des milieux agricoles en France ont chuté de 32,5 % depuis 2001, victimes de l’intensification des pratiques agricoles destructrices de leur environnement ou de leurs sources...

De moins en moins de haies et de zones humides, de plus en plus de pesticides. Résultats ? 20 millions d’oiseaux disparaissent chaque année en Europe
www.ouest-france.fr/environnemen...

L'homme préhistorique a longtemps été un mâle, héritier de l'imagerie masculine des premiers préhistoriens du XIXème siècle. La femme ? Masquée, oubliée au fond de la grotte ! Il était temps que le sujet soit pris en main, qui plus est par des femmes de sciences !

Man muss ja fürchten, dass dann manche im Entzugsdelir landen...

New calculation offers simple and reliable early prediction of diabetes Diabetes often remains undetected until it has already damaged organs or nerves. This is partly due to the fact that diagnosis at an early stage is time-consuming and difficult.

Diagnosis of #diabetes mellitus and #prediabetes: A simple calculation may be better than a complex test.

🧪 🩺 #MedSky @medsky.social #Endosky #Endocrinology

medicalxpress.com/news/2024-01...

Pairing Weight Training With GLP-1 Therapy for Optimal Weight Management By reinforcing exercise, health care providers can ensure that GLP-1 therapy leads to weight loss, sustains muscle mass, and improves health.

GLP-1 therapy should be combined with structured physical activity with resistance training to allow patients to maintain lean body mass, enhance their metabolic health, and prevent their loss of functional independence.

Read More: https://bit.ly/46tanEq

Gladys Mae West obituary: mathematician who pioneered GPS technology She made key contributions to US cold-war science despite facing huge barriers as a Black woman.

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.

Which just makes me want to share it again: www.nature.com/articles/d41...

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🧪 🩺 #MedSky @medsky.social

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🧪 🩺 #MedSky @medsky.social

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🧪 🩺 #MedSky @medsky.social

🧪 🩺 #MedSky @medsky.social

Prototyp der Cupola, ausgestellt im LWL-Museum für Industriekultur, Henrichshütte, Hattingen | Prototype of the Cupola module exhibited in the LWL-Museum für Industriekultur, Henrichshütte, Hattingen Own photo, now available from https://commons.wikimedia.org/wiki/File:Cupola-Prototyp_in_Hattingen.jpg

#Cupola​'s basic structure was built at the #Henrichshütte area in #Hattingen. It can be visited in the #LWL-Museum für #Industriekultur.

maps.apple.com?address=Werk...

Figure from the paper showing the experimental paradigm. Shortly, participants were asked to memorize the orientation of coloured bars before being presented with an arithmetic task.

Figure from the paper: Time–frequency plots per interruption condition averaged across midfrontal EEG channels.

Plot from the paper: Significant clusters showing the main effects of interruption averaged across duration conditions with the topographies marking the distribution of two significant clusters over the scalp. The vertical dashed lines indicate the onsets of the retro-cue (0 ms) and the memory probe (1,000 ms).

In working life, interruptions are widespread and can impair task performance. In an #EEG experiment that was controlled by software written in #Lazarus and #Free_Pascal, researchers found that temporal flexibility can benefit subgroups of workers.

#Pascal #programming

dx.doi.org/10.1037/pag0...

DCPcrypt v2.0.5 — Cryptographic library for Free Pascal/Lazarus

◆ 20 ciphers (AES, Blowfish, Twofish, DES, RC4...)
◆ 10 hashes (SHA-256, SHA-512, MD5, Tiger...)
◆ 6 block modes, stream encryption, Base64
◆ Pure Pascal, no dependencies
◆ 282 tests, full docs

github.com/NDXDeveloper/dcpcrypt-lazarus

Figura 1. Efectos de la triyodotironina (T3) sobre las funciones fisiológicas. Abreviaturas: HDL, lipoproteína de alta densidad; SR-B1, receptor scavenger, clase B tipo 1; T4, tiroxina; TSH, hormona estimulante del tiroides.

Figura 2. Mecanismos propuestos responsables del perfil característico de la hormona tiroidea (HT) en pacientes con deficiencia del transportador de monocarboxilatos 8 (MCT8). En el cerebro, el MCT8 se expresa en los tanicitos humanos, las neuronas que expresan la hormona liberadora de tirotropina (TRH) y las células foliculosteladas de la hipófisis, y es probable que sea un regulador clave de la homeostasis de la TH en el eje hipotálamo-hipófisis-tiroides. La pérdida de la función del MCT8 da lugar a niveles elevados de triyodotironina (T3) circulante que suprimen la secreción de TRH por el hipotálamo y la secreción de hormona estimulante del tiroides (TSH) por la hipófisis. Esto va acompañado de una reducción de la secreción de tiroxina (T4) por la tiroides, debido tanto a la disminución de la secreción de TSH por la hipófisis, el efecto directo de la deficiencia de MCT8 en las membranas de los tirocitos, que dificulta la salida de TH, como al aumento de la conversión periférica de T4 en T3. Esto conduce a un aumento de la T4 y la T3 intratiroideas y a la perturbación del mecanismo de retroalimentación. En los riñones, el aumento de la actividad de la enzima yodotironina desyodasa tipo I (DIO1), responsable de la conversión de T4 en T3, va acompañado de una disminución de la excreción y del «atrapamiento» de T4. Se cree que esto da lugar a una rápida conversión de la T4 atrapada en T3 y a la liberación de T3 en la circulación por transportadores alternativos.

La deficiencia de #MCT8, o síndrome de #Allan-Herndon-Dudley, es un trastorno grave y raro del transporte de la hormona #tiroidea. En nuestro último artículo, revisamos los avances más recientes en fisiopatología, diagnóstico y tratamiento.

pubmed.ncbi.nlm.nih.gov/41508830/
doi.org/10.1210/clin...