Swiss Myeloid League (SMyLe)

Resident tissue macrophages maintain intraocular pressure homeostasis Intraocular pressure (IOP) is dysregulated in glaucoma, a leading cause of blindness. Immune contributions to IOP maintenance are poorly understood. Liu et al. reveal that long-lived resident tissue macrophages have a specialized role in IOP homeostasis by regulating extracellular matrix turnover. These findings identify an integral homeostatic role for tissue-resident macrophages in resistance-generating tissues that are dysfunctional in glaucoma.

Online now: Resident tissue macrophages maintain intraocular pressure homeostasis

Honoured to serve as President of the Swiss Young Immunologists Society (SYIS).

We aim to connect early-career immunologists across Switzerland, strengthen our community, and support professional growth.
Looking forward to what we will achieve together!

To join the team syis-ecr.org/join-our-team/

Macrophage-rich niches regulate T cell dynamics at the liver invasive margin during gallbladder cancer progression @jci.org
www.jci.org/articles/vie...

Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes @jem.org @stijnverwaerde.bsky.social @ki.se @viblifesciences.bsky.social
rupress.org/jem/article/...

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment
rupress.org/jem/article-... @jem.org @umasschan.bsky.social

EHF promotes the maturation and immunosuppression of conventional dendritic cells @natcomms.nature.com
www.nature.com/articles/s41...

Myeloid core of TB granulomas is partitioned into two distinct metabolic environments, one of which is hypoxic & associated with pathological immune cell states that subvert immunity to TB @natimmunol.nature.com @erin-mccaffrey.bsky.social
www.nature.com/articles/s41...

Identification of endometrial CD169+ macrophages essential for Treg cell accumulation and implantation @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Homeostatic maturation programs drive human cDC2s into a tolerogenic state @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells in vivo.

Another paper out this week in @scienceimmuno.bsky.social by the Reizis laboratory showing that "Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells" Congrats 👏https://www.science.org/doi/10.1126/sciimmunol.adx4622

Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1

The very first @smyle-ch.bsky.social (SMyLe) seminar is happening tomorrow at 16:30 with @matekiss.bsky.social (Dr. Máté Kiss)!

Looking forward to welcoming lots of myeloid enthusiasts to our first event.

Transcription factor Etv3 controls the tolerogenic function of dendritic cells Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...

Very happy to share the final chapter of my postdoc work with Boris Reizis @NYU @uchicagocoi.bsky.social published today in @science.org! We identify and define the role of transcription factor ETV3 in the tolerogenic function of dendritic cells (DCs). 1/

www.science.org/doi/10.1126/...

A macrophage-induced subpopulation of mesenchymal cells expressing Fcer1g contributes to wound-induced fibrosis @natcomms.nature.com
www.nature.com/articles/s41...

OBS Neuroimmunology Webinar SPEAKER HIGHLIGHT

🔬 Speaker: Moriah Hovde, Laboratory of Dr. Rudy Tanzi, MGH

🧠 Talk: Inhibition of ACAT 1 promotes shedding of soluble TREM2 and LRP1-dependent phagocytosis of amyloid beta protein in microglia

💻 Register on Zoom: us02web.zoom.us/meeting/regi...

Spatial immune hubs defined by conserved activated dendritic cells are remodeled by immunotherapy https://www.biorxiv.org/content/10.64898/2026.02.10.703136v1

#internationaldayofwomenandgirlsinscience #eacr #womeninscience | Johanna Joyce Today is the #InternationalDayofWomenandGirlsinScience - a moment to recognise and celebrate women across all of the #EACR community 🙌 From Board members working together across Europe, to the dedic...

Today is the #InternationalDayofWomenandGirlsinScience - celebrating women across our @helloeacr.bsky.social community 🙌

From Board members across Europe to the #EACR HQ team and the scientists we serve worldwide, women play a central role in advancing cancer research every day

#WomeninScience 👩🏻‍🔬🧪

Gut macrophages and Parkinson’s disease Nature Reviews Immunology, Published online: 11 February 2026; doi:10.1038/s41577-026-01281-7Intestinal macrophages that support the enteric nervous system may be involved in the spread of α-synuclein pathology from the gut to the brain.

Gut macrophages and Parkinson’s disease

Preprint: TREM2⁺ myeloid cells limit perioperative CAR T-cell efficacy, highlighting need for neoadjuvant strategies to overcome post-resection immunosuppression in GBM @biology-unige.bsky.social
www.researchsquare.com/article/rs-8...

Matrix-bound nanovesicles elicit epigenetic changes in myeloid cells, modulating their response to future inflammatory events
www.science.org/doi/10.1126/...

Happy to announce our very first SMyLe seminar. Please join us for this exciting talk entitled "Transcriptional regulation of neutrophil plasticity in cancer" by Dr. Máté Kiss @matekiss.bsky.social on February 17th at 16.30 at ETH Höngg (HCI J6) or via Zoom (ethz.zoom.us/j/63706799264).

Hidalgo Lab | Mapping Innate Immunity Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.

I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com

Thank you to Gerardo Barcia for his beautiful design and constant support in building it

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart Respiratory infection and cardiovascular disease risk are tightly intertwined clinically, but the mechanisms of this relationship are largely unknown. Here, Downey et al. reveal how influenza traffics to the heart from the lung largely within pro-DC3s, which unleashes a damaging type I interferon program that compromises cardiac function.

Online now: Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart

Registration is now open and an all-in roster of immunologists anchor the premiere Dendritic cell meeting. www.dc2026sandiego.com/invited-spea... Sunny (blue state) San Diego. Sessions devoted to honoring 15 year anniversary of Nobel prize (Steinman) and translational advances…what is not to like.?

Meningeal blood vessel blockage enhances anti-tumor immunity against GBM in preclinical models by expanding dural resident border-associated macrophages that are poised for effective T cell activation @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understanding the accompanying mechanisms could pave the way for early-stage biomarkers.

Nature research paper: Intestinal macrophages modulate synucleinopathy along the gut–brain axis

go.nature.com/4rg6DOI

New webinar coming TOMORROW ‼️
David Menassa from University of Oxford and Karolinska Institute will be our next speaker on February 3rd. Check all the information in the flyer and add it to your calendar! @ki.se @ox.ac.uk 🧠🧬

Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors The function of the Alzheimer’s disease (AD) risk gene INPP5D in microglia remains unclear. Xie et al. identify INPP5D as a direct regulator of RIPK1 kinase, known to be implicated in mediating neuroinflammation. They show that INPP5D deficiency in aging activates RIPK1-dependent diverse innate immune signaling, promoting TDP-43 pathology and neuronal loss associated with AD and motoneuron degeneration, such as amyotrophic lateral sclerosis (ALS).

Online now: Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors