Edward Pimentel

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm!

elifesciences.org/articles/88794

colab.research.google.com/github/Masaa...

Follow @inprep.bsky.social for the best #ScienceSatire anywhere!

Amazing work by my former labmate, Ashley and collaborators in the @chembiobryan.bsky.social group!

How Scientists Learn to Tell Their Research Story | CAS Future Leaders™ YouTube video by CAS, a division of the American Chemical Society

Did you know that narratives can generate interest in your research? @storycollider.bsky.social provides #CASFutureLeaders with skills for effective storytelling. If you're a Ph.D. student or postdoc, apply for the 2026 program by January 25. www.cas.org/about/future... youtu.be/3J9LvBqM8XY?...

Lighting a better path for biobased furans Photocatalytic hydrolysis offers a shortcut for renewable chemicals

Researchers have developed a light-driven catalytic method to hydrolyze furans, offering a more efficient way to exploit them in biorefineries. cen.acs.org/synthesis/gr... #chemsky 🧪

New reagents take the burn out of butyllithium Merck KGaA's non-pyrophoric butyllithium in poly(α-olefin) oil make BuLi stable to air and water

Dissolved in poly(alpha-olefin) oil, the reagents don’t ignite or smoke in air, making them easier to handle and less prone to degradation on storage, while maintaining performance across a range of reaction types.

Lucky manufacturing glitch of the week: finding 0.5 mL centrifuge tubes mixed in with the 1.5 mL tubes we ordered. It's like finding the plastic baby figurine in your slice of the king cake! @eppendorf.bsky.social #chemchat 🧪

Computational design of conformation-biasing mutations to alter protein functions Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

Amazing work from the @aliceyting.bsky.social lab! Especially cool to see the functional effect of the conformational biasing on enzyme activity. www.science.org/doi/10.1126/...

Cool new chemistry for covalent ligand development targeting arginine 👏

Very cool work in this preprint from the Krishnan lab!

Forbes 30 Under 30 2025: Science Inventing the future from the atom up

Amazing to see two of my Soh Lab teammates on the #ForbesUnder30 Science list today: Congratulations Yihang and Yahao! www.forbes.com/30-under-30/...

This is an amazing program. Check it out and apply!

Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox

For full text: authors.elsevier.com/a/1m43W9CpcY...

Our mini-review on DNA-scaffolded catalysis is out today in @cp-trendschem.bsky.social! It's an interesting look at this unique intersection of catalysis, DNA nanotechnology and supramolecular chemistry. Give it a read! #chemsky doi.org/10.1016/j.tr...

Just stumbled across Orca Sciences' technical articles. Interesting reads! www.orcasciences.com/reading-diff...

RNA structure prediction is hard. How much does that matter? 4.8k words, 22 minute reading time

Interesting article about RNA structure prediction - we're always wishing we had better structure prediction tools for aptamers, and this article sums up the challenges very neatly! www.owlposting.com/p/rna-struct...

Stereo-reversed E2 unlocks Z-selective C–H functionalization The stereoselective functionalization of C–H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C–H activation chemistry, methods for Z-selective functi...

In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins.

chemsky 🧪

www.science.org/doi/10.1126/...

An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...

Discovery of high-specificity DNA aptamers for progesterone using a high-throughput array platform Aptamer-based biosensors offer several advantages for detecting small molecules, including chemical stability and compatibility with diverse sensing formats. However, developing highly specific DNA ap...

New preprint from the Soh lab! Nice work by my labmate Haji - new highly specific steroid aptamers identified using our modified sequencer platform! These don't have the 3wj structure and promiscuity of previous aptamers - I've used it myself! #chemsky www.biorxiv.org/content/10.1...

#chemsky 🧪

Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)

Fascinating work by @philiplampkin.bsky.social from the Gellman lab about preorganization in bifunctional catalysts! Controls like the alkyl-tethered catalysts in this paper are important for assessing the role of the supramolecular scaffold, but rarely investigated. Give it a read!

Title: Data understanding A Venn diagram with 2 circles that aren't even touching. One is labelled "data we have" and the other "data we need"

A very apt Venn diagram (dunno original source)

I loved reading about the Dickinson lab's masked acylating reagent approach to proximity labeling in Nature Chemistry last year (www.nature.com/articles/s41...), and was really excited when @jeffmartell.bsky.social and my labmate Ashley got involved. Check the pre-print out!

ACS Graduate Student Success Grant - American Chemical Society To support graduate students (M.S. and Ph.D.), within one year of degree completion, whose education and training were disrupted due to recent termination or cancellation of research grants. Funding w...

Cool grant program by ACS that supports graduate students whose Masters/PhD is being impacted by canceled grants: www.acs.org/funding/gran...

a canva graphic that says "How it works Step 1: Go to SkypeAScientist.com Step 2: Click “Sign Up” then “Scientist Sign Up Form” Step 3: Tell us about yourself Step 4: Get matched with a classroom Step 5: Connect with the teacher Step 6: Make a kid’s day isn't that great? @SkypeAScientist"

Scientists!

@skypeascientist.bsky.social matches scientists with classrooms, libraries, & more for virtual Q&As! It's easy and fun!

We are looking for 750 more volunteers by 8/15

If you're down to chat with 1-5 classrooms this semester, sign up here
www.skypeascientist.com/sign-up.html

Really proud to have been a part of this!

‘Creative destruction’ in the chemistry lab Some obsolete lab equipment is quickly replaced, while other items are stubbornly persistent. What modern tech will survive to the 2060s?

A walk around your lab might reveal some true relics of the past. Derek Lowe asks which equipment will survive the test of time, and which may have to move over for something fancy and new – and makes some predictions of his own.