Congratulations Matthias Merkenschlager, lead PI Daniel Panne @uniofleicester.bsky.social & Benjamin Rowland @nkinl.bsky.social on their Wellcome Discovery Award!
They'll work across scales from the atomic to the organismal to learn how cohesin organises genomic processes central to human disease.
We wrote a protocol article detailing induction of dormancy in stem cells, embryos, and blastoids. We hope that it is useful to the community. As usual fun to work with @nicolasrivron.bsky.social, Heidar and Dhanur.
Our latest story is now on bioRxiv. We present PETRA, a new method for deciphering how sequence variants impact gene regulation at scale.
www.biorxiv.org/content/10.1...
This work was led by Magdalena Armas Reyes, a @crick.ac.uk PhD student until very recently. Congrats, Dr. Armas!
🧵 1/9
We are also recruiting a Postdoc in cell/molecular biology!
3yr, fully funded by @cancerresearchuk.org more details here: news.cancerresearchuk.org/2025/11/27/s...
Apply here: www.imperial.ac.uk/jobs/search-...
We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
🧬 We’re #Hiring a #Bioinformatician/ Computational Biologist!
#Single-cell genomics, #Epigenomics & #3Dgenome biology in #Zebrafish #DevBio 🐟
📍 @cabd-upo-csic.bsky.social, CABD, Seville (Spain)
🕒 Full-time, 3-year position (start March 2026)
📅 Apply by Feb 15, 2026
👉 drive.google.com/file/d/1M8rp...
Our work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41...
Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)
Don't forget to register for our upcoming Spring Meeting: 'Molecules to Morphogenesis'
Get your abstracts submitted by the 16th of January!
bsdb.org/meetings
We are hiring!
Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute @ki.se.
If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out!
#hiring #sciencejob #STEMJobs
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Helping this mood is our latest now out in its final form! @irfankathiriya.bsky.social leading the teams with me. Thanks to the editors and reviewers (incl. @wythelab.bsky.social)for a pleasant and productive journey. More to come when the full issue is out. www.nature.com/articles/s44...
Ancient #viral #DNA shaped early #embryonic development ...
| #virus | #TransposableElements | #genome | #infection | By @mrc-lms.bsky.social via @sciencex.bsky.social
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
New lab preprint!
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Congratulations Jesse!!!
Congratulations again Michelle 👏 👏👏 So well deserved!!!
Congratulations, Fany!! Fantastic news!! So much deserved 👏 👏👏
Congratulations to LMS group head @mpercharde.bsky.social
who has been selected as one of this year’s EMBO Young Investigators! 🌟
The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields.
@embo.org
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT
Register now for the EMBO Workshop "Limb development and regeneration: Quantitative, ecological, and diversification studies" in #Tokyo, Japan, 23–27 March 2026.
Abstract submission/Registration deadline:
12/15 December 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #EMBOevents 🧪
📣 We’re hiring 6 new Team Science postdocs!
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
