The Raman Room

Periodic and Statistically Distributed Surface Texturing of Surface‐Enhanced Raman Spectroscopy (SERS) Sensors with Spatially Selective Signal Mapping Molecular fingerprinting for the detection of biomolecules is highly sensitive and noninvasive through the surface-enhanced Raman scattering (SERS) effect. This is a report on the commercially compet....

Yay! Out now in the final version!
Periodic and Statistically Distributed Surface Texturing of Surface‐Enhanced Raman Spectroscopy (SERS) Sensors with Spatially Selective Signal Mapping, Daskalova et al., Advanced Physics Research, 5(3), e00124, 2026
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Green synthesis of Ag@Cu and silver nanowire using Pterospermum heterophyllum extracts for surface-enhanced Raman scattering

This study reports #greensynthesis of Ag@Cu #nanoparticles & #AgNWs using Pterospermum heterophyllum extract, achieving optimal morphology & strong #SERS enhancement, showing #ecofriendly methods rival chemical routes for sensing.

Green Processing and Synthesis: doi.org/10.1515/gps-...

Abstract: A small remote Raman sensor was used to measure the Raman scattering signal from clear, still water as a function of water depth (12 cm and 396 cm depth), sensor distance above the water surface (20–300 cm), and angle of incidence (0–80°) to the normal of the water surface. Under thick- and thin-sample conditions, the signal depends on either the inverse, or the inverse square, of sensor distance from the water surface, respectively. A model is derived that fits data for different sensor distances, water depths, and angles of incidence. Fits to the measured data are consistent with the known intensity of water Raman scattering and the specifications of the detection system. This manuscript provides a mathematical model that can be used to predict and evaluate the performance of remote sensors and can be expanded to account for differing experimental conditions.

New from Applied Spectroscopy!
Pathlength, Altitude and Angle of Incidence Dependence of Remote Water Raman Scattering
Read more: https://doi.org/10.1177/00037028251394346
#SAS #Spectroscopy #Remote #water #Raman #Scattering

Can Raman spectroscopy unlock continuous vaccine manufacturing? Researchers at Purdue and Merck developed a real-time, at-line Raman tool to monitor viral particles in flow, reducing QC delays and improving process control.

Read more: https://ow.ly/CyIl50Y83te
#VaccineManufacturing #Bioprocessing

Moving forward, we have Iva Mihova presenting her research: 'Tracing Compositional Groups of Late Roman Glass from two caves at Punta de les Coves applying XRF and Raman Spectroscopy'. #6thVCWAP

She has a MSc in Archaeology from the University of Barcelona and currently works in commercial archaeology. Her research focuses on analytical techniques applied to archaeological materials, in this case Roman glass artefacts examined with XRF and Raman Spectroscopy.

This study highlights the difference in production technologies and recycling practices across two periods of the Roman Empire in the same spatial setting.

Moving forward, we have Iva Mihova presenting her research: 'Tracing Compositional Groups of Late Roman Glass from two caves at Punta de les Coves applying XRF and Raman Spectroscopy'. #6thVCWAP

A photo of the portable Raman analyzer, which can remotely measure very low concentrations of hydrogen gas in ambient air, even in outdoor environments.

A representation of the analyzer's mechanism, in which blue pump light and Raman scattered light from hydrogen reflect a great number of times in a multipass cavity to dramatically improve detection sensitivity.

Portable Raman analyzer detects hydrogen leaks from a distance: https://bit.ly/4iA63GF

A robust enhancement mechanism reflects which blue pump light and Raman scattered light from hydrogen in a multipass cavity to dramatically improve detection sensitivity.

#NationalScienceDay 💡 ⚛️

A striking 1928 milestone came when C. V. Raman identified the Raman effect, revealing how scattered light shifts in wavelength to expose the molecular structure of matter. This discovery reshaped spectroscopy and expanded how scientists study the physical world. #ScienceHistory

New: Speakers just announced for a #FaradayDiscussion on Surface‑Enhanced Raman Scattering (SERS), 14–16 April 2027, London, UK. Visit rsc.li/sers-fd2027 for details of how to join in. #ChemSky

Domain-Level Classification of Archaea and Bacteria Using AI-Assisted Single-Cell Raman Spectroscopy Archaea and Bacteria are two fundamentally distinct domains of life that share prokaryotic traits, yet differ markedly in molecular and cellular architecture. While many archaeal species identified thus far have been found in extreme environments, recent metagenomic studies have revealed their widespread presence in moderate habitats, including soils, oceans, and even the human microbiome. However, archaea remain less well characterized than bacteria, largely due to the technical challenges associated with culturing and identifying these microorganisms. In this study, we present a culture-independent method for discriminating archaea from bacteria at the single-cell level using Raman spectroscopy combined with machine learning. We constructed a Raman spectral data set comprising 22 prokaryotic species (11 archaea and 11 bacteria) and developed a domain-level Archaea–Bacteria (AB) classifier using the LightGBM tree-based machine learning algorithm. Our AB classification model achieved an average classification accuracy of 89.1% and a sensitivity of 98.1% on eight representative species (including two independent held-out test species) with minimal data size and preprocessing. We also compared its performance to convolutional neural networks with transfer learning, a widely used deep learning approach. Our method provides a robust analytical framework for archaeal detection and represents a valuable addition to the microbiological toolkit, particularly for studying unculturable or low-abundance archaeal populations in complex microbial communities.

Domain-Level Classification of Archaea and Bacteria Using AI-Assisted Single-Cell Raman Spectroscopy | ACS Omega https://pubs.acs.org/doi/10.1021/acsomega.6c00460

👁️Non-invasive method for molecular profiling of the human retina: #Raman #spectroscopy at the optic nerve head reveals age‑linked changes in the retina, establishing its potential as an early diagnostic tool for #ophthalmic and #neurodegenerative disease biomarkers.
www.nature.com/articles/s42...

Effects of petroleum-based and biodegradable bio-based microplastics versus natural control particles on Paramecium caudatum, combined with in situ Raman spectroscopic detection The impacts of microplastics (MPs) are becoming increasingly concerning. Although many ecotoxicological studies have examined potential effects of MPs…

📣 New CRC 1357 Article: Effects of petroleum-based & biodegradable bio-based microplastics vs natural control particles on Paramecium caudatum

🔬in situ µ-Raman spectroscopy
🦠Reproduction in P. caudatum increases

Read open access
👉 www.sciencedirect.com/science/arti...

Shining a light on the life of C.V. Raman As the nation celebrates the day with science exhibitions and fairs in schools and research institutions, let’s trace the journey of the man who sparked our scientific curiosity.

Shining a light on the life of C.V. Raman
www.thehindu.com/children/shi...
@thehindu.com

Three Raman techniques, all on the same device: https://bit.ly/4cAXU5x

Tandem Raman microscopy, which integrates SRS, CARS and [(R)RS], enables the comprehensive observation of Raman phenomena across diverse physical origins, including both linear and nonlinear effects. 💡 🧪 ⚛️ #NationalScienceDay

Today, 28 February, we celebrate #NationalScienceDay, which marks the discovery of the Raman effect by Sir C. V. Raman.

To celebrate, we compiled some of our favorite articles and images that were made possible by the Raman effect's discovery: https://bit.ly/4rIJnsT

#Research ⚛️ 🧪 💡

Laser technique can quickly check mRNA packaging in lipid nanoparticles Messenger RNA (mRNA) technology is transforming medicine by providing our cells with genetic instructions to produce proteins that help the immune system prevent or fight a wide range of diseases, including cancer and other rare disorders.

A laser-based Raman spectroscopy technique enables rapid, non-destructive assessment of mRNA encapsulation in lipid nanoparticles, supporting the quality and safety of mRNA therapeutics. doi.org/hbqrgh

🔔Inside cover of Issue 4 presents

Real-time vibrational fingerprinting of liquid-phase sulfide electrolyte synthesis 𝘷𝘪𝘢 𝘪𝘯 𝘴𝘪𝘵𝘶 Raman spectroscopy by Nataly Carolina Rosero-Navarro 𝘦𝘵 𝘢𝘭.

#SolidStateBatteries #InSituSpectroscopy #RamanSpectroscopy #Free_to_read
doi.org/10.1039/D5QI...

A black and white portrait of Sir C. V. Raman, with the text "Did You Know? The Raman Effect became the foundation of Raman spectroscopy, a technique still widely used today in chemistry, physics, medicine, and materials science, from identifying molecules to analyzing art and space samples."

#OnThisDay in 1928, physicist Sir C. V. Raman discovered what we now call the Raman Effect: showing that when light passes through a transparent material, some of it changes wavelength. This breakthrough transformed how we study matter at the molecular level. 🌈🔬

front cover of issue 8 of Analytical Methods: This cover weaves together two moments in time, with Charles Darwin studying preserved specimens, surrounded by countless jars. In the foreground, a hand-held Raman device scans a sealed jar, revealing the chemistry of its preservation fluids through the first non-invasive application of spatially offset Raman spectroscopy (SORS), offering a new way to assess and protect museum collections

On the front cover of issue 8 of Analytical Methods:
Characterizing noninvasively conservation status of historical wet collections using spatially offset Raman spectroscopy.
#OpenAccess from Wren Montgomery, Sara Mosca et al @arasfly3.bsky.social. Read now: pubs.rsc.org/en/content/a...

Portrait of Prof. Jürgen Popp

Prof. Juergen Popp, Scientific Director @leibnizipht.bsky.social and Professor of Physical Chemistry at #UniJena, has been awarded the 2026 Ellis R. Lippincott Award for his pioneering contributions to translational clinical Raman spectroscopy. Congratulations! 👏
➡️ www.uni-jena.de/391182/juerg...

Image depicting a plasmonically active Ag/Ni/NiO nanowire substrate enabling highly reproducible surface-enhanced Raman spectroscopy

Check out the front cover of issue 4 of Nanoscale Advances!
'High reliability Ag/Ni/NiO nanowire-based SERS for cancer detection: a study on breast cancer' by Alondra Hernandez Cedillo et al.
doi.org/10.1039/D5NA...

Phonon lasers unlock ultrabroadband acoustic frequency combs Acoustic frequency combs organize sound or mechanical vibrations into a series of evenly spaced frequencies, much like the teeth on a comb.

A new phonon-laser approach enables acoustic frequency combs with up to 6,000 teeth and tunable spacing from 10 Hz to 100 kHz, advancing capabilities for sensing and imaging applications.

Extract: We are seeking a highly motivated postdoc to develop and apply advanced data analysis methodologies for low-frequency Raman and Brillouin spectroscopy of pharmaceutical materials, focusing on chemometric and machine learning frameworks.

University of Copenhagen is hiring:
Postdoctoral Researcher in Low-Frequency Vibrational Spectroscopy and Machine Learning for Pharmaceutical Materials

#postdocposition

Colorful graphic with a quote from Rekha Gautam at the top, with a photograph of Gautam below smiling in a professional headshot.

It’s #WiOWednesday!

We’re celebrating Rekha Gautam, Senior Scientist and Raman Team Lead at @tyndallinstitute.bsky.social. Her research in Raman spectroscopy & biological screening continues to advance #optics and #photonics. 💡

Read her 2026 SPIE Women in Optics profile: https://bit.ly/4trhqYp

🎓 Congratulations to Věra Schrenková (Petr Bouř group) who successfully defended her PhD thesis entitled "Polarized Raman spectroscopy for studying molecular structure" at @vschtpraha.bsky.social/UCT Prague!

#phd #phdatIOCB #phdjourney

Image in pink/purple tones showing wavy lines at the bottom and spectroscopic tip (red) pointing onto a blue/green 2D material (graphene) for exfoliation.

Take a look at this inside front cover of Issue 3, out now!

"Raman spectroscopy of electrochemically exfoliated graphene: defect evolution, doping effects, and interpretive frameworks" from M. J. Madito

🔗 pubs.rsc.org/en/cont...

Label-Free Differentiation of Antimicrobial Resistance Groups Using Raman Spectroscopy
https://doi.org/10.1021/acs.analchem.5c03370

Ultra‑clean twisted MoS₂ bilayers made by simple direct bonding, revealing twist‑angle‑dependent Raman features and device performance. A big step for moiré 2D materials 👉 https://ow.ly/h7e750Y9QeX

As a spectroscopist, your database is your ultimate legacy - so make sure to check out George's mineral [Raman + FT-IR] spectroscopy server! [3/3]

Link: minerals.gps.caltech.edu

I am heartbroken to learn to George Rossman has passed away - George was not only a brilliant chemist turned geoscientist, but also had an exceptionally good taste in methods - Raman + FT-IR spectroscopy - and cookies ... [1/3]

www.gia.edu/gia-news-pre...